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|Tinidazole Tinidazole

Tinidazole

Generic name: Tinidazole
Brand names: Tindamax

Why is Tinidazole prescribed?

Tinidazole is prescribed to treat infections caused by a variety of parasites, including:

• Trichomoniasis, a common sexually transmitted disease that affects men and women. It can contribute to reduced fertility in both sexes and may enhance the acquisition and transmission of HIV. Trichomoniasis has also been linked to cervical cancer, preterm birth, and postoperative infection. Symptoms in women include yellow or green vaginal discharge (often with a foul odor) and vaginal burning, itching, soreness or redness. Urination and intercourse may also be painful. Men who are infected with trichomoniasis frequently do not have symptoms and often unknowingly transmit the infection to their partner. When symptoms are present in men, they may include urethral discharge and irritation.
• Giardiasis, an intestinal infection caused by drinking untreated water. Symptoms include abdominal pain, nausea, vomiting, diarrhea, cramping, bloating, and weight loss.
• Intestinal amebiasis (commonly known as dysentery), an infection caused by consuming contaminated water or food. Symptoms may include loose stools, stomach pain, and cramping. In more severe cases, symptoms can include severe stomach pain, weight loss, bloody stools, and fever.
• Amebic liver abscess, a severe and potentially life-threatening infection caused by the same parasite that causes intestinal amebiasis. Symptoms may not be detectable. When symptoms do appear, they can include fever, jaundice, loss of appetite, diarrhea, and intense stomach pain, especially in the upper right-hand side near the liver.

Most important fact about Tinidazole

Do not drink alcohol while taking Tinidazole or for 3 days after you stop taking the drug. Combining alcohol with Tinidazole can cause stomach cramps, nausea, vomiting, headaches, and flushing. When Tinidazole is combined with alcohol and the drug disulfiram (Antabuse), a severe mental disorder can occur. Always check the labels on foods and over-the-counter products to make sure they do not contain alcohol.

How should you take Tinidazole?

Take Tinidazole with food at about the same time each day. The drug works best when there"s a constant amount in the bloodstream.

For people who cannot swallow tablets, a pharmacist can make Tinidazole into a syrup.

--If you miss a dose...

Take the forgotten dose as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular schedule. Do not take two doses at once.

--Storage instructions...

Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe to continue using Tinidazole.

• Side effects may include:
  Abdominal pain, appetite loss, bitter or metallic taste, confusion, depression, difficulty breathing, drowsiness, fatigue, headache, loss of consciousness, nausea, skipped heartbeat, vaginal discharge, vomiting, weakness

Although rare, Tinidazole has caused seizures and numbness or tingling in the arms, hands, legs, and feet (see "Special warnings about Tinidazole").

Why should Tinidazole not be prescribed?

Do not use Tinidazole if you have ever had an allergic reaction to other drugs in the same class such as metronidazole (Flagyl).

You should not take Tinidazole within 2 weeks of the drug disulfiram (Antabuse).

Tinidazole should not be used during the first 3 months of pregnancy.

Special warnings about Tinidazole

Use Tinidazole cautiously if you have any disease of the central nervous system. In rare cases, the drug has caused seizures or peripheral neuropathy (a painful nerve disorder marked by numbness or tingling in the arms, hands, legs and feet). If you experience these symptoms, stop taking Tinidazole and call your doctor immediately.

Tinidazole can make some medical conditions worse. If you have a blood disorder, liver disease, or yeast infection, your doctor will monitor you closely during treatment with Tinidazole.

If you"re taking Tinidazole to treat the sexually transmitted disease trichomoniasis, your partner should be treated at the same time to prevent you from getting infected again.

Possible food and drug interactions when taking Tinidazole

Do not combine Tinidazole with alcohol or any product containing alcohol (see "Most important fact about Tinidazole").

If Tinidazole is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Tinidazole with the following:

Blood thinners such as warfarin (Coumadin)
Cholestyramine (Questran, Questran Light)
Cimetidine (Tagamet)
Cyclosporine (Neoral, Sandimmune)
Disulfiram (Antabuse)
Fluorouracil (Adrucil)
Fosphenytoin (Cerebyx)
Ketoconazole (Nizoral)
Lithium (Eskalith, Lithobid)
Oxytetracycline (Terramycin)
Phenobarbital
Phenytoin (Dilantin)
Rifampin (Rifadin, Rimactane)
Tacrolimus (Prograf)

Special information if you are pregnant or breastfeeding

If you are pregnant or plan to become pregnant, inform your doctor immediately. Tinidazole has not been studied in pregnant women. However, because lab and animal studies indicate that Tinidazole does cross the placenta, it should not be used during the first 3 months of pregnancy. Tinidazole should only be used in the last 6 months of pregnancy if your doctor decides the benefits outweigh the risks.

Because Tinidazole appears in breast milk, you should not take it while breastfeeding. If your doctor decides to treat you with Tinidazole, you"ll have to avoid breastfeeding while you"re taking the drug and for 3 days after the last dose.

Recommended dosage

ADULTS

Trichomoniasis

The treatment consists of a single 2-gram dose. Your sexual partner should be treated at the same time.

Giardiasis

The treatment consists of a single 2-gram dose.

Intestinal Amebiasis

The recommended dose is 2 grams a day for 3 days.

Amebic Liver Abscess

The recommended dose is 2 grams a day for 3 to 5 days.

CHILDREN 3 YEARS OF AGE AND OLDER

Giardiasis

The treatment consists of a single dose based on the child"s weight (50 milligrams per 2.2 pounds), up to a maximum of 2 grams.

Intestinal Amebiasis

The daily dose is based on the child"s weight (50 milligrams per 2.2 pounds), up to a maximum of 2 grams, taken for 3 days.

Amebic Liver Abscess

The daily dose is based on the child"s weight (50 milligrams per 2.2 pounds), up to a maximum of 2 grams, taken for 3 to 5 days. Children who take Tinidazole for more than 3 days must be closely monitored.

Overdosage

There are no reported overdoses with Tinidazole. However, any medication taken in excess can have serious consequences. If you suspect an overdose, seek emergency treatment immediately.