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Aptivus, |tipranavir Tipranavir

tipranavir

Generic Name: tipranavir (tip RA na veer)
Brand Names: Aptivus

What is tipranavir?

Tipranavir is an antiviral medication in a group of HIV medicines called protease (PRO-tee-ayz) inhibitors. Tipranavir prevents human immunodeficiency virus (HIV) cells from multiplying in your body.

Tipranavir is used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS). Tipranavir is not a cure for HIV or AIDS.

Tipranavir may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about tipranavir?

There are many other medicines that can interact with tipranavir.Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

• unusual bleeding (such as a nosebleed or blood in your urine or stools);

• sudden headache, confusion, problems with vision, speech, or balance;

• low fever, nausea, stomach pain, loss of appetite;

• dark urine, clay-colored stools; or

• jaundice (yellowing of the skin or eyes).

What should I discuss with my health care provider before taking tipranavir?

• amiodarone (Cordarone, Pacerone);

• astemizole (Hismanal);

• bepridil (Vascor);

• cisapride (Propulsid);

• flecainide (Tambocor);

• midazolam (Versed) or triazolam (Halcion);

• pimozide (Orap);

• propafenone (Rythmol);

• quinidine (Cardioquin, Quinidex, Quinaglute);

• terfenadine (Seldane); or

• or ergot medicines such as ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine).

Before taking tipranavir, tell your doctor if you are allergic to any drugs, or if you have:

• liver disease (especially hepatitis B or C);

• diabetes;

• a bleeding disorder such as hemophilia; or

• high chlolesterol or triglycerides.

If you have any of these conditions, you may not be able to use tipranavir, or you may need a dosage adjustment or special tests during treatment.

Your name may need to be listed on an antiretroviral pregnancy registry when you start using this medication.

How should I take tipranavir?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

If you also take ritonavir, take it at the same time you take tipranavir unless your doctor has told you otherwise.

It is important to use tipranavir regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

HIV/AIDS is usually treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor. Every person with HIV or AIDS should remain under the care of a doctor.

To be sure this medication is helping your condition, your blood will need to be tested on a regular basis. Your liver function may also need to be tested. Do not miss any scheduled visits to your doctor.

Store an unopened bottle of tipranavir capsules in the refrigerator but do not allow them to freeze. After opening the bottle for the first time, you may store the capsules at room temperature. Throw away any capsules you have not used within 60 days after you first opened the medicine bottle.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

What should I avoid while taking tipranavir?

If you also take didanosine, take it 2 hour before or after you take tipranavir.

Taking tipranavir will not prevent you from passing HIV to other people through unprotected sex or sharing of needles. Talk with your doctor about safe methods of preventing HIV transmission during sex, such as using a condom and spermicide. Sharing drug or medicine needles is never safe, even for a healthy person.

Tipranavir side effects

• unusual bleeding (such as a nosebleed or blood in your urine or stools);

• sudden headache, confusion, problems with vision, speech, or balance;

• low fever, nausea, stomach pain, loss of appetite;

• dark urine, clay-colored stools; or

• jaundice (yellowing of the skin or eyes).

• increased urination or extreme thirst;

• easy bruising or bleeding; or

• signs of a new infection, such as fever or chills, cough, or flu symptoms.

Keep taking the medication and talk with your doctor if you have any of these less serious side effects:

• mild nausea, vomiting, diarrhea, bloating, stomach pain;

• numbness or tingling, especially around your mouth;

• headache, mood changes; or

• changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect tipranavir?

Before taking tipranavir, tell your doctor if you are using any of the following drugs:

• fluticasone (Advair, Flonase, Flovent);

• St. John"s wort;

• antibiotics such as clarithromycin (Biaxin), itraconazole (Sporanox), ketoconazole (Nizoral), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, Rifater);

• antidepressants such as paroxetine (Paxil), sertraline (Zoloft), trazodone (Desyrel), and others;

• a beta-blocker such as metoprolol (Lopressor, Toprol) or timolol (Blocadren);

• a calcium channel blocker such as amlodipine (Caduet, Lotrel, Norvasc), diltiazem (Tiazac, Cartia, Dilacor), felodipine (Plendil), nifedipine (Procardia, Adalat), or verapamil (Calan, Covera, Isoptin, Verelan);

• cholesterol-lowering medicine such as atorvastatin (Lipitor), lovastatin (Mevacor, Altocor), or simvastatin (Zocor);

• drugs that weaken the immune system, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf);

• other HIV /AIDS medicine such as amprenavir (Agenerase), lopinavir/ritonavir (Kaletra), or saquinavir (Invirase);

• insulin or diabetes medication you take by mouth;

• medications that a blood thinner such as warfarin (Coumadin);

• medicines to treat erectile dysfunction, such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra); or

• seizure medications such as carbamazepine (Carbatrol, Tegretol), clonazepam (Klonopin), divalproex (Depakote), ethosuximide (Zarontin), lamotrigine (Lamictal), or phenytoin (Dilantin).

If you are using any of these drugs, you may not be able to take tipranavir, or you may need dosage adjustments or special tests during treatment.

There are many other medicines that can interact with tipranavir. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Where can I get more information?

• Your pharmacist has information about tipranavir written for health professionals that you may read.

What does my medication look like?

Tipranavir is available with a prescription under the brand name Aptivus. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Aptivus 250 mg-- pink, oblong soft gelatin capsule

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