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|Riboflavin |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Riboflavin( Vitamin B 2 ) Pronouncation: (RYE-boh-FLAY-vin)Class: Water-soluble vitamin Trade Names: Mechanism of ActionPharmacologyIs converted in body to coenzyme necessary in oxidation reduction. Also necessary in maintaining integrity of RBCs. PharmacokineticsAbsorptionAbsorbed from duodenum. DistributionRiboflavin and metabolites distributed into all body tissues and breast milk. Small amount stored in liver, spleen, kidneys, and heart. Protein binding is 60% (metabolites FAD and FMN). MetabolismHepatic. EliminationEliminated in urine (excreted mostly as metabolites), small amount in bile, feces, and sweat. T 1/2 is 66 to 84 min (oral or IM). Indications and UsagePrevention and treatment of riboflavin deficiency. ContraindicationsNone well documented. Dosage and AdministrationSupplementAdults PO 1.4 to 1.8 mg (men), 1.2 to 1.3 mg (women), 1.6 to 1.8 mg (pregnant or lactating women). ChildrenPO 0.8 to 1.2 mg/day. Treatment of DeficiencyAdults PO 5 to 10 mg/day. ChildrenPO 2 to 10 mg/day. Drug InteractionsNone well documented. Laboratory Test InteractionsLarge doses produce bright-yellow urine, which may contain fluorescent substances and interfere with urinalysis based on spectrometry or color reactions. Adverse ReactionsGenitourinaryYellow-orange discoloration of urine. PrecautionsPregnancyCategory A ( Category C in doses that exceed the RDA). LactationExcreted in breast milk. DeficiencyRiboflavin deficiency rarely occurs alone; often associated with deficiency of other B vitamins and protein. Patient Information
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