|Zonisamide Zonisamide

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Generic name: Zonisamide
Brand names: Zonegran

Why is Zonisamide prescribed?

Zonisamide helps reduce the frequency of partial epileptic seizures, a form of epilepsy in which neural disturbances are limited to a specific region of the brain and the victim remains conscious throughout the attack. The drug is used in combination with other antiseizure medications, not by itself.

Most important fact about Zonisamide

Do not stop taking Zonisamide on your own. If the doctor decides to discontinue Zonisamide, he will tell you how to taper off slowly. Abrupt discontinuation of Zonisamide can cause seizures.

How should you take Zonisamide?

Zonisamide capsules should be swallowed whole and can be taken with or without food.

--If you miss a dose...

Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

--Storage instructions...

Store at room temperature in a dry place. Protect from light.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zonisamide.

  • More common side effects may include:
    Abdominal pain, agitation, confusion, depression, diarrhea, difficulty concentrating, difficulty with memory, dizziness, double vision and other visual disturbances, drowsiness, fatigue, flu syndrome, headache, insomnia, irritability, loss of appetite, loss of muscle coordination, mental slowing, nausea, prickling or burning skin, rash, speech abnormalities, tiredness

Why should Zonisamide not be prescribed?

Do not take Zonisamide if you are allergic to sulfa drugs such as Bactrim.

Special warnings about Zonisamide

If you develop a rash while taking Zonisamide, call your physician immediately. It could be a sign of an allergic reaction.

Zonisamide may cause drowsiness. Do not drive a car or operate dangerous machinery until you know how the drug affects you.

People who take Zonisamide are prone to develop kidney stones. To reduce the risk of stone formation, be sure to drink plenty of fluids. Call your doctor immediately if you develop symptoms of kidney stones such as back pain, abdominal pain, painful urination, or blood in the urine.

Call your doctor if you start to bruise easily or develop a fever, a sore throat, or blisters in the mouth. These could be signs of anemia or other blood problems that Zonisamide has been known to trigger in very rare cases.

Contact your doctor immediately if you develop severe muscle pain or weakness.

Contact your doctor immediately if your seizures worsen.

Zonisamide may interfere with a child"s ability to perspire and control body temperature, leading to a medical emergency. Zonisamide is not approved for use in children under 16.

Possible food and drug interactions when taking Zonisamide

If Zonisamide is taken with certain other drugs, the effects if either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zonisamide with the following:

Carbamazepine (Tegretol)
Phenytoin (Dilantin)
Valproate (Depakote)

Special information if you are pregnant or breastfeeding

In most cases, Zonisamide should not be taken by pregnant women because there is a chance that it could harm the developing baby. If you are pregnant or plan to become pregnant, tell your doctor immediately.

It is not known whether Zonisamide appears in breast milk, but because it could cause a serious reaction if it did, you"ll probably need to make a choice between breastfeeding and continuing your Zonisamide therapy. Be sure to discuss the question with your doctor.

Recommended dosage


The recommended starting dose for adults over the age of 16 is 100 milligrams daily as your doctor directs.

Your physician may wish to increase the dose by 100 milligrams every 2 weeks to a maximum of 600 milligrams per day. Larger doses can be divided into two smaller doses taken twice a day.


Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

  • Symptoms of Zonisamide overdose may include:
    Diminished breathing, loss of consciousness, low blood pressure, slow heartbeat

Where can I get more information about Zonisamide Zonisamide ? We recommend to use www.Drugs.com

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