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Generic Name: Drospirenone/Ethinyl Estradiol Tablets (droe-SPYE-reh-nohn/ETH-ah-nahl ESS-trah-DIE-ole)
Brand Name: Yasmin

Cigarette smoking increases the risk of serious heart problems associated with use of Yasmin . This risk increases with age and with heavy smoking (15 or more cigarettes per day) and is increased in women older than 35 years of age. Women who use Yasmin should not smoke.

Yasmin is used for:

Preventing pregnancy.

Yasmin is an estrogen/progestin combination. It works by preventing the release of eggs from the ovaries, thereby preventing pregnancy.

Do NOT use Yasmin if:

  • you are allergic to any ingredient in this medicine
  • you have blood disorders (eg, porphyria); blood clots in the legs, eyes, or lungs; or a history of developing blood clots in your legs
  • you are pregnant or think you may be pregnant
  • you have heart disease, including a history of heart attack; severe high blood pressure; kidney or liver disease; a liver tumor; adrenal disease; or a history of stroke
  • you have breast cancer or possible cancer of the uterus, cervix, or vagina; abnormal vaginal bleeding; or endometriosis
  • you are taking nevirapine, rifampin, or St. John"s wort

Contact your doctor or health care provider right away if any of these apply to you.

Before using Yasmin :

Some medical conditions may interact with Yasmin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are planning to become pregnant or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a family history of breast cancer, or have ever had an abnormal breast x-ray or mammogram
  • if you have a history of depression or migraine headaches
  • if you smoke, or have high blood pressure, seizures, diabetes, obesity, high cholesterol or high triglycerides, pancreatitis, or gallbladder disease
  • if you have a history of scanty or irregular menstrual periods
  • if you are scheduled for surgery or will be on bed rest

Some MEDICINES MAY INTERACT with Yasmin . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Azole antifungals (eg, ketoconazole), aprepitant, bosentan, barbiturates (eg, phenobarbital), carbamazepine, felbamate, griseofulvin, HIV protease inhibitors (eg, indinavir), hydantoins (eg, phenytoin), modafinil, nevirapine, penicillins (eg, amoxicillin), rifampin, St. John"s wort, tetracyclines (eg, doxycycline), topiramate, or troglitazone because they may decrease Yasmin "s effectiveness
  • Beta-adrenergic blockers (eg, metoprolol), corticosteroids (eg, prednisone), cyclosporine, lamotrigine, selegiline, succinylcholine, theophyllines (eg, aminophylline), or troleandomycin because their actions and the risk of their side effects may be increased by Yasmin
  • Acetaminophen or anticoagulants (eg, warfarin) because their actions may be decreased and the risk of their side effects may be increased by Yasmin

This may not be a complete list of all interactions that may occur. Ask your health care provider if Yasmin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Yasmin :

Use Yasmin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Yasmin . Talk to your pharmacist if you have questions about this information.
  • Take Yasmin by mouth with or without food.
  • To achieve maximum effectiveness of Yasmin , it must be taken every day (every 24 hours) and at the same time each day.
  • Remember to take all of the pills in the pack. Do not skip any doses.
  • Be sure to have an extra full pack of this medication available at all times.
  • If you miss 1 tablet during the first 3 weeks of the pack, take the tablet as soon as you remember. If you miss 2 tablets during the first or second week of the pack, take 2 tablets the day you remember and 2 tablets the next day; then continue to take 1 pill every day until you finish the pack. You should use a backup method (additional type) of birth control if you have sex in the 7 days after missing a pill. If you miss 2 pills during the third week of the pack or if you miss 3 pills in a row during any of the first 3 weeks of the pack, you should continue to take a pill every day until Sunday. On Sunday, you should throw the rest of the pack and start a new pack that same day. Be sure to use a backup method (additional type) of birth control if you have sex in the 7 days after missing a pill. If you have any questions, contact your doctor, nurse, or pharmacist.

