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Generic Name: Imipenem/Cilastatin Intravenous Injection (ih-mih-PEN-em/SIGH-lah-STAT-in)
Brand Name: Primaxin IV
Primaxin IV is used for:
Treating serious infections caused by certain bacteria.
Primaxin IV is a carbapenem antibiotic. It kills bacteria by blocking growth of the bacteria"s cell wall.
Do NOT use Primaxin IV if:
- you are allergic to any ingredient in Primaxin IV or any other carbapenem
- you are taking probenecid
- the patient is a child with a brain or nervous system infection, or weighs less than 66 lb (30 kg) and has kidney problems
Contact your doctor or health care provider right away if any of these apply to you.
Before using Primaxin IV :
Some medical conditions may interact with Primaxin IV . Tell your doctor or pharmacist if you have any medical conditions, especially
if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to a penicillin antibiotic (eg, amoxicillin)
or cephalosporin antibiotic (eg, cephalexin)
- if you have kidney problems, a history of seizures or central nervous system problems (eg, brain lesions), or you are in shock
- if you are on dialysis
Some MEDICINES MAY INTERACT with Primaxin IV . Tell your health care provider if you are taking any other medicines, especially any of the following:
- Ganciclovir because risk of seizures may be increased
- Probenecid because actions and side effects of Primaxin IV may be increased
- Valproic acid because effectiveness may be decreased by Primaxin IV
- Other medicines that may increase your risk of seizures (eg, tramadol)
because the risk of seizures may be further increased when combined with Primaxin IV . Ask your doctor or pharmacist if you have questions about whether any of your other medicines may increase your risk for seizures.
This may not be a complete list of all interactions that may occur. Ask your health care provider if Primaxin IV may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Primaxin IV :
Use Primaxin IV as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Primaxin IV is usually administered as an injection at your
doctor"s office, hospital, or clinic. If you are using Primaxin IV at home, carefully follow the injection procedures taught to you by your health care provider.
- If Primaxin IV contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
- To clear up your infection completely, continue using Primaxin IV for the full course of treatment even if you feel better in a few days.
- Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
- If you miss a dose of Primaxin IV , use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions
you may have about how to use Primaxin IV .
Important safety information:
- Primaxin IV may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Primaxin IV . Using Primaxin IV alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
- It is important to use Primaxin IV for the full course of treatment. Failure to do so may decrease the effectiveness of Primaxin IV and may increase the risk that the bacteria will no longer be sensitive to Primaxin IV and will not be able to be treated by this or certain other antibiotics in the future.
- Primaxin IV is effective only against bacteria. It is not effective for treating viral infections (eg, the common cold).
- If severe diarrhea, stomach pain/cramps, or bloody stools occur, contact your doctor immediately. This could be a
symptom of a serious side effect requiring immediate medical attention. Do not treat diarrhea without consulting your doctor.
- Long-term or repeated use of Primaxin IV may cause a second infection. Your doctor may want to change your medicine to treat the second infection. Contact your doctor if signs of a second infection occur.
- If severe diarrhea, stomach pain/cramps, or bloody stools occur, contact your doctor immediately. This could be a symptom of a serious side effect requiring immediate medical attention. Do not treat diarrhea without consulting your doctor.
- LAB TESTS, including kidney function, liver function, and blood counts, may be performed to monitor your progress. Be sure to keep all doctor and lab appointments.
- Use Primaxin IV with caution in the ELDERLY because they may be more sensitive to its effects.
- Use Primaxin IV with extreme caution in CHILDREN younger than 10 years of age who have diarrhea or a stomach
or bowel infection.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Primaxin IV during pregnancy. It is unknown if Primaxin IV is excreted in breast milk. If you are or will be breast-feeding while you are taking Primaxin IV , check with your doctor or pharmacist to discuss the risks to your baby.
Possible side effects of Primaxin IV :
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Mild diarrhea; nausea; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing;
tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; breathing problems; chest pain; dark urine; decreased urination; fast or irregular heartbeat; fever, chills, or sore throat; hearing loss; joint pain or tenderness;
mental or mood changes (eg, agitation, anxiety, confusion);
numbness or tingling of the skin; pain, swelling, or redness at the injection site; red, swollen, blistered, or peeling skin; seizures; severe diarrhea;
severe stomach cramps or pain; swelling of the hands or feet; tremors or abnormal muscle movements; shortness of breath; unusual bruising or bleeding; unusual tiredness or weakness; unusual vaginal odor or discharge; vein swelling or tenderness; white patches in the mouth; yellowing of the eyes or skin.
This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison
Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include seizures; slow breathing;
Proper storage of Primaxin IV :
Primaxin IV is usually handled and stored by a health care provider. If you are using Primaxin IV at home, store Primaxin IV as directed by your pharmacist or health care provider. Keep Primaxin IV out of the reach of children and away from pets.
- If you have any questions about Primaxin IV , please talk with your doctor, pharmacist, or other health care provider.
- Primaxin IV is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Primaxin IV . If you have
questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Issue Date: November 1, 2006
Database Edition 06.4.1.002
Copyright © 2006 Wolters Kluwer Health, Inc.
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