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|pyrazinamide Pyrazinamide

pyrazinamide

Generic Name: pyrazinamide (peer a ZIN a mide)
Brand Names:

What is pyrazinamide?

Pyrazinamide is an antibiotic. The exact way that pyrazinamide works is unknown.

Pyrazinamide is used to treat tuberculosis (TB).

Pyrazinamide may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about pyrazinamide?

Call your doctor immediately if you experience a fever, loss of appetite, nausea and vomiting, painful or swollen joints, yellowing of your skin or eyes, or darkening of your urine.

Who should not take pyrazinamide?

Before taking pyrazinamide, tell your doctor if you have

• ever had an allergic reaction to pyrazinamide,

• liver disease,

• gout,

• kidney disease, or

• diabetes mellitus.

You may not be able to take pyrazinamide, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

How should I take pyrazinamide?

Take pyrazinamide exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Pyrazinamide is usually combined with one or more other tuberculosis medicines.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication.

What happens if I overdose?

Symptoms of an pyrazinamide overdose are not well known. Liver damage has been detected.

What should I avoid while taking pyrazinamide?

There are no restrictions on foods, beverages, or activities during treatment with pyrazinamide unless your doctor directs otherwise.

Pyrazinamide side effects

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• a fever;

• unusual weakness or fatigue;

• nausea, vomiting, or loss of appetite;

• yellow skin or eyes;

• dark urine;

• difficult or painful urination;

• painful or swollen joints;

• worsening gout; or

• a rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect pyrazinamide?

Pyrazinamide may decrease the effects of allopurinol (Zyloprim). A dosage adjustment may be necessary if you take pyrazinamide during treatment with allopurinol.

Pyrazinamide may affect the Acetest and Ketostix urine tests for ketones. This reaction can cause a pink-brown color to appear.

Drugs other than those listed here may also interact with pyrazinamide. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

• Your pharmacist has additional information about pyrazinamide written for health professionals that you may read.

What does my medication look like?

Pyrazinamide is available generically with a prescription. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Pyrazinamide 500 mg--round, white tablets

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.