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Thioplex, |Thioplex

Thioplex

Generic Name: thiotepa (thigh oh TEH pa)
Brand Names: Thioplex

What is thiotepa?

Thiotepa is a cancer (antineoplastic) medication. Thiotepa interferes with the growth of cancer cells and slows their growth and spread in the body.

Thiotepa is used in the treatment of cancers of the breast, ovary, bladder, and others.

Thiotepa may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about thiotepa?

Thiotepa should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Serious side effects have been reported with the use of thiotepa including: allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); severe heart damage with prolonged use; decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; fever or chills; or signs of infection); severe nausea, vomiting, diarrhea, and loss of appetite; and others. Talk to your doctor about the possible side effects from treatment with thiotepa.

What should I discuss with my healthcare provider before using thiotepa?

• kidney disease;
• liver disease; or

• poor bone marrow function.

The use of thiotepa may be dangerous if you have any of the conditions listed above.

How should I use thiotepa?

Thiotepa should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Your doctor will determine the correct amount and frequency of treatment with thiotepa depending upon the type of cancer being treated and other factors. Talk to your doctor if you have any questions or concerns regarding the treatment schedule.

Your doctor will probably want you to have regularly scheduled blood tests and other medical evaluations during treatment with thiotepa to monitor progress and side effects.

Skin accidentally exposed to thiotepa should be rinsed thoroughly with soap and warm water.

Your healthcare provider will store thiotepa as directed by the manufacturer. If you are storing thiotepa at home, follow the directions provided by your healthcare provider.

What happens if I miss a dose?

Contact your doctor if you miss a dose of thiotepa.

What happens if I overdose?

Symptoms of a thiotepa overdose tend to be similar to side effects caused by the medication, although often more severe.

What should I avoid while using thiotepa?

Thiotepa can lower the activity of your immune system making you susceptible to infections. Avoid contact with people who have colds, the flu, or other contagious illnesses and do not receive vaccines that contain live strains of a virus (e.g., live oral polio vaccine) during treatment with thiotepa. In addition, avoid contact with individuals who have recently been vaccinated with a live vaccine. There is a chance that the virus can be passed on to you.

Skin accidentally exposed to thiotepa should be rinsed thoroughly with soap and warm water.

Thiotepa side effects

If you experience any of the following serious side effects from thiotepa, seek emergency medical attention or contact your doctor immediately:

• an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

• decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection);

• tissue or vein reactions near the site of administration;

• liver damage (abdominal pain, yellowing of the skin or eyes);

• severe nausea, vomiting, or loss of appetite;

• fever, chills, or other signs of infection; or

• painful or difficult urination.

Other, less serious side effects may be more likely to occur. Continue taking thiotepa and talk to your doctor if you experience:

• fatigue or weakness;

• mild to moderate nausea, vomiting, or loss of appetite;

• redness or inflammation of the eyes;

• dizziness, headache, or blurred vision;

• temporary hair loss;

• a loss of skin coloration; or

• decreased menstruation in women and decreased sperm production in men.

Other side effects have also been reported. Discuss with your doctor any side effect that occurs during treatment with thiotepa.

What other drugs will affect thiotepa?

Drugs other than those listed here may also interact with thiotepa. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including herbal products, during treatment with thiotepa.

Where can I get more information?

• Your healthcare provider may have additional information about thiotepa that you may read.

What does my medication look like?

Thiotepa is available with a prescription under the brand name Thioplex. Other brand or generic formulations may also be available. Ask your healthcare provider or pharmacist any questions you have about this medication, especially if it is new to you.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.