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BROMFENAC (Ophthalmic)

Some commonly used brand names are:

In the U.S.—

  • Xibrom

Not commercially available in Canada.


  • Anti-inflammatory, nonsteroidal (ophthalmic)


Bromfenac (BROME-fen-ak) is a drug used to treat inflammation of the eye following cataract surgery.

This medicine is available only with your doctor"s prescription, in the following dosage forms:

  • Ophthalmic
  • Ophthalmic solution (eye drops) (U.S.)

Before Using This Medicine

In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ophthalmic bromfenac, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to bromfenac. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives or dyes.

Pregnancy—Ophthalmic bromfenac has not been studied in pregnant women. However, studies in animals have shown that bromfenac causes embryo-fetal lethality, increased neonatal mortality, and reduced postnatal growth in rats and post-implantation loss in rabbits. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding—It is not known whether ophthalmic bromfenac passes into breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor.

Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of ophthalmic bromfenac in children with use in other age groups.

Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of ophthalmic bromfenac in the elderly with use in other age groups, this medicine has been used mostly in elderly patients and is not expected to cause different side effects or problems than it does in younger adults.

Other medical problems—The presence of other medical problems may affect the use of bromfenac. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bleeding problems of the eye—May be worsened by bromfenac
  • Corneal denervation or
  • Corneal epithelial defects or
  • Diabetes mellitus or
  • Ocular surface diseases (e.g., dry eyes) or
  • Ocular surgeries, complicated or
  • Ocular surgeries, multiple within a short period of time or
  • Rheumatoid arthritis—May increase the risk of experiencing corneal problems
  • Allergy to sulfites—May cause allergic-type reactions

Proper Use of This Medicine

To use:

  • The bottle is only partially full to provide proper drop control.
  • First, wash your hands. Tilt the head back and, pressing your finger gently on the skin just beneath the lower eyelid away from the eye to make a space. Drop the medicine into this space. Let go of the eyelid and gently close the eyes. Do not blink. Keep the eyes closed and apply pressure to the inner corner of the eye with your finger for 1 or 2 minutes to allow the medicine to be absorbed by the eye
  • Immediately after using the eye drops, wash your hands to remove any medicine that may be on them.
  • To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, keep the container tightly closed. Serious damage to the eye and possible loss of vision may result from using contaminated eye drops.

Dosing—The dose of ophthalmic bromfenac will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of ophthalmic bromfenac. If your dose is different, do not change it unless your doctor tells you to do so.

The number of eye drops that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking bromfenac

  • For ophthalmic dosage form (solution):
    • For eye inflammation following cataract surgery:
      • Adults—1 drop to the problem eye 2 times a day; treatment should start 24 hours after surgery and continue for 2 weeks
      • Children—Use and dose must be determined by your doctor.

Missed dose— If you miss a dose of this medicine, apply it as soon as possible. Then, go back to your regular dosing schedule.

Storage—To store this medicine:

  • Keep out of the reach of children.
  • Store at room temperature.

Precautions While Using This Medicine

If your symptoms do not improve within a few days or if they become worse, check with your doctor.

While applying the medicine, your eyes will probably sting or burn for a short time. This is to be expected.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Incidence not determined—observed during clinical practice, estimates of frequency can not be determined

Vision changes

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Abnormal sensation in eye; burning or stinging of the eye; eye irritation; eye pain; eye redness; headache; increase in blood flow to the whites of the eyes; itching of the eyes; sensitivity to light; tearing; throbbing pain

Incidence not determined—observed during clinical practice, estimates of frequency can not be determined

Blurred vision or other changes in vision

Developed: 06/13/2005

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Typical mistypes for Xibrom
zibrom, cibrom, dibrom, sibrom, xubrom, xjbrom, xkbrom, xobrom, x9brom, x8brom, xivrom, xinrom, xihrom, xigrom, xibeom, xibdom, xibfom, xibtom, xib5om, xib4om, xibrim, xibrkm, xibrlm, xibrpm, xibr0m, xibr9m, xibron, xibrok, xibroj, ibrom, xbrom, xirom, xibom, xibrm, xibro, ixbrom, xbirom, xirbom, xiborm, xibrmo, xxibrom, xiibrom, xibbrom, xibrrom, xibroom, xibromm, etc.

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