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Generic Name: Pilocarpine Tablets (pye-loe-KAR-peen)
Brand Name: Salagen

Salagen is used for:

Treating dry mouth associated with radiation treatment for cancer or Sjogren syndrome. It may also be used for other conditions as determined by your doctor.

Salagen is a cholinergic agent. It works by increasing the secretion of saliva from the salivary glands, which helps to relieve dry mouth.

Do NOT use Salagen if:

  • you are allergic to any ingredient in Salagen
  • you have glaucoma, a severe eye infection, eye inflammation, or uncontrolled asthma

Contact your doctor or health care provider right away if any of these apply to you.

Before using Salagen :

Some medical conditions may interact with Salagen . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, plan to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a detached retina or an eye infection
  • if you have heart disease, asthma, chronic bronchitis, chronic obstructive pulmonary disease, kidney or liver disease, gallstones, or gall bladder problems
  • if you have a psychiatric disorder

Some MEDICINES MAY INTERACT with Salagen . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Parasympathomimetic agents (eg, bethanecol) because the side effects of Salagen may be increased
  • Beta-blockers (eg atenolol) because the risk of side effects, such as abnormal heartbeat, may occur
  • Anticholinergic agents (eg, atropine, ipratropium) because the effectiveness may be decreased by Salagen

This may not be a complete list of all interactions that may occur. Ask your health care provider if Salagen may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Salagen :

Use Salagen as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Salagen may be taken with or without food.
  • Drinking extra fluids while you are taking Salagen is recommended. Check with your doctor for instructions.
  • If you miss a dose of Salagen , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Salagen .

Important safety information:

  • Salagen may cause blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Salagen . Using Salagen alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • It may take 12 weeks for Salagen to work.
  • Salagen is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Salagen during pregnancy. It is unknown if Salagen is excreted in breast milk. Do not breast-feed while taking Salagen .

Possible side effects of Salagen :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Chills; dizziness; flushing; frequent urination; nausea; runny nose; sweating; vision changes (eg, blurred vision); weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abdominal pain; breathing problems; change in heart rate; confusion; excessive sweating; excessive tears; headache; shaking; vomiting.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Symptoms may include abnormal heartbeat; blood pressure changes; confusion; diarrhea; difficulty breathing; headache; tremors; vision changes; vomiting.

Proper storage of Salagen :

Store Salagen at room temperature, up to 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Keep Salagen out of the reach of children and away from pets.

General information:

  • If you have any questions about Salagen , please talk with your doctor, pharmacist, or other health care provider.
  • Salagen is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Salagen . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition
Copyright © 2006 Wolters Kluwer Health, Inc.

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