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Generic Name: Conivaptan (koe-NYE-vap-tan)
Brand Name: Vaprisol

Vaprisol is used for:

Treating low blood sodium levels caused by certain conditions in patients with healthy blood volume.

Vaprisol is an arginine vasopressin receptor antagonist. It works by increasing fluid excretion from the body, which helps to normalize blood sodium levels.

Do NOT use Vaprisol if:

  • you are allergic to any ingredient in Vaprisol
  • you have low blood sodium levels along with low blood or fluid volume
  • you are taking ketoconazole, itraconazole, clarithromycin, ritonavir, or indinavir

Contact your doctor or health care provider right away if any of these apply to you.

Before using Vaprisol :

Some medical conditions may interact with Vaprisol . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have congestive heart failure, liver problems, or kidney problems

Some MEDICINES MAY INTERACT with Vaprisol . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Clarithromycin, indinavir, itraconazole, ketoconazole, or ritonavir because they may increase the risk of side effects from Vaprisol
  • Digoxin because the risk of side effects may be increased
  • HMG-CoA reductase inhibitors (eg, atorvastatin) because the risk of muscle problems may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Vaprisol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Vaprisol :

Use Vaprisol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Vaprisol is usually administered as an injection at your doctor"s office, hospital, or clinic. If you are using Vaprisol at home, carefully follow the injection procedures taught to you by your health care provider.
  • If Vaprisol contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of Vaprisol , contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Vaprisol .

Important safety information:

  • Vaprisol may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Vaprisol . Using Vaprisol alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Vaprisol may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.
  • Diabetes patients - Vaprisol may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.
  • LAB TESTS, including blood sodium levels and neurologic tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Vaprisol with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Vaprisol may cause harm to the fetus. If you think you may be pregnant, discuss with your doctor the benefits and risks of using Vaprisol during pregnancy. It is unknown if Vaprisol is excreted in breast milk. If you are or will be breast-feeding while you are using Vaprisol , check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Vaprisol :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dry mouth; headache; increased thirst; nausea; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; confusion; drowsiness; fast or irregular heartbeat; fever; increased or painful urination; increased sweating; mental or mood changes; pain, irritation, or swelling at injection site; rapid breathing; severe or persistent dizziness; severe or persistent increase in thirst; tremor; unusual tiredness or weakness; white patches in the mouth.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Symptoms may include severe or persistent dizziness; severe or persistent increase in thirst.

Proper storage of Vaprisol :

Vaprisol is usually handled and stored by a health care provider. If you are using Vaprisol at home, store Vaprisol as directed by your pharmacist or health care provider. Keep Vaprisol out of the reach of children and away from pets.

General information:

  • If you have any questions about Vaprisol , please talk with your doctor, pharmacist, or other health care provider.
  • Vaprisol is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Vaprisol . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition
Copyright © 2006 Wolters Kluwer Health, Inc.

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