drug-information.ru

|Pyridostigmine Bromide

Drugs search, click the first letter of a drug name:

| A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home

Pyridostigmine Bromide

Pronouncation: (pihr-id-oh-STIG-meen BROE-mide)
Class: Anticholinesterase muscle stimulant

Trade Names:
Mestinon
- Tablets 60 mg
- Tablets, extended-release 180 mg
- Syrup 60 mg/5 mL
- Injection 5 mg/mL

Mechanism of Action

Pharmacology

Facilitates myoneural junction impulse transmission by inhibiting acetylcholine destruction by cholinesterase.

Pharmacokinetics

Elimination

Primarily excreted unchanged by the kidney.

Indications and Usage

Treatment of myasthenia gravis; reversal agent or antagonist to nondepolarizing muscle relaxants such as curariform drugs and gallamine triethiodide (IV only).

Contraindications

Mechanical intestinal or urinary obstruction; hypersensitivity to anticholinesterase agents.

Dosage and Administration

Adults

PO Individualize dosage to meet the needs of the patients.

Syrup/Conventional tablet

Average dose is ten 5 mL tsp (60 mg/5 mL) daily or ten 60 mg tablets spaced to provide max relief when max strength is needed (range is usually 1 to 25 tablets or tsp/day).

Extended-release tablets

One to three 180 mg tablets, qd or bid with at least 6 hr between doses.

IV To supplement oral dosage preoperatively and postoperatively during labor and postpartum, during myasthenic crisis, or when oral therapy is impractical, give approximately 1/30 the oral dose, either IM or very slow IV.

Neonates

IV Neonates of myasthenic mothers may have transient difficulty in swallowing, sucking, and breathing. Injectable pyridostigmine may be indicated (by symptoms and use of the edrophonium test) until syrup can be taken. Dosage requirements range from 0.05 to 0.15 mg/kg IM.

Reversal of Nondepolarizing Muscle Relaxants
Injection

Give atropine sulfate (0.6 to 1.2 mg) IV immediately prior to pyridostigmine to minimize side effects. Pyridostigmine 10 or 20 mg IV is usually sufficient. Full recovery usually occurs in no more than 15 min but at least 30 min may be required.

General Advice

Administer without regard to meals. Administer with food if GI upset occurs.
Do not chew or crush extended-release tablet. Instruct patient to swallow tablet(s) whole.
Store at controlled room temperature (59° to 86°F).

Drug Interactions

Atropine

May mask signs of overdosage, leading to inadvertent induction of cholinergic crisis.

Corticosteroids

The therapeutic effects of pyridostigmine may be antagonized.

Succinylcholine

Neuromuscular blockade produced by succinylcholine may be prolonged or antagonized.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Dermatologic

Skin rash.

EENT

Miosis.

GI

Nausea; vomiting; diarrhea; abdominal cramps; increased peristalsis; increased salivation.

Musculoskeletal

Muscle cramps and fasciculation; weakness.

Respiratory

Increased bronchial secretions.

Miscellaneous

Increased sweating.

Precautions

Pregnancy

Category C .

Lactation

Excreted in breast milk.

Renal Function

Lower doses may be required in patients with renal disease.

Bronchial asthma

Use with caution.

Cardiac dysrhythmias (IV only)

Use with caution. Transient bradycardia may occur and be relieved by atropine sulfate.

Cholinergic crisis

Observe patients closely for cholinergic reactions, particularly if the IV route is used. May be difficult to distinguish from myasthenic crisis. Differentiation is important because increasing the dose of pyridostigmine or other drugs of this class may have grave consequences in patients in cholinergic crisis.

Overdosage

Symptoms

Cholinergic crisis, characterized by increasing muscle weakness (including respiratory paralysis and death).

Patient Information

Explain name, dose, action, and potential side effects of drug.
Advise patient that dose and frequency of administration may be adjusted to achieve max benefit.
Advise patient to take exactly as prescribed and not to change the dose or stop taking unless advised by health care provider.
Advise patient to take prescribed dose without regard to meals but to take with food if upset stomach occurs.
Instruct patient to contact health care provider immediately if any of the following occur: worsening muscle weakness, difficulty breathing, slow heart rate, dizziness, fainting.
Advise women to notify health care provider if pregnant, planning to become pregnant, or breastfeeding.
Instruct patient not to take any prescription or OTC medications or dietary supplements unless advised by health care provider.
Advise patient that follow-up visits will be required to monitor therapy and to keep appointments.

