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|Trizivir

Trizivir

Trizivir is used for:

Treating HIV infection. Trizivir is used alone or in combination with other medicines.

Trizivir is an antiviral combination. It works by blocking HIV from reproducing.

Do NOT use Trizivir if:

• you are allergic to any ingredient in Trizivir
• you weigh less than 90 pounds
• you have liver problems or the blood disorder lactic acidosis
• you are taking zalcitabine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Trizivir :

Some medical conditions may interact with Trizivir . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have kidney problems, a history of pancreatitis, blood or bone marrow disorders, alcohol dependence, hepatitis B infection, breathing difficulties, nerve disorders, obesity problems, or a weakened immune system
• if you have abdominal pain, diarrhea, nausea, vomiting, cough, sore throat, fever, fatigue, or a rash
• if you are taking any other medicine for HIV infection

Some MEDICINES MAY INTERACT with Trizivir . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Bone marrow suppressors (eg, interferon alpha), cytotoxic agents (eg, cyclophosphamide), ganciclovir, probenecid, or trimethoprim/sulfamethoxazole (TMP-SMZ) because they may increase the risk of Trizivir "s side effects
• Doxorubicin, ribavirin, stavudine, or zalcitabine because the effectiveness of both medicines may be decreased
• Methadone because its effectiveness may be decreased by Trizivir

This may not be a complete list of all interactions that may occur. Ask your health care provider if Trizivir may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Trizivir :

Use Trizivir as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Trizivir comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Trizivir refilled.
• Take Trizivir by mouth with or without food.
• Continue to take Trizivir even if you feel well. Do not miss any doses.
• If you miss a dose of Trizivir , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Trizivir .

Important safety information:

• Trizivir may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Trizivir with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Trizivir is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor.
• When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking Trizivir , even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat.
• Trizivir does not stop the spread of HIV to others through blood or sexual contact. Use barrier methods of birth control (eg, condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors.
• Trizivir contains abacavir, lamivudine, and zidovudine. Before you start any new medicine, check the label to see if it has abacavir, lamivudine, and zidovudine in it too. If it does or if you are not sure, check with your doctor or pharmacist.
• Carry an ID card at all times that says you take Trizivir .
• Changes in body fat (eg, an increased amount of fat in the upper back, neck, breast, and trunk, and loss of fat from the legs, arms, and face) may occur in some patients taking Trizivir . The cause and long-term effects of these changes are unknown. Discuss any concerns with your doctor.
• Diabetes patients - Trizivir may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• Lab tests, including complete blood cell counts and liver function tests, may be performed while you use Trizivir . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Trizivir should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Trizivir while you are pregnant. Trizivir is found in breast milk. Do not breast-feed while taking Trizivir . Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or Trizivir to the baby.

Possible side effects of Trizivir :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal skin sensations; chills; depression; dizziness; general body discomfort; headache; indigestion; joint pain; lack of energy; loss of appetite; muscle pain; sleeplessness; stomach cramps.

Severe allergic reactions (fever; rash; tiredness; achiness; nausea; diarrhea; vomiting; stomach pain; sore throat; hives; itching; difficulty breathing; cough; tightness in the chest; swelling of the mouth, face, lips, or tongue); excess eye mucus; exhaustion; fainting; flu-like illness; mouth ulcers; numbness, tingling, or pain in hands and feet; seizures; severe dizziness; severe muscle, stomach, or chest pain or cramping; unusual weakness.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include confusion; drowsiness; nausea; seizures; tiredness; vomiting.

Store Trizivir at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Trizivir out of the reach of children and away from pets.

General information:

• If you have any questions about Trizivir , please talk with your doctor, pharmacist, or other health care provider.
• Trizivir is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Trizivir . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.