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|Rifabutin

Rifabutin

Rifabutin is used for:

Preventing mycobacterium avium complex (MAC) disease in patients with advanced HIV infection.

Rifabutin is an antibacterial. It works by preventing or slowing the growth of certain bacteria.

Do NOT use Rifabutin if:

• you are allergic to any ingredient in Rifabutin or to any other rifamycins (eg, rifampin)
• you have active tuberculosis (TB) or kidney problems
• you are taking an HIV protease inhibitor (eg, ritonavir) or voriconazole

Contact your doctor or health care provider right away if any of these apply to you.

Before using Rifabutin :

Some medical conditions may interact with Rifabutin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have kidney problems

Some MEDICINES MAY INTERACT with Rifabutin . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Many prescription and nonprescription medicines used for infections (eg, voriconazole), blood thinners, high cholesterol, birth control, heart problems, HIV infection (eg, ritonavir), mental or mood problems, seizures, or diabetes, and herbs found in multivitamin products, herbal teas, and dietary supplements (eg, garlic, St. John"s wort) may interact with this medicine and increase the risk of side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Rifabutin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Rifabutin :

Use Rifabutin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Rifabutin may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Do not wear contact lenses while you are using Rifabutin . Sterilize contact lenses according to manufacturer"s directions and check with your doctor before using them.
• To clear up your infection completely, continue using Rifabutin for the full course of treatment even if you feel better in a few days.
• If you miss a dose of Rifabutin , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Rifabutin .

Important safety information:

• Rifabutin may discolor the urine, stools, saliva, sweat, tears, and skin (usually a brown-orange color). This is normal and not a cause for concern. It may also permanently stain soft contact lenses. If possible, do not wear contact lenses while you are taking Rifabutin .
• Rifabutin is effective only against certain bacteria. It is not effective for treating viral infections (eg, the common cold).
• It is important to use Rifabutin for the full course of treatment. Failure to do so may decrease the effectiveness of Rifabutin and increase the risk that the bacteria will no longer be sensitive to Rifabutin and will not be able to be treated by this or certain other antibiotics in the future.
• Rifabutin may lower your body"s ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rash, or chills.
• Rifabutin may decrease the effectiveness of your birth control pill. To prevent pregnancy, be sure to use an additional form of birth control (eg, condoms) while using Rifabutin .
• LAB TESTS, including blood cell counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
• Rifabutin is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.
• PREGNANCY and BREAST-FEEDING: It is unknown if Rifabutin can cause harm to the fetus. If you become pregnant while taking Rifabutin , discuss with your doctor the benefits and risks of using Rifabutin during pregnancy. It is unknown if Rifabutin is excreted in breast milk. Do not breast-feed while taking Rifabutin .

Possible side effects of Rifabutin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in taste; diarrhea; discolored urine; headache; indigestion; loss of appetite; nausea; sleeplessness; stomach pain; vomiting.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; eye pain, swelling, or sensitivity to light; flu-like symptoms (eg, fever, chills, sore throat); unusual bruising or bleeding; unusual muscle pain or weakness; vision changes or decreased vision; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Store Rifabutin at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Rifabutin out of the reach of children and away from pets.

General information:

• If you have any questions about Rifabutin , please talk with your doctor, pharmacist, or other health care provider.
• Rifabutin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Rifabutin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.