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|Tositumomab And Iodine I 131 Tositumomab |
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† Not commercially available in Canada. Category
DescriptionTositumomab(( tos-IT-too-moe-mab)) and iodine ((EYE-oh-din)) I 131 tositumomab((tos-IT-too-moe-mab)) is a protein called a monoclonal antibody. It is used to treat a type of cancer called non-Hodgkin"s lymphoma. Tositumomab and iodine I 131 tositumomab is to be administered only by or under the immediate supervision of your doctor. It is available in the following dosage form:
Before Using This MedicineIn deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For tositumomab and iodine I 131 tositumomab, the following should be considered: Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to tositumomab, iodine I 131 tositumomab, or mouse proteins. Also tell your doctor and pharmacist if you are allergic to any other substances. Pregnancy—Tositumomab and iodine I 131 tositumomab is not recommended during pregnancy. It has been shown to cause thyroid problems in the baby. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant. Women who are able to bear children should use some kind of birth control during treatment with this medicine and for up to 12 months after treatment has ended. Breast-feeding—This medicine passes into breast milk and may cause unwanted effects in nursing babies. It may be necessary for you to take another medicine or to stop breast-feeding during treatment. Be sure you have discussed the risks and benefits of the medicine with your doctor. Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of tositumomab and iodine I 131 tositumomab in children with use in other age groups. Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of tositumomab and iodine I 131 tositumomab in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults. Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking tositumomab and iodine I 131 tositumomab, it is especially important that your doctor and pharmacist know if you are taking any of the following:
Other medical problems—The presence of other medical problems may affect the use of tositumomab and iodine I 131 tositumomab. Make sure you tell your doctor if you have any other medical problems, or bone marrow problems. Proper Use of This MedicineDosing—The dose of tositumomab and iodine I 131 tositumomab will be different for different patients. The dose that is used may depend on a number of things, including your size. Tositumomab and iodine I 131 tositumomab is usually given by a doctor in the hospital or an outpatient clinic. If you have any questions about the proper dose of tositumomab and iodine I 131 tositumomab, ask your doctor. Precautions While Using This MedicineIt is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects. While you are being treated with tositumomab and iodine I 131 tositumomab, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor"s approval . Tositumomab and iodine I 131 tositumomab may lower your body"s resistance and there is a chance you might get the infection the immunization is meant to prevent. Patients should be informed of the risks of hypothyroidism and be advised to take thyroid blocking agents during treatment. Tositumomab and iodine I 131 tositumomab can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:
Side Effects of This MedicineAlong with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Bleeding gums; bone pain; chills; constipation ; cough; coughing up blood; depressed mood; difficulty breathing; difficulty swallowing; dizziness; dry skin and hair; fast heartbeat; feeling cold; fever or chills; hair loss; headache; hives; hoarseness or husky voice; increased menstrual flow or vaginal bleeding; itching; large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs; lower back or side pain; muscle cramps and stiffness; noisy breathing; nosebleeds ; painful or difficult urination; pale skin; paralysis; pinpoint red spots on skin; prolonged bleeding from cuts; puffiness or swelling of the eyelids or around the eyes, face, lips or tongue; red or dark brown urine; red or black, tarry stools; shortness of breath; skin rash; slowed heartbeat ; sore throat; sores, ulcers, or white spots on lips or in mouth; swollen glands; tightness in chest; troubled breathing with exertion; unusual bleeding or bruising; unusual tiredness or weakness; weight gain; or wheezing Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome. More common Abdominal pain or stomach pain ; acid or sour stomach; belching; blurred vision; body aches or pain; confusion; congestion; diarrhea or increased bowel movements; difficult or labored breathing; difficulty having a bowel movement (stool); difficulty in moving; dryness or soreness of throat; faintness or lightheadedness when getting up from a lying or sitting position ; feeling of warmth or heat; flushing or redness of skin, especially on face and neck; headache; heartburn; indigestion; itching skin; joint pain ; swollen joints; muscle aching or cramping; muscle pains or stiffness; difficulty in moving; lack or loss of strength; loose or liquid stools; muscle pain or stiffness ; nausea or feeling of upset stomach or feeling like you may vomit; pain in joints; runny nose; stomach discomfort, upset or pain; sudden sweating; swelling of hands, ankles, feet, or lower legs; swollen joints; tender, swollen glands in neck; trouble in swallowing; voice changes; vomiting Developed: 04/25/2005 The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Thomson Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Healthcare does not assume any responsibility or risk for your use of the Thomson Healthcare products. Where can I get more information about Tositumomab And Iodine I 131 Tositumomab ? 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