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Hiprex, Mandelamine, Urex, |Urex

Urex

Generic Name: methenamine (meh THEH na meen)
Brand Names: Hiprex, Mandelamine, Urex

What is methenamine?

Methenamine is a urinary antiinfective medicine. Methenamine fights bacteria in the urine and bladder.

Methenamine may be used to treat and prevent urinary tract infections.

Methenamine may also be used for purposes other than those listed here.

What is the most important information I should know about methenamine?

Your healthcare provider may recommend drinking additional water and/or certain fruit juices (e.g., cranberry, plum, prune) and increased protein in the diet while taking methenamine to ensure adequate hydration and acidity of the urine. It may also be recommended to avoid citrus fruits and juices (e.g., orange, grapefruit, lemon), milk and dairy products, and antacids during treatment with methenamine. These products may decrease the effectiveness of methenamine. Follow your healthcare provider"s instructions.

What should I discuss with my healthcare provider before taking methenamine?

Before taking methenamine, talk to your doctor if you

• have liver problems;
• have kidney problems;

• have other medical conditions; or

• take other medications.

You may not be able to take methenamine, or you may require a dosage adjustment or special monitoring during treatment.

How should I take methenamine?

Take methenamine exactly as directed by your doctor. If you do not understand these instructions, ask your doctor, nurse, or pharmacist to explain them to you.

It is important to take methenamine at regularly scheduled intervals to get the most benefit.

Your healthcare provider may recommend drinking additional water and/or certain fruit juices (e.g., cranberry, plum, prune) and increased protein in the diet while taking methenamine to ensure adequate hydration and acidity of the urine. It may also be recommended to avoid citrus fruits and juices (e.g., orange, grapefruit, lemon), milk and dairy products, and antacids during treatment with methenamine. These products may decrease the effectiveness of methenamine. Follow your healthcare provider"s instructions.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor.

What happens if I overdose?

Symptoms of a methenamine overdose are not known.

What should I avoid while taking methenamine?

Your healthcare provider may recommend drinking additional water and/or certain fruit juices (e.g., cranberry, plum, prune) and increased protein in the diet while taking methenamine to ensure adequate hydration and acidity of the urine. It may also be recommended to avoid citrus fruits and juices (e.g., orange, grapefruit, lemon), milk and dairy products, and antacids during treatment with methenamine. These products may decrease the effectiveness of methenamine. Follow your healthcare provider"s instructions.

Methenamine side effects

• an allergic reaction (shortness of breath; closing of the throat; swelling of the lips, face, or tongue; or hives;

• lower back or side pain;

• blood in urine; or

• increasingly painful or difficult urination.

Other, less serious side effects may be more likely to occur. Continue to take methenamine and talk to your doctor if you experience

• nausea or upset stomach;

• decreased appetite; or

• skin rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect methenamine?

• a carbonic anhydrase inhibitor such as acetazolamide (Diamox), dichlorphenamide (Daranide), or methazolamide (Glauctabs, MZM, Neptazane);

• a sulfa product such as sulfadiazine, sulfamethoxazole (Bactrim, Septra, others), sulfasalazine (Azulfidine), and others;

• a diuretic (water pill); or

• a product that contains aluminum, calcium, magnesium, sodium bicarbonate, potassium or sodium citrate, or citric acid (such as antacids, vitamin or mineral pills, urinary alkalinizers, and other medications).

You may not be able to take methenamine, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with methenamine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

• Your pharmacist has additional information about methenamine written for health professionals that you may read.

What does my medication look like?

Methenamine is available with a prescription under the brand names Hiprex, Urex, and Mandelamine. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.