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Some commonly used brand names are:
In the U.S.—
Ondansetron (on-DAN-se-tron) is used to prevent the nausea and vomiting that may occur after therapy with anticancer medicines (chemotherapy) or radiation, or after surgery.
Ondansetron is available only with your doctor"s prescription, in the following dosage forms:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ondansetron, the following should be considered:
Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to ondansetron. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy—Ondansetron has not been studied in pregnant women. However, this medicine has not been shown to cause birth defects or other problems in animal studies. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.
Breast-feeding—It is not known whether ondansetron passes into the breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor.
Children—This medicine has been tested in a limited number of children with cancer 6 months of age or older and after surgery in children 1 month to 12 years of age. In effective doses, the medicine has not been shown to cause different side effects or problems than it does in adults.
Older adults—This medicine has been tested in a limited number of cancer patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults.
Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Other medical problems—The presence of other medical problems may affect the use of ondansetron. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
If you vomit within 30 minutes after taking this medicine, take the same amount of medicine again. If vomiting continues, check with your doctor.
For patients using the oral disintegrating tablet form of this medicine:
Dosing—The dose of ondansetron will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only average doses of ondansetron. If your dose is different, do not change it unless your doctor tells you to do so.
Missed dose—If you miss a dose of this medicine, and you do not feel nauseated, skip the missed dose and go back to your regular dosing schedule. If you miss a dose of this medicine, and you feel nauseated or you vomit, take the missed dose as soon as possible.
Storage—To store this medicine:
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Chest pain or discomfort; pain, redness, or burning at place of injection; shortness of breath; skin rash, hives, redness, and/or itching; tightness in chest; troubled breathing; wheezing
Incidence not known
Blurred vision; cold, clammy skin; confusion; coughing; decreased or irregular heartbeat; difficulty in breathing or swallowing; dizziness or fainting; dizziness, faintness, or lightheadedness when getting up from a lying position; fast, pounding, slow, or irregular heartbeat or pulse; fast, weak pulse; fixed position of eye; heart stops; hives or welts; hoarseness; inability to move eyes; increased blinking or spasms of eyelid; lab results that show problems with liver; large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs; lightheadedness; no breathing; no pulse or blood pressure; noisy breathing; pain in neck, back, or jaw; palpitations; shortness of breath; slow or irregular breathing; sticking out of tongue; sweating; swelling of face, throat, or tongue; trouble in breathing, speaking, or swallowing; unconscious; uncontrolled twisting movements of neck, trunk, arms, or legs; unusual facial expressions; weakness; weakness of arms and legs
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Constipation; diarrhea; fever; headache
Abdominal pain or stomach cramps; burning, tingling, or prickling sensations; dizziness or lightheadedness; drowsiness; dryness of mouth; feeling cold; itching; unusual tiredness or weakness
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
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