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Darvon, Darvon-N, PP-Cap, |propoxyphene Propoxyphene

propoxyphene

Generic Name: propoxyphene (pro POX i feen)
Brand Names: Darvon, Darvon-N, PP-Cap

What is propoxyphene?

Propoxyphene is in a class of drugs called narcotic analgesics. It relieves pain.

Propoxyphene is used to treat moderate-to-severe pain.

Propoxyphene may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about propoxyphene?

Do not take propoxyphene if you suffer from depression or have suicidal thoughts.

Propoxyphene will cause drowsiness and fatigue. Avoid alcohol, sleeping pills, antihistamines, sedatives, and tranquilizers except under the supervision of your doctor. These may also make you drowsy.

Never take more propoxyphene than is prescribed for you. If your pain is not being adequately treated, talk to your doctor.

Who should not take propoxyphene?

Propoxyphene is habit forming and should only be used under close supervision if you have an alcohol or drug addiction.

Propoxyphene should not be taken if you suffer from depression or have suicidal thoughts.

Before taking this medication, tell your doctor if you have

• kidney disease;
• liver disease;

• asthma;

• urinary retention;

• an enlarged prostate;

• hypothyroidism;

• seizures or epilepsy;

• gallbladder disease;

• a head injury; or

• Addison"s disease.

You may not be able to take propoxyphene, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

How should I take propoxyphene?

Take propoxyphene exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Never take more of this medication than is prescribed for you. Too much propoxyphene could be very harmful. The maximum amount of propoxyphene that can be taken safely in one day is 390 mg (6 Darvon capsules). Do not exceed this amount.

Do not stop taking propoxyphene suddenly if you have been taking it continuously for more than 5 to 7 days. Stopping suddenly could cause withdrawal symptoms and make you feel uncomfortable. Your doctor may want to gradually reduce your dose.

Do not share this medication with anyone else.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Do not take a double dose of this medication. Wait the prescribed amount of time before taking your next dose.

What happens if I overdose?

Symptoms of a propoxyphene overdose include slow breathing, seizures, dizziness, weakness, loss of consciousness, coma, confusion, tiredness, cold and clammy skin, and small pupils.

What should I avoid while taking propoxyphene?

Also avoid sleeping pills, tranquilizers, sedatives, and antihistamines except under the supervision of your doctor. These medications also may cause dangerous sedation.

Propoxyphene side effects

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• slow, weak breathing;

• seizures;

• cold, clammy skin;

• unconsciousness; or

• severe weakness or dizziness.

Other, less serious side effects may be more likely to occur. Continue to take propoxyphene and talk to your doctor if you experience

• constipation;

• dry mouth, nausea, vomiting, or decreased appetite;

• dizziness, tiredness, or lightheadedness;

• muscle twitches;

• sweating;

• itching;

• decreased urination; or

• decreased sex drive.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect propoxyphene?

Propoxyphene may increase the effects of oral anticoagulants such as warfarin (Coumadin), which could lead to bleeding. It may also increase the effects of carbamazepine (Tegretol), which could lead to dangerous side effects. Before taking this medication, tell your doctor if you are taking either of these medications.

Do not take propoxyphene if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. Dangerous side effects could result.

The most serious interactions affecting propoxyphene are with those drugs that also cause sedation. The following drugs may lead to dangerous sedation if taken with propoxyphene:

• antihistamines such as brompheniramine (Dimetane, Bromfed, others), diphenhydramine (Benadryl, Nytol, Compoz, others), chlorpheniramine (Chlor-Trimeton, Teldrin, others), and others;

• tricyclic antidepressants, such as amitriptyline (Elavil) and doxepin (Sinequan), and serotonin reuptake inhibitors such as fluoxetine (Prozac), sertraline (Zoloft), and paroxetine (Paxil);
• other commonly used antidepressants, including amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), and protriptyline (Vivactil);

• anticholinergics such as belladonna (Donnatal), clidinium (Quarzan), dicyclomine (Bentyl, Antispas), hyoscyamine (Levsin, Anaspaz), ipratropium (Atrovent), propantheline (Pro-Banthine), and scopolamine (Transderm-Scop);

• phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Prolixin), thioridazine (Mellaril), and prochlorperazine (Compazine); and

• tranquilizers and sedatives such as phenobarbital (Solfoton, Luminal), amobarbital (Amytal), secobarbital (Seconal), alprazolam (Xanax), diazepam (Valium), lorazepam (Ativan), flurazepam (Dalmane), and temazepam (Restoril).

Do not take any of the drugs listed above without the approval of your doctor.

Drugs other than those listed here may also interact with propoxyphene. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

• Your pharmacist has additional information about propoxyphene written for health professionals that you may read.

What does my medication look like?

Propoxyphene is available with a prescription under the brand name Darvon. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Darvon 65 mg--opaque-pink, parabola-shaped capsules

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.