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|Trandolapril, Verapamil hydrochloride

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Trandolapril, Verapamil hydrochloride

Generic name: Trandolapril, Verapamil hydrochloride
Brand names: Tarka

Why is Trandolapril, Verapamil hydrochloride prescribed?

Trandolapril, Verapamil hydrochloride is used to treat high blood pressure. It combines two blood pressure drugs: an ACE inhibitor and a calcium channel blocker. The ACE inhibitor (trandolapril) lowers blood pressure by preventing a chemical in your blood called angiotensin I from converting to a more potent form that narrows the blood vessels and increases salt and water retention. The calcium channel blocker (verapamil hydrochloride) also works to keep the blood vessels open, and eases the heart"s workload by reducing the force and rate of your heartbeat.

Most important fact about Trandolapril, Verapamil hydrochloride

Doctors usually prescribe Trandolapril, Verapamil hydrochloride for patients who have been taking one of its components-trandolapril (Mavik) or sustained-release verapamil (Calan SR, Isoptin SR)-without showing improvement. Like other blood pressure medications, Trandolapril, Verapamil hydrochloride must be taken regularly for it to be effective. Since blood pressure declines gradually, it may take a few weeks before you get the full benefit of Trandolapril, Verapamil hydrochloride; and you must continue taking it even if you are feeling well. Trandolapril, Verapamil hydrochloride does not cure high blood pressure; it merely keeps it under control.

How should you take Trandolapril, Verapamil hydrochloride?

Take each dose with food, exactly as prescribed.

--If you miss a dose...

Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

--Storage instructions...

Keep the container tightly closed. Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Trandolapril, Verapamil hydrochloride.

More common side effects may include:
Constipation, cough, dizziness, headache, heartbeat irregularities, upper respiratory tract infection

Why should Trandolapril, Verapamil hydrochloride not be prescribed?

Avoid Trandolapril, Verapamil hydrochloride if you have ever had an allergic reaction to it, or to verapamil or any of the ACE inhibitors, including Capoten, Vasotec, and Zestril.

You should also avoid Trandolapril, Verapamil hydrochloride if you have low blood pressure or certain types of heart disease or irregular heartbeat. Make sure your doctor is aware of any cardiac problems you may have.

In addition, Trandolapril, Verapamil hydrochloride is not for you if you have ever developed a swollen throat and difficulty swallowing (angioedema) while taking an ACE inhibitor. Make sure your doctor is aware of the incident.

Special warnings about Trandolapril, Verapamil hydrochloride

Call your doctor immediately if you begin to suffer angioedema while taking Trandolapril, Verapamil hydrochloride. Warning signs include swelling of the face, lips, tongue, or throat; swelling of the arms and legs; and difficulty swallowing or breathing.

Bee or wasp venom given to prevent an allergic reaction to stings may cause a severe allergic reaction to Trandolapril, Verapamil hydrochloride. Kidney dialysis can also prompt an allergic reaction to the drug.

Trandolapril, Verapamil hydrochloride sometimes causes a severe drop in blood pressure. The danger is especially great if you have been taking water pills (diuretics), or if you have heart disease, kidney disease, or a potassium or salt imbalance. Excessive sweating, severe diarrhea, and vomiting are also a threat. They can rob the body of water, causing a dangerous drop in blood pressure. If you feel light-headed or faint, you should lie down and contact your doctor immediately.

Because another of the ACE inhibitors, Capoten, has been known to cause serious blood disorders, your doctor will check your blood regularly while you are taking Trandolapril, Verapamil hydrochloride. If you develop signs of infection such as a sore throat or a fever, you should contact your doctor at once-an infection could be a signal of blood abnormalities.

Trandolapril, Verapamil hydrochloride may also affect the liver, so your doctor will perform liver function tests periodically. Report these symptoms of liver problems to your doctor immediately: a generally run-down feeling, fever, pain in the upper right abdomen, or yellowing of the skin or the whites of your eyes.

If you have a heart condition, heart failure, cardiac irregularities, kidney disease, liver disease, diabetes, or Duchenne"s dystrophy (the most common type of muscular dystrophy), make certain that your doctor knows about it. Trandolapril, Verapamil hydrochloride should be used with caution under these circumstances.

Possible food and drug interactions when taking Trandolapril, Verapamil hydrochloride

If Trandolapril, Verapamil hydrochloride is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Trandolapril, Verapamil hydrochloride with the following:

Drugs classified as "beta blockers," such as Inderal, Lopressor, and Tenormin
Carbamazepine (Tegretol)
Cimetidine (Tagamet)
Cyclosporine (Sandimmune, Neoral)
Digoxin (Lanoxin)
Disopyramide (Norpace)
Diuretics such as Lasix and HydroDIURIL
Flecainide (Tambocor)
Lithium (Lithonate, Lithobid)
Phenobarbital
Potassium-sparing diuretics such as Aldactone, Midamor, Dyrenium
Potassium supplements such as K-Lyte, K-Tabs, and Slow-K
Quinidine (Quinidex)
Rifampin (Rifadin)
Theophylline (Theo-Dur)

Because Trandolapril, Verapamil hydrochloride can increase the potassium level in your blood, you should avoid salt substitutes that contain potassium unless your doctor approves.

Special information if you are pregnant or breastfeeding

Because of its ACE-inhibitor component (trandolapril), Trandolapril, Verapamil hydrochloride should not be used during pregnancy. When taken during the last 6 months of pregnancy, ACE inhibitors can cause birth defects, premature birth, and death of the developing or newborn baby. If you become pregnant, inform your doctor immediately.

The verapamil component of Trandolapril, Verapamil hydrochloride does appear in breast milk and could affect a nursing infant. Do not breastfeed while taking Trandolapril, Verapamil hydrochloride.

Recommended dosage

ADULTS

Trandolapril, Verapamil hydrochloride comes in four strengths of trandolapril and sustained-release verapamil. Your doctor will prescribe a dose of Trandolapril, Verapamil hydrochloride that is comparable to the doses you were taking separately. Doses range from 1 to 4 milligrams of trandolapril and 180 to 240 milligrams of verapamil. Trandolapril, Verapamil hydrochloride is taken once a day with food.

If you have impaired liver or kidney function, your doctor will adjust your dosage accordingly.

CHILDREN

The safety and effectiveness of Trandolapril, Verapamil hydrochloride in children under 18 have not been established.

OLDER ADULTS

If you are over 65 years old, you may be more sensitive to Trandolapril, Verapamil hydrochloride. Your doctor will monitor your blood pressure more closely and adjust your medication dose accordingly.

Overdosage

An overdose of Trandolapril, Verapamil hydrochloride can cause dangerously low blood pressure and life-threatening heart problems. If you suspect an overdose, seek medical treatment immediately.

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