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Mellaril, Mellaril-S, |thioridazine Thioridazine

thioridazine

Generic Name: thioridazine (oral) (thye oh RIH da zeen)
Brand Names: Mellaril, Mellaril-S

What is thioridazine?

Thioridazine is in a class of drugs called phenothiazines. It works by changing the actions of chemicals in the brain.

Thioridazine is used to treat psychotic disorders, such as schizophrenia. Thioridazine is generally reserved for people who do not respond to other drugs or who cannot take other drugs due to side effects.

Thioridazine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about thioridazine?

Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.

What should I discuss with my healthcare provider before taking thioridazine?

Before taking thioridazine, tell your doctor if you have

• a bone marrow disease,

• glaucoma,

• seizures,

• Parkinson"s disease,

• an enlarged prostate or difficulty urinating,

• liver disease, or
• kidney disease.

You may not be able to take thioridazine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

How should I take thioridazine?

Take thioridazine exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Your doctor may want to monitor your heartbeats and obtain a blood sample before starting and periodically during treatment with thioridazine.

Thioridazine can be taken with or without food.

To ensure that you get a correct dose, measure the liquid forms of thioridazine with a dropper or a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

The liquid concentrate can be mixed with 2 to 4 ounces of water or a suitable juice. Each dose should be mixed just prior to taking.

Do not let the liquid concentrate touch your skin or clothes.

Throw away any discolored liquid.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Symptoms of a thioridazine overdose include uncontrollable movements, agitation, seizures, severe dizziness or fainting, coma, very deep sleep, irregular heartbeats, and high or low body temperature.

What should I avoid while taking thioridazine?

Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.

Thioridazine side effects

• an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

• uncontrollable movements of the mouth, tongue, cheeks, jaw, arms, or legs;

• fever;

• muscle rigidity;

• muscle spasms of the face or neck;

• sweating;

• irregular pulse;

• fast or irregular heartbeats.

• severe restlessness or tremor;

• severe drowsiness;

• blurred vision;

• dizziness or fainting; or

• a rash.

Other, less serious side effects may be more likely to occur. Continue to take thioridazine and talk to your doctor if you experience

• dry mouth, stuffy nose;

• constipation;

• mild restlessness, drowsiness, or tremor;

• decreased sex drive;

• increased appetite;

• difficult urination or dark urine; or

• menstrual irregularities or swollen breasts.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect thioridazine?

Thioridazine may interact with other drugs that cause drowsiness, including alcohol, antidepressants, antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if thioridazine is taken with alcohol or any of these medications. Talk to your doctor before taking thioridazine in combination with alcohol or any other medicines.

Thioridazine also interacts with many medications other than the ones listed here. Before taking thioridazine, tell your doctor about all other medicines you are taking. During treatment, do not start taking any new drug or herbal product without first talking to your doctor.

Where can I get more information?

• Your pharmacist has additional information about thioridazine written for health professionals that you may read.

What does my medication look like?

Thioridazine is available with a prescription under the brand name Mellaril. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Mellaril 10 mg--round, chartreuse, coated tablets

• Mellaril 15 mg--round, pink, coated tablets

• Mellaril 25--round, light-tan, coated tablets

• Mellaril 50 mg--round, white, coated tablets

• Mellaril 100 mg--round, light-green, coated tablets

• Mellaril 150 mg--round, yellow, coated tablets

• Mellaril 200 mg--round, pink, coated tablets

• Mellaril Concentrate 30 mg/1 mL--clear/straw-yellow liquid with strawberry odor

• Mellaril Concentrate 100 mg/1 mL--clear/straw-yellow liquid with strawberry odor

• Mellaril Suspension 25 mg/5 mL--off-white liquid with a buttermint taste and a peppermint odor

• Mellaril Suspension 100 mg/5 mL--off-white liquid with a buttermint taste and a peppermint odor

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.