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|Talc, Sterile Powder |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Talc, Sterile PowderPronouncation: (TALK)Class: Antineoplastic agent Trade Names: Trade Names: Mechanism of ActionPharmacologyInduces an inflammatory reaction, which promotes adherence of the visceral and parietal pleura, obliterating the pleural space and preventing reaccumulation of pleural fluid. Indications and UsageDecrease or prevent recurrence of malignant pleural effusions. ContraindicationsStandard considerations. Dosage and AdministrationAdultsIntrapleural Powder 5 g dissolved in 50 to 100 mL sodium chloride injection is recommended. Intrapleural Aerosol Single 4 to 8 g dose delivered from spray canister (1 to 2 cans), which delivers talc at a rate of 0.4 g/sec. General Advice
Storage/StabilityStore aerosol at controlled room temperature (59° to 86°F). Avoid freezing. Protect against sunlight. Do not expose to temperature greater than 120°F or canister may rupture. Contents under pressure. Do not puncture or incinerate canister. Store powder at controlled room temperature (64° to 77°F). Protect against sunlight. Drug InteractionsNone well documented. Laboratory Test InteractionsNone well documented. Adverse ReactionsCardiovascularTachycardia; MI; hypotension; hypovolemia; asystolic arrest. RespiratoryHypoxemia; dyspnea; unilateral pulmonary edema; pneumonia; acute respiratory distress syndrome; bronchopleural fistula; hemoptysis; pulmonary emboli. MiscellaneousFever; empyema; pain; infection at site of thoracostomy or thoracoscopy; localized bleeding; subcutaneous emphysema. PrecautionsPregnancyCategory B . ChildrenSafety and efficacy not established. Curable diseasesBecause talc has no antineoplastic activity, it should not be used alone for potentially curable malignancies where systemic therapy is appropriate. Future proceduresSclerosis of the pleural space may preclude subsequent diagnostic procedures of the pleura on the treated side. Pulmonary complicationsAcute pneumonitis and acute respiratory distress syndrome may occur. Patient Information
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