Taxotere

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Taxotere, |Taxotere

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Taxotere

Generic Name: docetaxel (doe se TAX el)
Brand Names: Taxotere

What is docetaxel?

Docetaxel is a cancer medicine that slows the growth and spreading of cancer cells in the body.

Docetaxel is used to treat breast cancer, lung cancer, prostate cancer, stomach cancer, and head/neck cancer.

Docetaxel may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about docetaxel?

Do not use this medication without your doctor"s consent if you are pregnant. It could cause harm to the unborn baby. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment. Before being treated with docetaxel, tell your doctor if you have ever been treated with cisplatin (Platinol), or if you have liver disease, congestive heart failure, fluid retention, swelling problems, or if you have ever had an allergic reaction to docetaxel.

Docetaxel can be harmful if it gets on your skin during an IV infusion. If this happens, wash the skin thoroughly with soap and warm water.

Some people receiving a docetaxel injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, light-headed, warm, or itchy, or if you have chest tightness or trouble breathing during the injection.

Docetaxel can lower the blood cells that help your body fight infections. This can make it easier for you to get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Your liver function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.

Avoid contact with people who have colds, the flu, or other contagious illnesses. Contact your doctor immediately if you develop signs of infection, especially fever.

There are many other drugs that can interact with docetaxel. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

What should I discuss with my healthcare provider before using docetaxel?

Before being treated with docetaxel, tell your doctor if you have ever been treated with cisplatin (Platinol), or if you have:
  • liver disease;
  • congestive heart failure;

  • fluid retention or swelling problems; or

  • if you have ever had an allergic reaction to docetaxel.

If you have any of these conditions, you may not be able to receive docetaxel, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category D. This medication can cause harm to an unborn baby and should not be given to a woman who is pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. It is not known whether docetaxel passes into breast milk or if it could harm a nursing baby. Do not receive docetaxel without telling your doctor if you are breast-feeding a baby.

Adults older than 65 may be more sensitive to the side effects of docetaxel.

How is docetaxel used?

Docetaxel is given as an injection through a needle placed into a vein. You will receive this medicine in a clinic or hospital setting. Docetaxel must be given slowly through an IV and it may take up to an hour to complete your dose.

Your doctor may prescribe a steroid medicine for you to take for a few days before your injection. This will help prevent swelling or an allergic reaction to docetaxel. Do not miss any doses of the steroid.

Docetaxel must be given slowly through an IV and it may take up to an hour to complete your dose.

Docetaxel can be harmful if it gets on your skin during an IV infusion. If this happens, wash the skin thoroughly with soap and warm water.

Docetaxel is usually given once every 3 weeks, and you may receive other cancer medicines at the same time. Your doctor will determine a treatment schedule for you based on the type of cancer being treated and other factors.

Docetaxel can lower the blood cells that help your body fight infections. This can make it easier for you to get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Your liver function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of docetaxel or the steroid medicine.

What happens if I overdose?

Seek emergency medical attention if you think you have received too much of this medicine.

Symptoms of a docetaxel overdose may include fever, chills, body aches, flu symptoms, numbness, burning, pain, or tingly feeling, or white patches or sores inside your mouth or on your lips.

What should I avoid while using docetaxel?

Avoid getting a flu shot or vaccine while you are being treated with docetaxel. Vaccines may not work as well or could make you sick while you are using docetaxel.

Avoid contact with people who have colds, the flu, or other contagious illnesses. Contact your doctor immediately if you develop signs of infection, especially fever.

Avoid allowing this medicine to get on your skin during an IV infusion. If this does happen, wash the skin thoroughly with soap and warm water.

Docetaxel side effects

Some people receiving a docetaxel injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, light-headed, warm, or itchy, or if you have chest tightness or trouble breathing during the injection.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
  • easy bruising or bleeding, unusual weakness;

  • feeling light-headed, fainting;

  • fever, chills, body aches, flu symptoms;

  • severe diarrhea;

  • skin changes or bruising where the IV was placed;

  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • feeling short of breath, even with mild exertion;

  • swelling of your ankles or feet, weight gain;

  • a red, blistering, peeling skin rash; or

  • numbness, burning, pain, or tingly feeling.

Other, less serious side effects may be more likely to occur, such as:

  • feeling weak or tired;

  • white patches or sores inside your mouth or on your lips;

  • mild nausea, vomiting, diarrhea, constipation, or loss of appetite;

  • watery eyes;

  • changes in menstrual periods;

  • temporary hair loss; or

  • fingernail or toenail changes.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect docetaxel?

Do not receive "live" vaccines during treatment with docetaxel. Administration of a live vaccine may be dangerous during treatment with docetaxel.

There are many other drugs that can interact with docetaxel. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist has more information about docetaxel written for health professionals that you may read.

What does my medication look like?

Docetaxel is available with a prescription under the brand name Taxotere. Other brand or generic formulations may also be available. Ask your healthcare provider or pharmacist any questions you have about this medication, especially if it is new to you.

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 2.02. Revision Date: 11/13/06 11:53:56 AM.



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