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Reglan, |Reglan

Reglan

Generic Name: metoclopramide (meh toe KLOE pra mide)
Brand Names: Reglan

What is metoclopramide?

Metoclopramide increases the rate at which the stomach and intestines move during digestion. It also increases the rate at which the stomach empties into the intestines and increases the strength of the lower esophageal sphincter (the muscle between the stomach and esophagus).

Metoclopramide is used to treat diabetic gastric stasis (slow movement of the stomach), which causes symptoms such as nausea, vomiting, heartburn, decreased appetite, and prolonged fullness after eating. It is also used to treat gastric reflux or heartburn (the regurgitation of stomach acid into the esophagus), prevention of postoperative nausea and vomiting, prevention of nausea and vomiting associated with cancer chemotherapy, facilitation of small bowel intubation, and to facilitate x-ray examination of the stomach and intestines.

Metoclopramide may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about metoclopramide?

Call your doctor immediately if you experience uncontrollable movements or muscle spasms of your arms, legs, lips, jaw, tongue, face, or other body part; or if you experience unexplained anxiety, agitation, jitteriness, shortness of breath, or insomnia. These symptoms could be early signs of a serious side effect requiring immediate treatment.

What should I discuss with my healthcare provider before taking metoclopramide?

• bleeding, an injury, or an obstruction in your stomach;

• pheochromocytoma; or

• epilepsy or another seizure disorder.

These conditions make it dangerous to use metoclopramide.

Before taking this medication, tell your doctor if you have

• kidney disease;

• a history of depression;

• Parkinson"s disease;

• diabetes;

• high blood pressure; or

• recently had stomach surgery.

You may not be able to take metoclopramide, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

How should I take metoclopramide?

Take metoclopramide exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

To ensure that you get a correct dose, measure the liquid form of metoclopramide with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Metoclopramide is available as both a syrup and a concentrated solution. Although the dose remains the same, the amount of liquid needed to make a dose is different. Follow your doctor"s instructions.

Metoclopramide is usually taken four times a day, 30 minutes before meals and at bedtime. Follow your doctor"s instructions.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Symptoms of a metoclopramide overdose include drowsiness; confusion; uncontrollable movements of the arms, legs, face, or tongue; muscle spasm of the neck; tremor; irritability; and agitation.

What should I avoid while taking metoclopramide?

Metoclopramide side effects

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• uncontrollable movements or spasms of your arms, legs, lips, jaw, tongue, face, or other body part;

• anxiety, agitation, jitteriness, difficulty breathing, or insomnia;

• depression;

• yellowing of the skin or eyes;

• changes in vision;

• an irregular heartbeat; or

• seizures or hallucinations.

Other, less serious side effects may be more likely to occur. Continue to take metoclopramide and talk to your doctor if you experience

• nausea or diarrhea;

• dizziness, drowsiness, or headache;

• confusion;

• fluid retention (swelling of hands or legs, bloating);

• breast tenderness or swelling;

• changes in your menstrual cycle; or

• increased frequency of urination.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect metoclopramide?

Tell your doctor if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil) in the last 14 days. Metoclopramide must be used very cautiously if you are taking any of these medicines.

Before taking metoclopramide, tell your doctor if you are taking any of the following medicines:

• digoxin (Lanoxin, Lanoxicaps);

• cyclosporine (Sandimmune, Neoral);

• tetracycline (Sumycin, others);

• levodopa (Larodopa, Dopar, Sinemet);

• insulin;

• a narcotic pain reliever such as morphine (MS Contin, MSIR, others), codeine, hydrocodone (Vicodin, Hycodan), oxycodone (Percocet, Percodan, Tylox, OxyContin), oxymorphone (Numorphan), and others; or

• clidinium (Quarzan), dicyclomine (Bentyl), hyoscyamine (Levsin, Cystospaz, Anaspaz), belladonna (Donnatal), or propantheline (Pro-Banthine).

You may not be able to take metoclopramide, or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.

Metoclopramide may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine unless your doctor approves.

Drugs other than those listed here may also interact with metoclopramide. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

• Your pharmacist has more information about metoclopramide written for health professionals that you may read.

What does my medication look like?

Metoclopramide is available with a prescription under the brand name Reglan. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Reglan 5 mg--green, elliptical tablets

• Reglan 10 mg--white, capsule-shaped tablets

• Reglan Syrup 5 mg per5 mL (1 teaspoon)

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.