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|Rimexolone |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home RimexolonePronouncation: (rih-MEX-oh-lone)Class: Corticosteroid Trade Names: Mechanism of ActionPharmacologySuppresses inflammatory response to stimuli of a mechanical, chemical, or immunological origin. PharmacokineticsAbsorptionOphthalmic preparation is absorbed systemically, reaching serum levels ranging from 80 to 470 pg/mL (mean level 130 pg/mL) after hourly waking doses for 1 wk. MetabolismUndergoes extensive metabolism with metabolites less active than parent drug. Indications and UsageTreatment of postoperative inflammation following ocular surgery; treatment of anterior uveitis. ContraindicationsAcute purulent untreated infections, which may be masked or enhanced by steroid administration; epithelial herpes simplex keratitis (dendritic keratitis); fungal diseases of the eye; mycobacterial infection of the eye; vaccinia; varicella; viral diseases of the cornea and conjunctiva; hypersensitivity to any ingredient. Dosage and AdministrationPostoperative Inflammation1 to 2 drops into conjunctival sac of affected eye qid, beginning 24 hr after surgery and continuing throughout the first 2 wk of postoperative period. Anterior Uveitis1 to 2 drops into conjunctival sac of affected eye every hour during waking hours for first week; 1 drop q 2 hr during waking hours of second week; taper until uveitis resolves. Storage/StabilityStore ophthalmic suspension in refrigerator (36° to 46°F) or at controlled room temperature (68° to 77°F). Protect from freezing. Drug InteractionsNone well documented. Laboratory Test InteractionsNone well documented. Adverse ReactionsCardiovascularHypotension (less than 2%). CNSHeadache (less than 2%). EENTBlurred vision, discharge, discomfort, foreign body sensation, hyperemia, increased IOP, ocular pain, pruritus (which may be associated with optic nerve damage), visual acuity, and field defects, perforation of globe where there is thinning of cornea or sclera, posterior subcapsular cataract formation, secondary ocular infection (eg, herpes simplex) (1% to 5%); pharyngitis, rhinitis (less than 2%). GITaste perversion (less than 2%). PrecautionsPregnancyCategory C . LactationUndetermined. ChildrenSafety and efficacy not established. Fungal infectionsFungal infections of cornea are prone to develop coincidentally with long-term local steroid application. IOPProlonged use may result in ocular hypertension or glaucoma. Monitor IOP if product is used for 10 days or longer. Patient Information
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