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|SD Deprenyl

SELEGILINE (Systemic)

Some commonly used brand names are:

In the U.S.—

• Carbex
• Eldepryl

In Canada—

• Apo-Selegiline
• Eldepryl
• Gen-Selegiline
• Novo-Selegiline
• Nu-Selegiline
• SD Deprenyl
• Selegiline-5

Generic name product may be available in the U.S.

Other commonly used names are deprenil and deprenyl .

Category

• Antidyskinetic

Description

Selegiline (seh-LEDGE-ah-leen) is used in combination with levodopa or levodopa and carbidopa combination to treat Parkinson"s disease, sometimes called shaking palsy or paralysis agitans. This medicine works to increase and extend the effects of levodopa, and may help to slow the progress of Parkinson"s disease.

Selegiline is available only with your doctor"s prescription, in the following dosage form:

• Oral
• Capsules (U.S.)
• Tablets (U.S. and Canada)

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For selegiline, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to selegiline. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Selegiline has not been studied in pregnant women. However, this medicine has not been shown to cause birth defects or other problems in animal studies.

Breast-feeding—It is not known whether selegiline passes into the breast milk.

Children—Studies on this medicine have been done only in adult patients and there is no specific information about its use in children. Therefore, be sure to discuss with your doctor the use of this medicine in children.

Older adults—In studies done to date that included elderly people, selegiline did not cause different side effects or problems in older people than it did in younger adults.

Other medicines—Although certain medicines should not be used together at all, in other cases 2 different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking selegiline, it is especially important that your health care professional know if you are taking any of the following:

• Antidepressants, tricyclic (amitriptyline [e.g., Elavil], amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Norpramin], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil], nortriptyline [e.g., Pamelor], protriptyline [e.g., Vivactil], trimipramine [e.g., Surmontil]) or
• Fluoxetine (e.g., Prozac) or
• Fluvoxamine (e.g., Luvox) or
• Meperidine (e.g., Demerol) or
• Nefazodone (e.g., Serzone) or
• Paroxetine (e.g., Paxil) or
• Sertraline (e.g., Zoloft) or
• Venlafaxine (e.g., Effexor)—Using these medicines together may increase the chance of serious side effects

Other medical problems—The presence of other medical problems may affect the use of selegiline. Make sure you tell your doctor if you have any other medical problems, especially:

• Stomach ulcer (history of)—Selegiline may make the condition worse

Proper Use of This Medicine

Take this medicine only as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Dosing—The dose of selegiline will be different for different patients. Your doctor will determine the proper dose of selegiline for you. Follow your doctor"s orders or the directions on the label .

For the treatment of Parkinson"s disease, the usual dose of selegiline is 5 mg two times a day, taken with breakfast and lunch. Some patients may need less than this.

Missed dose—If you miss a dose of this medicine, take it as soon as possible. However, if you do not remember the missed dose until late afternoon or evening, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage—To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

When selegiline is taken at doses of 10 mg or less per day for the treatment of Parkinson"s disease, there are no restrictions on food or beverages you eat or drink. However, the chance exists that dangerous reactions, such as sudden high blood pressure, may occur if doses higher than those used for Parkinson"s disease are taken with certain foods, beverages, or other medicines. These foods, beverages, and medicines include:

• Foods that have a high tyramine content (most common in foods that are aged or fermented to increase their flavor), such as cheeses; fava or broad bean pods; yeast or meat extracts; smoked or pickled meat, poultry, or fish; fermented sausage (bologna, pepperoni, salami, summer sausage) or other fermented meat; sauerkraut; or any overripe fruit. If a list of these foods and beverages is not given to you, ask your health care professional to provide one.
• Alcoholic beverages or alcohol-free or reduced-alcohol beer and wine.
• Large amounts of caffeine-containing food or beverages such as coffee, tea, cola, or chocolate.
• Any other medicine unless approved or prescribed by your doctor. This especially includes nonprescription (over-the-counter [OTC]) medicine, such as that for colds (including nose drops or sprays), cough, asthma, hay fever, and appetite control; “keep awake” products; or products that make you sleepy.

Also, for at least 2 weeks after you stop taking this medicine, these foods, beverages, and other medicines may continue to react with selegiline if it was taken in doses higher than those usually used for Parkinson"s disease.

Check with your doctor or hospital emergency room immediately if severe headache, stiff neck, chest pains, fast heartbeat, or nausea and vomiting occur while you are taking this medicine. These may be symptoms of a serious side effect that should have a doctor"s attention.

Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help. If the problem continues or gets worse, check with your doctor.

Selegiline may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

Side Effects of This Medicine

When you start taking selegiline in addition to levodopa or carbidopa and levodopa combination, you may experience an increase in side effects. If this occurs, your doctor may gradually reduce the amount of levodopa or carbidopa and levodopa combination you take.

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Revised: 01/21/1998

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