Ask your health care provider any questions you may have about how to use Yasmin .

Important safety information:

  • Yasmin may cause dizziness or changes in vision. These effects may be worse if you take it with alcohol or certain medicines. Use Yasmin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • If you miss your period during the week of inactive pills, call your doctor immediately. A missed period may indicate that you are pregnant.
  • Additional monitoring of your dose or condition may be needed if you are taking an angiotensin-converting enzyme (ACE) inhibitor (eg, lisinopril), carvedilol, pioglitazone, certain "water pills" (eg, spironolactone, triamterene), or a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen, naproxen).
  • Yasmin may cause dark skin patches on your face. Exposure to the sun may make these patches darker. If patches develop, use a sunscreen or protective clothing when exposed to the sun, sunlamps, or tanning booths.
  • Follow your doctor"s instructions for examining your own breasts, and report any lumps immediately.
  • Yasmin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Yasmin .
  • If you will be having surgery or will be confined to a chair or bed for a long period of time (such as a long plane flight), notify your doctor 3 to 4 weeks beforehand. Special precautions may need to be taken in these circumstances while you are taking Yasmin .
  • Bleeding or spotting may occur while taking Yasmin . Do not stop taking Yasmin if this occurs. If bleeding or spotting continues for more than 7 days or is heavy, contact your doctor.
  • Smoking cigarettes while using Yasmin may increase your risk of stroke, heart attack, blood clots, high blood pressure, or other diseases of the heart and blood vessels.
  • Vomiting, diarrhea, or taking certain antibiotics or anticonvulsants while you are using Yasmin may decrease the effectiveness of Yasmin . To prevent pregnancy, use an additional form of birth control (eg, condoms, spermicide, diaphragm) until your next period. If you have any questions, contact your doctor, nurse, or pharmacist.
  • If you wear contact lenses and you develop problems with them, contact your doctor.
  • Use of Yasmin will not prevent the spread of sexually transmitted diseases (STDs).
  • Lab tests will be performed while you are taking Yasmin . You will need to have follow-up exams at least once per year. Be sure to keep all doctor and lab appointments.
  • Yasmin should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use Yasmin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Continue to use another method of birth control (eg, condoms). Yasmin is found in breast milk. Do not breast-feed while you are taking Yasmin . Do not take Yasmin soon after delivery of a baby, even if you are not breast-feeding. You should wait 4 weeks after delivery if you are not breast-feeding or 4 weeks after a second trimester abortion.

Possible side effects of Yasmin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Change in appetite; bleeding or spotting between menstrual periods; breast tenderness; change in or absence of menstrual flow; loss of scalp hair; nausea; nervousness or mental depression; reduction of breast milk when given right after childbirth; spotty darkening of the skin, especially the face; stomach cramps or bloating; weight change.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); breast lumps; calf/leg pain or swelling; changes in vision; chest pain or heaviness in the chest; coughing up blood; dark urine or light-colored bowel movements; difficulty wearing contact lenses; dizziness or fainting; fever; headache or migraine; loss of appetite; lumps in the breast; missed menstrual period; mood/mental changes; numbness of an arm or leg; persistent or recurrent abnormal vaginal bleeding; severe pain or tenderness in the stomach area; sleeplessness; slurred speech; sudden severe headache (migraine); sudden shortness of breath; swelling of fingers or ankles; trouble breathing or shortness of breath; vaginal infections; vomiting; weakness or fatigue; weakness or numbness in the arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include nausea; vaginal withdrawal bleeding; vomiting.

Proper storage of Yasmin :

Store Yasmin at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Yasmin out of the reach of children and away from pets.

General information:

  • If you have any questions about Yasmin , please talk with your doctor, pharmacist, or other health care provider.
  • Yasmin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Yasmin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition
Copyright © 2006 Wolters Kluwer Health, Inc.

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Typical mistypes for Yasmin
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