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|Trimethobenzamide/Benzocaine Suppositories

Trimethobenzamide/Benzocaine Suppositories

Trimethobenzamide/Benzocaine Suppositories is used for:

Treating nausea and vomiting. It may also be used for other conditions as determined by your doctor.

Trimethobenzamide/Benzocaine Suppositories is an antiemetic. It works by blocking one of the chemical messengers that stimulates nausea and vomiting.

Do NOT use Trimethobenzamide/Benzocaine Suppositories if:

• you are allergic to any ingredient in Trimethobenzamide/Benzocaine Suppositories, including benzocaine, or similar anesthetics
• you are currently taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Trimethobenzamide/Benzocaine Suppositories:

Some medical conditions may interact with Trimethobenzamide/Benzocaine Suppositories. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, plan to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a brain disease, dehydration, electrolyte disturbance, fever, stomach or intestinal/bowel irritation, or Reye syndrome

Some MEDICINES MAY INTERACT with Trimethobenzamide/Benzocaine Suppositories. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Sodium oxybate (GHB) because serious side effects, including increased risk of increased sleep duration and drowsiness leading to unconsciousness or coma, may be increased by Trimethobenzamide/Benzocaine Suppositories

This may not be a complete list of all interactions that may occur. Ask your health care provider if Trimethobenzamide/Benzocaine Suppositories may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Trimethobenzamide/Benzocaine Suppositories:

Use Trimethobenzamide/Benzocaine Suppositories as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• If the suppository is too soft to use, put it in the refrigerator for about 15 minutes or run cold water over it. Then remove the wrapper and moisten the suppository with cool water. Lie down on your side. Use your finger to push the pointed end of the suppository well up into the rectum. Wash your hands thoroughly after using Trimethobenzamide/Benzocaine Suppositories.
• If you miss a dose of Trimethobenzamide/Benzocaine Suppositories and you are taking it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Trimethobenzamide/Benzocaine Suppositories.

Important safety information:

• Trimethobenzamide/Benzocaine Suppositories may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Trimethobenzamide/Benzocaine Suppositories. Using Trimethobenzamide/Benzocaine Suppositories alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
• Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Trimethobenzamide/Benzocaine Suppositories. Trimethobenzamide/Benzocaine Suppositories will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
• If your symptoms do not improve within a few days or if they become worse, check with your doctor.
• Do not use Trimethobenzamide/Benzocaine Suppositories for future conditions without checking with your doctor.
• Involuntary and uncontrollable movements may develop in patients taking Trimethobenzamide/Benzocaine Suppositories. Contact your health care provider at once if any of the following occur: involuntary movements of tongue, face, mouth or jaw (eg, protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements), sometimes accompanied by involuntary movements of the arms and legs; shuffling walk; tremors or shakiness; or slow, jerking movements.
• Use Trimethobenzamide/Benzocaine Suppositories with caution in the ELDERLY because they may be more sensitive to its effects, especially dizziness.
• Do not give CHILDREN Trimethobenzamide/Benzocaine Suppositories to treat vomiting when the cause of vomiting is unknown. Trimethobenzamide/Benzocaine Suppositories may contribute to the development of Reye syndrome, a rare but serious illness. Trimethobenzamide/Benzocaine Suppositories is not recommended for use in PREMATURE INFANTS or NEWBORN INFANTS younger than 4 weeks of age. Safety and effectiveness in this age group have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using Trimethobenzamide/Benzocaine Suppositories during pregnancy. It is unknown if Trimethobenzamide/Benzocaine Suppositories is excreted in breast milk. If you are or will be breast-feeding while you are using Trimethobenzamide/Benzocaine Suppositories, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Trimethobenzamide/Benzocaine Suppositories:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; rectal irritation.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); loss of balance; seizures; shuffling walk; uncontrolled movements of the arms or legs; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Store Trimethobenzamide/Benzocaine Suppositories in the sealed wrapper at room temperature, 77 degrees F (25 degrees C), away from heat, moisture, and light. Do not store in the bathroom. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Keep Trimethobenzamide/Benzocaine Suppositories out of the reach of children and away from pets.

General information:

• If you have any questions about Trimethobenzamide/Benzocaine Suppositories, please talk with your doctor, pharmacist, or other health care provider.
• Trimethobenzamide/Benzocaine Suppositories is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Trimethobenzamide/Benzocaine Suppositories. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.