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|Ureaphil

UREA (Intra-amniotic)†

Some commonly used brand names are:

In the U.S.—

• Ureaphil

Another commonly used name is carbamide .

† Not commercially available in Canada.

Category

• Abortifacient

Description

Intra-amniotic urea (yoor-EE-a) is given by injection into the uterus to cause abortion. It is to be administered only by or under the immediate care of your doctor. It is available in the following dosage form:

• Parenteral
• Injection (U.S.)

Before Receiving This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For urea, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to urea. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Children—Although there is no specific information comparing use of urea in teenagers with use in other age groups, this medicine is not expected to cause different side effects or problems in teenagers than it does in adults.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other medical problems—The presence of other medical problems may affect the use of urea. Make sure you tell your doctor if you have any other medical problems, especially:

• Diabetes mellitus (sugar diabetes)

• Fibroid tumors of the uterus

• Kidney disease

• Liver disease

• Sickle cell disease

Proper Use of This Medicine

During the abortion procedure, you should drink fluids to help prevent your body from losing too much water.

Dosing—The dose of urea will be different for different patients. Follow your doctor"s orders . The dose will be given by your doctor in a health care setting, such as a hospital or clinic. The following information includes only the average doses of urea.

• For injection dosage form:
  • For causing abortion:
    • Adults and teenagers—Up to 250 milliliters (mL) injected through the abdomen into the uterus after the same amount of fluid is taken out of the bag around the fetus (amniotic sac). The injection may be repeated 48 hours after the first dose if needed.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Other side effects may occur that usually do not need medical attention. However, check with your health care professional if any of the following side effects continue or are bothersome:

After the procedure is completed, this procedure may still produce some side effects that need medical attention. Check with your doctor if you notice any of the following side effects:

Chills or shivering; fever; foul-smelling vaginal discharge; increase in bleeding of the uterus; pain in lower abdomen

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your health care professional.

Revised: 02/22/2000

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