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Thiothixene

Generic name: Thiothixene
Brand names: Navane

Why is Thiothixene prescribed?

Thiothixene is used in the treatment of schizophrenia (a disruption of thought and the understanding of reality). Researchers theorize that antipsychotic medications such as Thiothixene work by lowering levels of dopamine, a neurotransmitter (or chemical messenger) in the brain. Excessive levels of dopamine are believed to be related to psychotic behavior.

Most important fact about Thiothixene

Thiothixene may cause tardive dyskinesia--a condition marked by involuntary muscle spasms and twitches in the face and body. This condition can be permanent and appears to be most common among the elderly, especially women. Ask your doctor for information about this possible risk.

How should you take Thiothixene?

Thiothixene may be taken in liquid or capsule form. In liquid form, a dropper is supplied.

--If you miss a dose...

Take it as soon as you remember. If it is within 2 hours of your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once.

--Storage instructions...

Store at room temperature away from heat, light, and moisture. Keep the liquid form from freezing.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Thiothixene.

More common side effects may include:
Agitation, blood disorders, blurred vision, drowsiness, dry mouth, exaggerated reflexes, fainting, high blood pressure, insomnia, light-headedness, low blood pressure, Parkinson"s--like movements, profuse sweating, rapid or irregular heartbeat, rash, sensitivity to sunlight, skin color changes

Why should Thiothixene not be prescribed?

Do not give Thiothixene to comatose individuals. Do not take Thiothixene if you are known to be hypersensitive to it. Also, you should not be using Thiothixene if the activity of your central nervous system is slowed down for any reason--for example, by a sleeping medication, if you have had circulatory system collapse, or if you have an abnormal bone marrow or blood condition.

Special warnings about Thiothixene

Thiothixene may hide symptoms of brain tumor and intestinal obstruction. Your doctor will prescribe Thiothixene cautiously if you have or have ever had a brain tumor, breast cancer, convulsive disorders, the eye condition called glaucoma, intestinal blockage, or heart disease; or if you are exposed to extreme heat or are recovering from alcohol addiction.

This drug may impair your ability to drive a car or operate potentially dangerous machinery. Do not participate in any activities that require full alertness if you are unsure of your ability.

Possible food and drug interactions when taking Thiothixene

If Thiothixene is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Thiothixene with the following:

Antihistamines such as Benadryl
Barbiturates such as phenobarbital
Drugs that contain atropine, such as Donnatal

Extreme drowsiness and other potentially serious effects can result if Thiothixene is combined with alcohol or other central nervous system depressants such as painkillers, narcotics, or sleeping medications.

Special information if you are pregnant or breastfeeding

If you are pregnant or plan to become pregnant, inform your doctor immediately; pregnant women should use Thiothixene only if clearly needed. Consult your doctor if you are breastfeeding; he or she may have you stop while you are taking Thiothixene.

Recommended dosage

Dosages of Thiothixene are tailored to the individual. Usually treatment begins with a small dose, which is increased if needed.

ADULTS

For Milder Conditions

The usual starting dosage is a daily total of 6 milligrams, divided into doses of 2 milligrams and taken 3 times a day. Your doctor may increase the dose to a total of 15 milligrams a day.

For More Severe Conditions

The usual starting dosage is a daily total of 10 milligrams, taken in 2 doses of 5 milligrams each. Your doctor may increase this dose to a total of 60 milligrams a day.

Taking more than 60 milligrams a day rarely increases the benefits of Thiothixene.

Some people are able to take Thiothixene once a day. Check with your doctor to see whether you can follow this schedule.

CHILDREN

Thiothixene is not recommended for children younger than 12 years old.

OLDER ADULTS

In general, older adults are prescribed dosages of Thiothixene in the lower ranges. Because older adults may develop low blood pressure while taking Thiothixene, their doctors will monitor them closely. Older adults (especially women) may be more susceptible to such side effects as involuntary muscle spasms and twitches in the face and body. Check with your doctor for more information about these potential risks.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical help immediately.

Symptoms of Thiothixene overdose may include:
Central nervous system depression, coma, difficulty swallowing, dizziness, drowsiness, head tilted to the side, low blood pressure, muscle twitching, rigid muscles, salivation, tremors, walking disturbances, weakness

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