Where can I get more information about Pyridostigmine Bromide ? We recommend to use www.Drugs.com

Typical mistypes for Pyridostigmine Bromide
oyridostigmine bromide, lyridostigmine bromide, -yridostigmine bromide, 0yridostigmine bromide, ptridostigmine bromide, pgridostigmine bromide, phridostigmine bromide, puridostigmine bromide, p7ridostigmine bromide, p6ridostigmine bromide, pyeidostigmine bromide, pydidostigmine bromide, pyfidostigmine bromide, pytidostigmine bromide, py5idostigmine bromide, py4idostigmine bromide, pyrudostigmine bromide, pyrjdostigmine bromide, pyrkdostigmine bromide, pyrodostigmine bromide, pyr9dostigmine bromide, pyr8dostigmine bromide, pyrisostigmine bromide, pyrixostigmine bromide, pyricostigmine bromide, pyrifostigmine bromide, pyrirostigmine bromide, pyrieostigmine bromide, pyridistigmine bromide, pyridkstigmine bromide, pyridlstigmine bromide, pyridpstigmine bromide, pyrid0stigmine bromide, pyrid9stigmine bromide, pyridoatigmine bromide, pyridoztigmine bromide, pyridoxtigmine bromide, pyridodtigmine bromide, pyridoetigmine bromide, pyridowtigmine bromide, pyridosrigmine bromide, pyridosfigmine bromide, pyridosgigmine bromide, pyridosyigmine bromide, pyridos6igmine bromide, pyridos5igmine bromide, pyridostugmine bromide, pyridostjgmine bromide, pyridostkgmine bromide, pyridostogmine bromide, pyridost9gmine bromide, pyridost8gmine bromide, pyridostifmine bromide, pyridostivmine bromide, pyridostibmine bromide, pyridostihmine bromide, pyridostiymine bromide, pyridostitmine bromide, pyridostignine bromide, pyridostigkine bromide, pyridostigjine bromide, pyridostigmune bromide, pyridostigmjne bromide, pyridostigmkne bromide, pyridostigmone bromide, pyridostigm9ne bromide, pyridostigm8ne bromide, pyridostigmibe bromide, pyridostigmime bromide, pyridostigmije bromide, pyridostigmihe bromide, pyridostigminw bromide, pyridostigmins bromide, pyridostigmind bromide, pyridostigminr bromide, pyridostigmin4 bromide, pyridostigmin3 bromide, pyridostigmine vromide, pyridostigmine nromide, pyridostigmine hromide, pyridostigmine gromide, pyridostigmine beomide, pyridostigmine bdomide, pyridostigmine bfomide, pyridostigmine btomide, pyridostigmine b5omide, pyridostigmine b4omide, pyridostigmine brimide, pyridostigmine brkmide, pyridostigmine brlmide, pyridostigmine brpmide, pyridostigmine br0mide, pyridostigmine br9mide, pyridostigmine bronide, pyridostigmine brokide, pyridostigmine brojide, pyridostigmine bromude, pyridostigmine bromjde, pyridostigmine bromkde, pyridostigmine bromode, pyridostigmine brom9de, pyridostigmine brom8de, pyridostigmine bromise, pyridostigmine bromixe, pyridostigmine bromice, pyridostigmine bromife, pyridostigmine bromire, pyridostigmine bromiee, pyridostigmine bromidw, pyridostigmine bromids, pyridostigmine bromidd, pyridostigmine bromidr, pyridostigmine bromid4, pyridostigmine bromid3, yridostigmine bromide, pridostigmine bromide, pyidostigmine bromide, pyrdostigmine bromide, pyriostigmine bromide, pyridstigmine bromide, pyridotigmine bromide, pyridosigmine bromide, pyridostgmine bromide, pyridostimine bromide, pyridostigine bromide, pyridostigmne bromide, pyridostigmie bromide, pyridostigmin bromide, pyridostigminebromide, pyridostigmine romide, pyridostigmine bomide, pyridostigmine brmide, pyridostigmine broide, pyridostigmine bromde, pyridostigmine bromie, pyridostigmine bromid, ypridostigmine bromide, pryidostigmine bromide, pyirdostigmine bromide, pyrdiostigmine bromide, pyriodstigmine bromide, pyridsotigmine bromide, pyridotsigmine bromide, pyridositgmine bromide, pyridostgimine bromide, pyridostimgine bromide, pyridostigimne bromide, pyridostigmnie bromide, pyridostigmien bromide, pyridostigmin ebromide, pyridostigmineb romide, pyridostigmine rbomide, pyridostigmine bormide, pyridostigmine brmoide, pyridostigmine broimde, pyridostigmine bromdie, pyridostigmine bromied, ppyridostigmine bromide, pyyridostigmine bromide, pyrridostigmine bromide, pyriidostigmine bromide, pyriddostigmine bromide, pyridoostigmine bromide, pyridosstigmine bromide, pyridosttigmine bromide, pyridostiigmine bromide, pyridostiggmine bromide, pyridostigmmine bromide, pyridostigmiine bromide, pyridostigminne bromide, pyridostigminee bromide, pyridostigmine bromide, pyridostigmine bbromide, pyridostigmine brromide, pyridostigmine broomide, pyridostigmine brommide, pyridostigmine bromiide, pyridostigmine bromidde, pyridostigmine bromidee, etc.