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Stalevo 100, Stalevo 150, Stalevo 50, |Stalevo 150

Stalevo 150

Generic Name: carbidopa, entacapone, and levodopa (car bih DOE pa, en ta CAH pone, lee voe DOE pa )
Brand Names: Stalevo 100, Stalevo 150, Stalevo 50

What is carbidopa, entacapone, and levodopa?

Carbidopa, entacapone, and levodopa are medications used to treat Parkinson"s disease. Parkinson"s disease is believed to be related to low levels of a chemical called dopamine (DOE pa meen) in the brain. Levodopa is turned into dopamine in the body. Carbidopa and entacapone are used with levodopa to prevent the breakdown (metabolism) of levodopa in the body.

Carbidopa, entacapone, and levodopa are used together to treat the stiffness, tremors, spasms, and poor muscle control associated with Parkinson"s disease.

Carbidopa, entacapone, and levodopa may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about carbidopa, entacapone, and levodopa?

What should I discuss with my healthcare provider before taking carbidopa, entacapone, and levodopa?

• narrow-angle glaucoma (angle closure glaucoma);

• current or past history of malignant melanoma (a type of skin cancer); or

• taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the past 14 days.

Before taking carbidopa, entacapone, and levodopa, tell your doctor if you have:

• heart disease, including high blood pressure, hardening of the arteries, a previous heart attack, or an irregular heartbeat;

• respiratory disease, including asthma and chronic obstructive pulmonary disease (COPD) (e.g., emphysema, chronic bronchitis);

• liver disease;
• kidney disease;

• a history of bile duct obstruction;

• an endocrine (hormonal) disease;

• a stomach or intestinal ulcer;

• wide-angle glaucoma; or

• depression or mental health problems.

You may not be able to take carbidopa, entacapone, and levodopa, or you may need a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

How should I take carbidopa, entacapone, and levodopa?

Take carbidopa, entacapone, and levodopa exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

It is important to take carbidopa, entacapone, and levodopa regularly to get the most benefit.

Your doctor may want you to have blood tests or other medical evaluations during treatment with carbidopa, entacapone, and levodopa to monitor progress and side effects.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and only take the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Symptoms of a carbidopa, entacapone, and levodopa overdose may include muscle spasms or weakness, spasms of the eyelid, nausea, vomiting, diarrhea, irregular heartbeat, confusion, agitation, hallucinations, and unconsciousness.

What should I avoid while taking carbidopa, entacapone, and levodopa?

Do not take iron products or vitamin or mineral supplements that contain iron without first talking to your doctor. Iron may reduce the effectiveness of carbidopa, entacapone, and levodopa.

Carbidopa, entacapone, and levodopa side effects

• an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

• uncontrolled movements of a part of the body;

• fever;

• seizures;

• severe nausea, vomiting, or diarrhea;

• an irregular heartbeat or fluttering in the chest;

• hallucinations;

• unusual changes in mood or behavior; or

• depression or suicidal thoughts.

Other, less serious side effects may be more likely to occur. Continue to take carbidopa, entacapone, and levodopa and talk to your doctor if you experience

• mild nausea, vomiting, or decreased appetite;

• constipation, dry mouth, or blurred vision;

• hand tremor;

• muscle twitches;

• dizziness or drowsiness;

• insomnia, confusion, or nightmares;

• agitation or anxiety;

• darkening of urine, sweat, or saliva (may cause discoloration of clothing); or

• fatigue.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect carbidopa, entacapone, and levodopa?

Before taking carbidopa, entacapone, and levodopa, tell your doctor if you are taking any of the following medicines:

• antacids;

• iron supplements or vitamin supplements containing iron;

• metoclopramide (Reglan);

• isoniazid (Nydrazid);

• phenytoin (Dilantin);

• probenecid (Benemid);

• cholestyramine (Questran, Prevalite, Locholest);

• erythromycin (Ery-Tab, E-Mycin, Eryc, PCE Dispertab, E.E.S., and others);

• rifampin (Rimactane, Rifadin);

• ampicillin (Principen, Totacillin, Omnipen, and others);

• a medicine to treat high blood pressure (hypertension);

• a tricyclic antidepressant such as amitriptyline (Elavil), doxepin (Sinequan), nortriptyline (Pamelor), desipramine (Norpramin), amoxapine (Asendin), and others; or

• a medicine used to treat psychiatric conditions (and nausea and vomiting) such as chlorpromazine (Thorazine), prochlorperazine (Compazine), promethazine (Phenergan), fluphenazine (Prolixin), mesoridazine (Serentil), thioridazine (Mellaril), trifluoperazine (Stelazine), risperidone (Risperdal), or haloperidol (Haldol).

You may not be able to take carbidopa, entacapone, and levodopa, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Levodopa may interfere with urine tests for sugar and ketones. If you have diabetes and notice changes in urine test results, talk to your doctor before making any changes to medications for diabetes.

Drugs other than those listed here may also interact with carbidopa, entacapone, and levodopa. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

• Your pharmacist has more information about carbidopa, entacapone, and levodopa written for health professionals that you may read.

What does my medication look like?

Carbidopa, entacapone, and levodopa is available with a prescription under the brand name Stalevo. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Stalevo 50-brownish- or greyish-red, round tablets

• Stalevo 100-brownish- or greyish-red, oval tablets

• Stalevo 150-brownish- or greyish-red, enlongated-ellipse shaped tablets

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.