trandolapril and verapamil

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Tarka, |trandolapril and verapamil
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trandolapril and verapamil

Generic Name: trandolapril and verapamil (tran DOLE a pril and ver AP a mill)
Brand Names: Tarka

What is trandolapril and verapamil?

Verapamil is in a class of drugs called calcium channel blockers. Verapamil relaxes (widens) your blood vessels (veins and arteries), which makes it easier for your heart to pump and reduces its workload.

Trandolapril is in a class of drugs called angiotensin-converting-enzyme inhibitors (ACE inhibitors). Trandolapril prevents the constriction (narrowing) of blood vessels (veins and arteries).

Trandolapril and verapamil is used to treat hypertension (high blood pressure).

Trandolapril and verapamil may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about trandolapril and verapamil?

Do not take trandolapril and verapamil if you are pregnant or planning a pregnancy. When used during the second and third trimesters of pregnancy, ACE inhibitors (trandolapril) can cause injury and even death to the developing fetus. Notify your doctor immediately if you think you might be pregnant. Do not stop taking this medication unless your doctor approves. If you stop taking your medication, your condition could become much worse. Use caution when driving, operating machinery, or performing other hazardous activities. Trandolapril and verapamil may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Also use caution when rising from a sitting or lying position.

Heavy sweating, vomiting, diarrhea, or other causes of fluid loss may lead to very low blood pressure, dizziness, and fainting during therapy with trandolapril and verapamil. Maintain proper fluid intake to prevent dehydration and related adverse effects.

Do not break, crush, or chew this medication. Swallow the pills whole.

What should I discuss with my healthcare provider before taking trandolapril and verapamil?

Before taking trandolapril and verapamil, tell your doctor if you

  • have liver disease;
  • have kidney disease;

  • have diabetes;

  • have a collagen vascular disorder;

  • have other diseases of the heart or blood vessels such as sick sinus syndrome, Wolff-Parkinson-White syndrome, Lown-Ganong-Levine syndrome, aortic stenosis, congestive heart failure, heart block, or low blood pressure; or

  • are taking salt substitutes, potassium supplements (e.g., K-Dur, Klor-Con), or a potassium-sparing diuretic such as amiloride (Midamor), triamterene (Dyrenium, Dyazide, Maxzide), or spironolactone (Aldactone).

You may not be able to take trandolapril and verapamil, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Trandolapril and verapamil is in the FDA pregnancy category D. This means that trandolapril and verapamil is known to harm an unborn baby. When used during the second and third trimesters of pregnancy, ACE inhibitors (trandolapril) can cause injury and even death to the developing fetus. Do not take this medication without first talking to your doctor if you are pregnant or planning a pregnancy. Trandolapril and verapamil passes into breast milk and may harm a breast-feeding baby. Do not use trandolapril and verapamil without first talking to your doctor if you are breast-feeding a baby.

How should I take trandolapril and verapamil?

Take trandolapril and verapamil exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Do not break, crush, or chew this medication. Swallow the pills whole. Do not stop taking this medication unless your doctor approves. If you stop taking your medication, your condition could become much worse. Store trandolapril and verapamil at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a trandolapril and verapamil overdose are unknown but might include extreme dizziness, weakness, fainting, fatigue chest pain, shortness of breath, an unusually fast or slow heartbeat, coma, slurred speech, and confusion.

What should I avoid while taking trandolapril and verapamil?

Use caution when driving, operating machinery, or performing other hazardous activities. Trandolapril and verapamil may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Also use caution when rising from a sitting or lying position. Use alcohol cautiously. Alcohol may further lower blood pressure and increase drowsiness and dizziness while you are taking trandolapril and verapamil.

Do not use salt substitutes or potassium supplements while taking trandolapril and verapamil, except under the supervision of your doctor.

Heavy sweating, vomiting, diarrhea, or other causes of fluid loss may lead to very low blood pressure, dizziness, and fainting during therapy with trandolapril and verapamil. Maintain proper fluid intake to prevent dehydration and related side effects.

Grapefruit and grapefruit juice may interact with trandolapril and verapamil. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

Trandolapril and verapamil side effects

If you experience any of the following serious side effects, stop taking trandolapril and verapamil and call your doctor immediately or seek emergency medical treatment:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

  • jaundice (yellowing of your skin or eyes);

  • unusually fast or slow heartbeats;

  • difficulty breathing;

  • abnormal behavior or psychosis;

  • swelling of your legs or ankles;

  • little or no urine;

  • chest pain; or

  • severe dizziness or fainting.

Other, less serious side effects may be more likely to occur. Continue to take trandolapril and verapamil and talk to your doctor if you experience

  • mild dizziness or lightheadedness;

  • headache;

  • dry, tickling cough;

  • flushing (redness);

  • insomnia and vivid dreams;

  • numbness or tingling in the hands, feet, arms, or legs;

  • nausea, constipation, or diarrhea;

  • weakness or fatigue; or

  • a rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect trandolapril and verapamil?

Before taking trandolapril and verapamil, tell your doctor if you are taking any of the following drugs:

  • a potassium supplement such as K-Dur, Klor-Con, and others;

  • a salt substitute that contains potassium;

  • any of the diuretics (water pills) triamterene (Dyrenium, Maxzide, Dyazide), spironolactone (Aldactone), and amiloride (Midamor);

  • any other diuretic (water pill), such as hydrochlorothiazide (HCTZ, Hydrodiuril, others), furosemide (Lasix), bumetanide (Bumex), indapamide (Lozol), and others;

  • a beta-blocker such as atenolol (Tenormin), acebutolol (Sectral), metoprolol (Lopressor, Toprol XL), propranolol (Inderal), carvedilol (Coreg), and others;

  • digoxin, (Lanoxin, Lanoxicaps);

  • disopyramide (Norpace);

  • flecainide (Tambocor);

  • quinidine (Quinaglute, Quinidex, Cardioquin);

  • lithium (Lithobid, Eskalith, others);

  • rifampin (Rifadin, Rifabutin;

  • phenobarbital (Luminal, Solfoton);

  • carbamazepine (Tegretol);

  • theophylline (Theo-Dur, Theochron, Theolair, others); or

  • cyclosporine (Sandimmune, Neoral).

You may not be able to take trandolapril and verapamil, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the drugs listed above.

Drugs other than those listed here may also interact with trandolapril and verapamil or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

  • Your pharmacist has additional information about trandolapril and verapamil written for health professionals that you may read.

What to the pills look like?

Trandolapril and verapamil is available with a prescription under the brand name Tarka. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you. The following product strengths are listed trandolapril/verapamil:

  • Tarka 2/180-pink, oval, film-coated tablets

  • Tarka 1/240-white, oval, film-coated tablets

  • Tarka 2/240-gold, oval, film-coated tablets

  • Tarka 4/240-reddish-brown, oval, film-coated tablets

  • Remember, keep this and all other medicines out of the reach of children. Never share your medicines with others and only use this medication for the condition prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 4.01. Revision Date: 9/28/04 2:28:58 PM.



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