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|Teniposide

Teniposide

Teniposide is used for:

Treating certain types of leukemia. Teniposide is used in combination with other medicines.

Teniposide is an antineoplastic. It works by damaging the tumor cell"s DNA, resulting in tumor cell death.

Do NOT use Teniposide if:

• you are allergic to any ingredient in Teniposide
• you are taking disulfiram, insulin, or sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Teniposide :

Some medical conditions may interact with Teniposide . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have Down syndrome

Some MEDICINES MAY INTERACT with Teniposide . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Barbiturates (eg, phenobarbital), cimetidine, or enprostil because the actions and side effects of Teniposide may be increased
• Acetaminophen, acitretin, amprenavir, barbiturates (eg, phenobarbital), CNS depressants (eg, lorazepam), insulin, monoamine oxidase (MAO) inhibitors (eg, phenelzine), nitrates (eg, nitroglycerin), phenformin/metformin, sodium oxybate (GHB), sulfonylureas (eg, glyburide), or vinca alkaloids (eg, vincristine) because the actions and side effects of these medicines may be increased
• Cephalosporins (eg, cefazolin), disulfiram, fluorouracil, furazolidone, or metronidazole because an acute alcohol intolerance reaction may occur
• Hydantoins (eg, phenytoin) or sulfonylureas (eg, glyburide) because the effectiveness of these medicines may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Teniposide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Teniposide :

Use Teniposide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Teniposide is usually administered as an injection at your doctor"s office, hospital, or clinic. If you are using Teniposide at home, carefully follow the injection procedures taught to you by your health care provider.
• If Teniposide contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
• Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
• If you miss a dose of Teniposide , contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Teniposide .

Important safety information:

• If nausea or vomiting occurs, ask you doctor or pharmacist for ways to lessen these effects.
• Teniposide may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Teniposide . Using Teniposide alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Teniposide may lower your body"s ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rash, or chills.
• Teniposide may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
• Avoid vaccinations with live virus vaccines (eg, measles, mumps, oral polio) while you are taking Teniposide . Vaccinations may be less effective.
• LAB TESTS, including complete blood cell counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
• Use Teniposide with caution in the ELDERLY because they may be more sensitive to its effects.
• Use Teniposide with extreme caution in NEWBORNS. Safety and effectiveness in this age group have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Teniposide has been shown to cause harm to the fetus. If you become pregnant, discuss with your doctor the benefits and risks of using Teniposide during pregnancy. It is unknown if Teniposide is excreted in breast milk. Do not breast-feed while taking Teniposide .

Possible side effects of Teniposide :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; hair loss; inflammation of the mucous membranes; nausea; rash; vomiting.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bleeding; chills; fever; flushing; pain, redness, or swelling at the injection site; sore throat or cough; sores on the mouth or lips; unusual bruising or bleeding; unusual tiredness.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org/findyour.htm), or emergency room immediately.

Store Teniposide in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Keep Teniposide , as well as needles and syringes, out of the reach of children and away from pets.

General information:

• If you have any questions about Teniposide , please talk with your doctor, pharmacist, or other health care provider.
• Teniposide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Teniposide . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.