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|Probenecid

Probenecid

Probenecid is used for:

Treating high levels of uric acid in the blood caused by gout or gouty arthritis. It may be used to increase blood levels of certain antibiotics (eg, penicillin). It may also be used for other conditions as determined by your doctor.

Probenecid is a uricosuric agent. It works by increasing the excretion of uric acid from the body.

Do NOT use Probenecid if:

• you are allergic to any ingredient in Probenecid
• you have blood problems or kidney stones caused by uric acid
• the patient is a child younger than 2 years of age
• you are taking salicylates (eg, aspirin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Probenecid :

Some medical conditions may interact with Probenecid . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have liver or kidney problems, kidney stones, high levels of uric acid in the urine, stomach or intestinal problems (eg, ulcer, spastic colon), diabetes, or glucose-6 phosphate dehydrogenase deficiency
• if you are undergoing radiation therapy

Some MEDICINES MAY INTERACT with Probenecid . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Acidifying agents (eg, ammonium chloride), pyrazinamide, or salicylates (eg, aspirin) because effectiveness of Probenecid may be decreased
• Acetaminophen, beta lactam antibiotics (eg, imipenem), cephalosporins (eg, cephalexin), certain anesthesias (eg, ketamine, thiopental), ganciclovir, indomethacin, lorazepam, methotrexate, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, ketoprofen), penicillins (eg, amoxicillin), rifampin, sulfonamides (eg, sulfamethoxazole), sulfonylureas (eg, glipizide), theophyllines (eg, dyphylline), or zidovudine because their actions and side effects may be increased by Probenecid

This may not be a complete list of all interactions that may occur. Ask your health care provider if Probenecid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Probenecid :

Use Probenecid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Probenecid may be taken with or without food.
• You should not start taking Probenecid if you are currently having a gout attack. Wait until the gout attack stops to begin taking Probenecid unless directed otherwise by your doctor. If you are already taking Probenecid , you may continue to take it during a gout attack unless your doctor tells you otherwise.
• Drinking extra fluids while you are taking Probenecid is recommended. Check with your doctor for instructions.
• Follow the dietary plan given to you by your doctor or other health care professional.
• If you miss a dose of Probenecid , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Probenecid .

Important safety information:

• Probenecid may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Probenecid . Using Probenecid alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Probenecid .
• Diabetes patients - Probenecid may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.
• Probenecid may interfere with some lab tests (eg, blood or hemoglobin urine tests, theophylline levels). Make sure your doctor and lab personnel know you are using Probenecid .
• LAB TESTS, including tests for sugar in the urine, may be required to monitor your progress. Be sure to keep all doctor and lab appointments.
• Use of Probenecid is not recommended in CHILDREN younger than 2 years of age. Safety and effectiveness in this age group have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Probenecid , discuss with your doctor the benefits and risks of using Probenecid during pregnancy. Probenecid is excreted in breast milk. If you are or will be breast-feeding while you are using Probenecid , check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Probenecid :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; flushing; hair loss; headache; loss of appetite; nausea; sore gums; vomiting.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; chills; dark urine; decreased or increased urination; fever; lower back, lower stomach, genital, or inner thigh pain; persistent sore throat; severe or persistent nausea, vomiting, or stomach pain; unusual bleeding or bruising; unusual tiredness or weakness; worsening gout; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm ), or emergency room immediately. Symptoms may include severe or persistent nausea, stomach pain, or vomiting.

Store Probenecid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Probenecid out of the reach of children and away from pets.

General information:

• If you have any questions about Probenecid , please talk with your doctor, pharmacist, or other health care provider.
• Probenecid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is summary only. It does not contain all information about Probenecid . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.