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Endodan, Percodan, Percodan-Demi, Roxiprin, |Roxiprin

Roxiprin

Generic Name: aspirin and oxycodone (AS pir in and ox i KOE done)
Brand Names: Endodan, Percodan, Percodan-Demi, Roxiprin

What is aspirin and oxycodone?

Oxycodone (related to codeine) is in a class of drugs called narcotic analgesics. It relieves pain.

Aspirin is a less potent pain reliever, as well as an anti-inflammatory and a fever reducer. Aspirin increases the effects of oxycodone.

The combination, aspirin and oxycodone, is used to treat moderate-to-severe pain.

Aspirin and oxycodone may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about aspirin and oxycodone?

Also avoid sleeping pills, tranquilizers, sedatives, and antihistamines except under the supervision of your doctor. These medicines also may cause dangerous sedation.

Never take more aspirin and oxycodone than is prescribed for you. If your pain is not being adequately treated, talk to your doctor.

Avoid other over-the-counter and prescription products that contain aspirin. Too much aspirin could be dangerous. Talk to your doctor or pharmacist before taking any over-the-counter preparations.

Who should not take aspirin and oxycodone?

Oxycodone is habit forming and should be used only under close supervision if you have an alcohol or drug addiction.

Before taking this medication, tell your doctor if you

• drink more than three alcoholic drinks per day;

• have kidney disease;
• have liver disease;

• have asthma;

• have urinary retention;

• have an enlarged prostate;

• have hypothyroidism;

• have a stomach ulcer;

• have a coagulation (bleeding) disorder;

• have congestive heart failure, high blood pressure, or another heart disease;

• have fluid retention;

• have seizures or epilepsy;

• have gallbladder disease;

• have a head injury; or

• have Addison"s disease.

You may not be able to take aspirin and oxycodone, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

How should I take aspirin and oxycodone?

Take aspirin and oxycodone exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Never take more of this medication than is prescribed for you. Too much aspirin and oxycodone could be very harmful.

Do not stop taking aspirin and oxycodone suddenly if you have been taking it continuously for more than 5 to 7 days. Stopping suddenly could cause withdrawal symptoms and make you feel uncomfortable. Your doctor may want to gradually reduce your dose.

Do not share this medication with anyone else.

Do not take this drug if it begins to smell strongly of vinegar. This smell means that the aspirin is beginning to break down.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Do not take a double dose of this medication. Wait the prescribed amount of time before taking your next dose.

What happens if I overdose?

Symptoms of an aspirin and oxycodone overdose include slow breathing, seizures, dizziness, weakness, loss of consciousness, coma, confusion, tiredness, cold and clammy skin, small pupils, ringing in your ears, nausea, vomiting, and sweating.

What should I avoid while taking aspirin and oxycodone?

Also avoid sleeping pills, tranquilizers, sedatives, and antihistamines except under the supervision of your doctor. These medicines also may cause dangerous sedation.

Aspirin and oxycodone side effects

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• slow, weak breathing;

• seizures;

• cold, clammy skin;

• severe weakness or dizziness;

• unconsciousness;

• yellowing of the skin or eyes;

• unusual fatigue;

• bleeding or bruising; or

• black, bloody, or tarry stools or blood in the urine or vomit.

Other, less serious side effects may be more likely to occur. Continue to take oxycodone and talk to your doctor if you experience

• constipation;

• dry mouth, nausea, vomiting, or decreased appetite;

• dizziness, tiredness, or lightheadedness;

• muscle twitches;

• sweating;

• itching;

• decreased urination;

• decreased sex drive; or

• ringing in the ears.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect aspirin and oxycodone?

Do not take aspirin and oxycodone if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. Dangerous side effects could result.

Oxycodone may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), other pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine unless your doctor approves.

Before taking aspirin and oxycodone, tell your doctor if you are taking any of the following medicines:

• an oral anticoagulant such as warfarin (Coumadin);

• a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin, others), ketoprofen (Orudis, Orudis KT, Oruvail), naproxen (Naprosyn, Anaprox, Aleve), and others;

• other salicylates (forms of aspirin) such as choline salicylate and/or magnesium salicylate (Magan, Doan"s, Bayer Select Backache Pain Formula, Mobidin, Arthropan, Trilisate, Tricosal) and salsalate (Disalcid);

• a steroid such as prednisone (Deltasone), methylprednisolone (Medrol), prednisolone (Prelone, Pediapred, others), and others;

• probenecid (Benemid);

• sulfinpyrazone (Anturane);

• an angiotensin-converting-enzyme (ACE) inhibitor such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), and others;
• a beta-blocker such as acebutolol (Sectral), propranolol (Inderal), atenolol (Tenormin), metoprolol (Lopressor), and others;

• an oral diabetes medication such as glipizide (Glucotrol) or glyburide (Micronase, Diabeta);

• lithium (Lithobid, Eskalith, others); or

• cyclosporine (Sandimmune, Neoral).

You may not be able to take aspirin and oxycodone, or you may require a dosage adjustment or special monitoring during your treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with aspirin and oxycodone. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

• Your pharmacist has additional information about aspirin and oxycodone written for health professionals that you may read.

What does my medication look like?

Aspirin and oxycodone is available with a prescription under the brand names Percodan, Percodan-Demi, Roxiprin, and Endodan. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Aspirin/oxycodone strengths are as follows:

• Percodan 325 mg/5 mg--yellow, round, scored tablets

• Percodan-Demi 325 mg/2.5 mg--white, scored tablets

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.