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|Tindamax

TINIDAZOLE (Systemic)†

Some commonly used brand names are:

In the U.S.—

• Tindamax

† Not commercially available in Canada.

Category

• Antiprotozoal

Description

Tinidazole (ty-NI-da-zole) is used to treat infections caused by protozoa (tiny, one-celled animals). It works by killing the protozoa.

Tinidazole is available only with your doctor"s prescription, in the following dosage form:

• Oral
• Tablets (U.S.)

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For tinidazole, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to tinidazole or other nitroimidazole derivatives. Also tell your doctor and pharmacist if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Tinidazole has not been studied in pregnant women. However, studies in animals have shown that tinidazole may cause birth defects or other problems. Before taking this medicine, make sure your doctor knows if you are pregnant or if you become pregnant.

Tinidazole is not recommended during the first trimester of pregnancy.

Breast-feeding—Use is not recommended in nursing mothers since tinidazole passes into the breast milk and may cause unwanted effects in the baby. However, in some infections your doctor may want you to stop breast-feeding and take this medicine for a short time. During this time the breast milk should be squeezed out or sucked out with a breast pump and thrown away. One or two days after you finish taking this medicine, you may go back to breast-feeding.

Children—Tinidazole has been used in children three years of age and older for the treatment of giardiasis.

Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of tinidazole in the elderly with use in other age groups.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking tinidazole, it is especially important that your doctor and pharmacist know if you are taking any of the following:

• Anticoagulants (blood thinners)—Tinidazole may increase the effects of these medicines and possibly increase the risk of severe bleeding.

• Disulfiram (e.g., Antabuse)—Tell your doctor if you have taken disulfiram in the two weeks before starting tinidazole.
• Lithium —Patients taking lithium with tinidazole may have an increased chance of getting lithium side effects.

Other medical problems—The presence of other medical problems may affect the use of tinidazole. Make sure you tell your doctor if you have any other medical problems, especially:

• Blood disease or a history of blood disease—Tinidazole may make this condition worse.

• Central nervous system (CNS) disease, including epilepsy—Tinidazole may increase the chance of seizures (convulsions) or other CNS side effects.

• Liver disease, severe—Patients with severe liver disease may have an increase in side effects.
• Oral thrush or vaginal yeast infection—Tinidazole may make yeast infections worse.

Proper Use of This Medicine

If this medicine upsets your stomach, it may be taken with meals or a snack. If stomach upset (nausea, vomiting, stomach pain, or diarrhea) continues, check with your doctor.

To help clear up your infection completely, keep taking this medicine for the full time of treatment , even if you begin to feel better after a few days. If you stop taking this medicine too soon, your symptoms may return.

In some kinds of infections, this medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times, day and night . For example, if you are to take one dose a day, the doses should be spaced about 24 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your health care professional.

Some types of infections are treated with one dose of tinidazole.

Dosing—The dose of tinidazole will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of tinidazole. If your dose is different, do not change it unless your doctor tells you to do so.

The number of tablets that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking tinidazole

• For oral dosage form (tablets):
  • For amebiasis, intestinal infections:
    • Adults—2 grams per day for three days.
    • Children—50 milligrams per kilogram of body weight per day (up to to 2 grams per day) for three days.
  • For amebiasis, liver access:
    • Adults—2 grams per day for 3 to 5 days.
    • Children—50 milligrams per kilogram of body weight per day (up to to 2 grams per day) for 3 to 5 days.
  • For giardiasis infections:
    • Adults—2 grams per day for just one day.
    • Children—50 milligrams per kilogram of body weight per day (up to to 2 grams per day) for just one day.
  • For trichomoniasis infections:
    • Adults— 2 grams given once as a single dose.
    • Children—Use and dose must be determined by your doctor.

Missed dose—If you miss a dose of this medicine, take it as soon as possible. However, if you do not remember the missed dose until the next day, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage—To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store this medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

Drinking alcoholic beverages while taking this medicine may cause stomach pain, nausea, vomiting, headache, or flushing or redness of the face. Other alcohol-containing preparations (for example, elixirs, cough syrups, tonics) may also cause problems. These problems may last for at least 3 days after you stop taking tinidazole. Also, this medicine may cause alcoholic beverages to taste different. Therefore, you should not drink alcoholic beverages or take other alcohol-containing preparations while you are taking this medicine and for at least 3 days after stopping it .

If you are taking this medicine for trichomoniasis (an infection of the sex organs in males and females), your doctor may want to treat your sexual partner at the same time you are being treated, even if he or she has no symptoms. Also, it may be desirable to use a condom (prophylactic) during intercourse. These measures will help keep you from getting the infection back again from your partner. If you have any questions about this, check with your doctor.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Developed: 08/24/2004

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