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Prinzide, Zestoretic, |Prinzide

Prinzide

Generic Name: hydrochlorothiazide and lisinopril (hye droe klor oh THYE a zide and lyse IN oh pril)
Brand Names: Prinzide, Zestoretic

What is hydrochlorothiazide and lisinopril?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Lisinopril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme.

The combination of hydrochlorothiazide and lisinopril is used to treat hypertension (high blood pressure).

Hydrochlorothiazide and lisinopril may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about hydrochlorothiazide and lisinopril?

Before using this medication, tell your doctor if you have kidney disease (or if you are on dialysis), liver disease, congestive heart failure or a heart rhythm disorder, high cholesterol, asthma, allergies, gout, or diabetes.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor"s instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

What should I discuss with my doctor before taking hydrochlorothiazide and lisinopril?

• are unable to urinate; or

• if you have an allergy to sulfa drugs.

Before using hydrochlorothiazide and lisinopril, tell your doctor if you are allergic to any drugs, or if you have:

• kidney disease (or if you are on dialysis);
• liver disease;

• congestive heart failure or a heart rhythm disorder;

• high cholesterol;

• asthma or allergies;

• gout; or

• diabetes.

If you have any of these conditions, you may not be able to use hydrochlorothiazide and lisinopril, or you may need a dosage adjustment or special tests during treatment.

How should I take hydrochlorothiazide and lisinopril?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

You may take this medication with or without food.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. It is important that you not miss any scheduled visits to your doctor.

Vomiting, diarrhea, or heavy sweating can cause you to become dehydrated. This can lead to very low blood pressure, electrolyte disorders, or kidney failure while you are taking hydrochlorothiazide and lisinopril. Drink 6 to 8 full glasses of water daily while you are taking this medication.

To be sure this medication is helping your condition, your blood and blood pressure will need to be checked on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled visits to your doctor.

If you need to have any type of surgery, tell the surgeon ahead of time that you are taking hydrochlorothiazide and lisinopril. You may need to stop using the medicine for a short time.

Hydrochlorothiazide and lisinopril can interfere with the results of a thyroid test. Tell any doctor who treats you that you are using a thiazide diuretic.

If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

What should I avoid while taking hydrochlorothiazide and lisinopril?

Avoid using other medicines that make you light-headed (narcotic pain medication, muscle relaxers, and medicine for seizures). They can add to the side effects of hydrochlorothiazide and lisinopril.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor"s instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Hydrochlorothiazide and lisinopril side effects

• stomach pain with or without nausea or vomiting;

• dry mouth, increased thirst, drowsiness, restless feeling, confusion, nausea, vomiting, increased urination, muscle pain or weakness, fast or uneven heart rate, feeling light-headed, fainting, or seizure (convulsions);

• urinating less than usual, or not at all;

• fever, chills, body aches, flu symptoms;

• numbness or tingly feeling;

• a red, blistering, peeling skin rash; or

• nausea or stomach pain with low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Keep taking the medication and talk with your doctor if you have any of these less serious side effects:

• mild nausea, vomiting, or stomach pain;

• constipation or diarrhea;

• dizziness, drowsiness, headache;

• blurred vision;

• cough; or

• mild skin itching or rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect hydrochlorothiazide and lisinopril?

Before taking hydrochlorothiazide and lisinopril, tell your doctor if you are taking any of the following drugs:

• other blood pressure medications;

• cholestyramine (Prevalite, Questran) or colestipol (Colestid);

• digoxin (Lanoxin);

• lithium (Lithobid, Eskalith);

• insulin or diabetes medication you take by mouth;

• steroids (prednisone and others);

• aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene); or

• other diuretics (water pills) such as amiloride (Midamor), bumetanide (Bumex), chlorthalidone (Hygroton, Thalitone), ethacrynic acid (Edecrin), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril), indapamide (Lozol), metolazone (Mykrox, Zarxolyn), spironolactone (Aldactone), triamterene (Dyrenium, Maxzide, Dyazide), torsemide (Demadex).

If you are using any of these drugs, you may not be able to use hydrochlorothiazide and lisinopril or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect hydrochlorothiazide and lisinopril. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist has information about hydrochlorothiazide and lisinopril written for health professionals that you may read.

What does my medication look like?

Hydrochlorothiazide and lisinopril is available with a prescription under the brand names Prinzide and Zestoretic. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.