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VFEND, |VFEND Vfend

VFEND

Generic Name: voriconazole (vor ih KON a zole)
Brand Names: VFEND

What is voriconazole?

Voriconazole is an antifungal medication.

Voriconazole is used to treat infections caused by yeast or other types of fungus.

Voriconazole may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about voriconazole?

Voriconazole can cause problems with your vision. If you use this medicine for more than 28 days, you may need to have your eyes checked.

Use this medication exactly as it was prescribed for you. Do not use it in larger amounts or for longer than recommended by your doctor.

If you miss a dose, use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.

There are many drugs that can cause dangerous serious or life-threatening drug interactions with voriconazole. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

What should I discuss with my healthcare provider before taking voriconazole?

• terfenadine (Seldane);

• astemizole (Hismanal);

• cisapride (Propulsid);

• pimozide (Orap);

• quinidine (Cardioquin, Quinora, Quinidex, Quinaglute, Quin-Release, Quin-G);

• sirolimus (Rapamune);

• carbamazepine (Tegretol);

• phenobarbital;

• ritonavir (Norvir);

• efavirenz (Sustiva);

• rifabutin (Mycobutin) or rifampin (Rifadin, Rimactane, Rifater); or

• an ergot medicine such as ergotamine (Ergomar, Cafergot, Ercaf, Wigraine, others) or dihydroergotamine (D.H.E., Migranal).

The drugs listed above can cause dangerous serious or life-threatening drug interactions with voriconazole. Tell your doctor about all other medicines you are using.

Before taking voriconazole, tell your doctor if you have:

• heart rhythm problems;

• a metabolic disorder such as high or low levels of calcium, potassium, or magnesium;

• heart rhythm problems;

• liver disease;
• kidney disease; or

• a history of allergy to other antifungal antibiotics such as fluconazole (Diflucan), ketoconazole (Nizoral), or itraconazole (Sporanox).

If you have any of these conditions, you may not be able to use voriconazole, or you may need a dosage adjustment or special tests during treatment.

Voriconazole tablets contain lactose. Before taking a voriconazole tablet, tell your doctor if you have a hereditary form of galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption.

How should I take voriconazole?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

To be sure this medication is helping your condition, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled visits to your doctor.

Voriconazole can cause problems with your vision. If you use this medicine for more than 28 days, you may need to have your eyes checked.

What happens if I miss a dose?

Use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Symptoms of an voriconazole overdose may include vision problems, excessive mouth watering, enlarged pupils, weakness, loss of balance, shortness of breath, or seizure (convulsions).

What should I avoid while taking voriconazole?

Voriconazole side effects

Some people receiving a voriconazole injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, itchy, or have a fast heartbeat, chest tightness, or trouble breathing during the injection.

• sudden behavior changes, problems with thinking or speech;

• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

• urinating less than usual;

• a red, blistering, peeling skin rash; or

• uneven heart rate, chest pain, general ill feeling.

Keep taking voriconazole and talk with your doctor if you have any of these less serious side effects:

• vision problems such as blurred vision, eyes being more sensitive to light;

• fever;

• mild nausea, vomiting, or diarrhea;

• headache; or

• swelling in your hands, ankles, or feet.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect voriconazole?

Before taking voriconazole, tell your doctor if you are using any of the following drugs:

• phenytoin (Dilantin);

• cyclosporine (Sandimmune, Neoral);

• methadone (Methadose);

• tacrolimus (Prograf);

• warfarin (Coumadin);

• stomach acid reducers such as esomeprazole (Nexium), omeprazole (Prilosec), lansoprazole (Prevacid), or pantoprazole (Protonix);

• tranquilizers or sedatives such as alprazolam (Xanax), estazolam (Prosom), flurazepam (Dalmane), midazolam (Versed), or triazolam (Halcion);

• cholesterol-lowering medicines such as atorvastatin (Lipitor), lovastatin (Mevacor), pravastatin (Pravachol), or simvastatin (Zocor);

• vinblastine(Velban), vincristine (Oncovin), or vinorelbine (Navelbine);

• a calcium channel blocker such as verapamil (Isoptin, Verelan, Calan, Covera), amlodipine (Norvasc), felodipine (Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop), or nisoldipine (Sular); or

• an oral diabetes medicine such as glipizide (Glucotrol), glyburide (DiaBeta, Micronase), tolbutamide (Orinase), tolazamide (Tolinase), or chlorpropamide (Diabinese).

If you are using any of these drugs, you may not be able to use voriconazole, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect voriconazole. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist has information about voriconazole written for health professionals that you may read.

What does my medication look like?

Voriconazole is available with a prescription under the brand name VFEND. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• VFEND 50 mg-round, white, film-coated tablets

• VFEND 200 mg-white, capsule-shaped, film-coated tablets

• VFEND oral suspension 40 mg/mL

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.