Truvada

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|Truvada

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Truvada


Generic Name: Emtricitabine/Tenofovir (em-trih-SYE-ta-bean/te-NOE-fo-veer)
Brand Name: Truvada

Lactic acidosis (buildup of an acid in the blood) has been reported with this type of medicine. Notify your doctor immediately if you experience extreme weakness or tiredness; unusual muscle pain; difficulty breathing; stomach pain with nausea and vomiting; feeling cold, especially in the arms and legs; dizziness or lightheadedness; or fast or irregular heartbeat. Severe liver problems have been reported with this type of medicine. Notify your doctor immediately if you experience yellowing of the skin or eyes; dark urine; light-colored bowel movements (stools); not feeling like eating for several days; nausea; or stomach pain. Truvada is not for the treatment of hepatitis B virus infection. Severe worsening of hepatitis infection ("flare-ups") has been reported with the use of similar medicines. Patients with both HIV and hepatitis B virus need close medical follow-up for several months after stopping use of Truvada . Do not stop taking Truvada without your doctor"s approval.


Truvada is used for:

Treating HIV infection (the virus that causes AIDS) in combination with other medicines. Truvada is not a cure for HIV or AIDS.

Truvada is an antiviral combination of 2 reverse transcriptase inhibitors. It works by blocking an enzyme, which slows the growth of HIV, the virus that causes AIDS.

Do NOT use Truvada if:

  • you are allergic to any ingredient in Truvada
  • you have a history of abnormal liver function tests, severe liver problems, severe kidney problems, or lactic acidosis

Contact your doctor or health care provider right away if any of these apply to you.

Before using Truvada :

Some medical conditions may interact with Truvada . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have bone problems or kidney problems, including dialysis treatment
  • if you have liver problems, including hepatitis B virus infection

Some MEDICINES MAY INTERACT with Truvada . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Didanosine because the risk of its side effects may be increased by Truvada
  • HIV protease inhibitors (eg, indinavir) because they may increase the risk of Truvada "s side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Truvada may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Truvada :

Use Truvada as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Truvada by mouth with or without food.
  • It is important to not miss any doses of Truvada . Taking Truvada at the same time each day will help you to remember to take it.
  • Continue to take Truvada even if you feel well. Do not miss any doses.
  • If you miss a dose of Truvada , take it as soon as possible. If you do not remember until the next day, skip the missed dose and go back to your regular dosing schedule. Do NOT take more than 1 dose in the same day.

Ask your health care provider any questions you may have about how to use Truvada .

Important safety information:

  • Truvada may cause dizziness or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Truvada with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Certain medicines should not be used with Truvada . Keep a list of all the medicine that you take. Make a new list when medicines are added or stopped. Give copies of this list to all of your health care providers and pharmacist every time you visit your health care provider or fill a prescription.
  • When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking Truvada , even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat.
  • Truvada is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor.
  • Truvada does not stop the spread of HIV to others through blood or sexual contact. Use barrier methods of birth control (eg, condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors.
  • Truvada is not for the treatment of hepatitis B virus. If you have hepatitis B virus and HIV, you will need close medical follow-up for several months after stopping treatment with Truvada . Follow-up includes medical exams and blood tests to check for hepatitis B virus infection that could be getting worse.
  • Ask your doctor if you should take a calcium and vitamin D supplement while you are taking Truvada .
  • LAB TESTS, including liver and kidney function tests and bone mineral density tests, may be performed while you use Truvada . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Truvada should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Truvada while you are pregnant. It is not known if Truvada is found in breast milk. Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or Truvada to the baby. Do not breast-feed while taking Truvada .

Possible side effects of Truvada :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal skin sensations; back pain; changes in body fat (eg, increased fat in the upper back and stomach areas, decreased fat in the face, arms, and legs); cough; diarrhea; gas; headache; indigestion; lightening of the skin color on the palms of hands or soles of feet; loss of appetite; nausea; sinus drainage; skin discoloration (small spots or freckles); sleeplessness; strange dreams; sweating; vomiting; weakness; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; chills; dark urine; decreased urination or difficulty urinating; dizziness; extreme weakness or tiredness; fast or irregular heartbeat; feeling cold, especially in the arms and legs; fever; increased thirst; increased urination; light-colored bowel movements (stools); lightheadedness; mental or mood changes (eg, depression); muscle aches; not feeling like eating for several days; numbness, burning, pain, or tingling in the hands or feet; pneumonia; rapid breathing; stomach pain with nausea and vomiting; sore throat; unusual muscle pain; unusual tiredness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Proper storage of Truvada :

Store at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Do not use Truvada if the seal over the bottle opening is broken or missing. Keep Truvada in its original container and keep the container tightly closed. Do not keep medicine that is out of date or that you no longer need. If you throw any medicines away, make sure that children or pets cannot find them. Keep Truvada out of the reach of children and away from pets.

General information:

  • If you have any questions about Truvada , please talk with your doctor, pharmacist, or other health care provider.
  • Truvada is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Truvada . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition 06.4.1.002
Copyright © 2006 Wolters Kluwer Health, Inc.




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