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|Prochlorperazine

Prochlorperazine

Prochlorperazine is used for:

Controlling severe nausea and vomiting and treating schizophrenia. It is also used for the short-term (4 weeks) treatment of generalized nonpsychotic anxiety. It may also be used to treat other conditions as determined by your doctor.

Prochlorperazine is a phenothiazine. It works by blocking a certain chemical (dopamine) in the brain.

Do NOT use Prochlorperazine if:

• you are allergic to any ingredient in Prochlorperazine or similar medicines
• you are taking large amounts of central nervous system depressants (eg, alcohol, barbiturates, narcotics)
• you are taking astemizole, cisapride, or terfenadine
• you have severe central nervous system depression

Contact your doctor or health care provider right away if any of these apply to you.

Before using Prochlorperazine :

Some medical conditions may interact with Prochlorperazine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of heart disease, central nervous system depression, blood problems, liver problems, low blood pressure, increased pressure in the eye, neuroleptic malignant syndrome, tardive dyskinesia, bone marrow problems, unusual muscle movements, Parkinson disease, a predisposition to glaucoma, Reye syndrome, prostate problems, or seizures, or you have alcoholism

Some MEDICINES MAY INTERACT with Prochlorperazine . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticholinergics (eg, diphenhydramine, oxybutynin, scopolamine) or lithium because the effectiveness of Prochlorperazine may be decreased
• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), anticholinergics (eg, diphenhydramine, oxybutynin, scopolamine), general anesthetics (eg, thiopental), haloperidol, methyldopa, or tricyclic antidepressants (eg, amitriptyline) because side effects, such as seizures, may be increased
• ACE inhibitors (eg, enalapril), anticholinergics (eg, diphenhydramine, oxybutynin, scopolamine), astemizole, cisapride, dofetilide, haloperidol, hydantoins (eg, phenytoin), methyldopa, metrizamide, naltrexone, polypeptide antibiotics (eg, actinomycin), serotonin receptor antagonist antiemetics (eg, ondansetron), terfenadine, tramadol, trazodone, or tricyclic antidepressants (eg, amitriptyline) because the actions and side effects of these medicines may be increased
• Bromocriptine, guanethidine, levodopa, or pergolide because the effectiveness of these medicines may be decreased
• Lithium because unexpected toxic effects may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Prochlorperazine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Prochlorperazine :

Use Prochlorperazine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• If you are using Prochlorperazine at home, carefully follow the injection procedures taught to you by your health care provider.
• If the medicine contains particles or is discolored, or if the vial/container is cracked or damaged in any way, do not use it.
• If you miss a dose of Prochlorperazine , contact your doctor for further instruction.

Ask your health care provider any questions you may have about how to use Prochlorperazine .

Important safety information:

• Prochlorperazine may cause drowsiness, dizziness, blurred vision, or lightheadedness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Prochlorperazine . Using Prochlorperazine alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
• Prochlorperazine may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.
• Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Prochlorperazine . Prochlorperazine will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Prochlorperazine .
• Prochlorperazine may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Prochlorperazine . Use a sunscreen or protective clothing if you must be outside for a prolonged period.
• Avoid exposure to extreme heat while taking Prochlorperazine .
• Patients who will be having spinal cord surgery should stop using Prochlorperazine at least 48 hours before surgery. Do not use Prochlorperazine for at least 24 hours after surgery and do not use it to control nausea and vomiting that has occurred before or after surgery.
• Neuroleptic malignant syndrome (NMS) is a potentially life-threatening syndrome associated with Prochlorperazine . Symptoms may include increased body heat; rigid muscles; altered mental abilities, including lack of response to your surroundings; irregular or fast heartbeat; or sweating. Contact your doctor at once if any of these symptoms occur.
• Use Prochlorperazine with caution in the ELDERLY because they may be more sensitive to its effects.
• Prochlorperazine is not recommended for use in CHILDREN who are having surgery, who are younger than 2 years of age, or who weigh less than 20 pounds. Safety and effectiveness in these groups have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Prochlorperazine during pregnancy. Prochlorperazine is excreted in breast milk. If you are or will be breast-feeding while you are using Prochlorperazine , check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Prochlorperazine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; chills; constipation; dizziness; drowsiness; dry mouth; jitteriness; nasal congestion; sleeplessness.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; altered mental abilities, including lack of response to your surroundings; changes in breasts; changes in menstrual period; changes in vision; difficulty swallowing; drooling; excessive sweating; fever; inability to move eyes; increased body heat; involuntary movements of tongue, face, mouth, or jaw (eg, protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements); irregular or fast heartbeat; mask-like face; muscle spasms of face, neck, or back; muscle stiffness; prolonged or painful erection; restlessness; rigid muscles; shuffling walk; sore throat; tension in legs; tremors; twitching or twisting movements; unusual eye movements; weakness of arms or legs; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include deep sleep or loss of consciousness; muscle spasms; restlessness; seizures; tremors; twitching.

Store Prochlorperazine between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Keep Prochlorperazine , as well as syringes and needles, out of the reach of children and away from pets.

General information:

• If you have any questions about Prochlorperazine , please talk with your doctor, pharmacist, or other health care provider.
• Prochlorperazine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Prochlorperazine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.