Primaquine Phosphate

|Primaquine Phosphate

Drugs search, click the first letter of a drug name:

| A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9  Home

Primaquine Phosphate

Pronouncation: (PRIM-uh-kween FOSS-fate)
Class: Antimalarial

Trade Names:
Available as generic only
- Tablets 26.3 mg (equiv. to 15 mg base)
- Powder no strength

Mechanism of Action


Disrupts metabolic processes of parasitic organism, eliminating tissue (exoerythrocytic) infection and preventing development of blood (erythrocytic) forms of parasite responsible for relapses of vivax malaria.



Rapid. Bioavailability is approximately 96%. T max is approximately 2 to 3 hr (primaquine), approximately 7 hr (metabolite carboxyprimaquine). C max is 50 to 66 ng/mL (15 mg); 104 ng/mL (30 mg).


Extensively distributed. Vd is 248 L. C max is 291 to 736 ng/mL (metabolite) and 432 to 1240 ng/mL (metabolite).


Rapidly converted to carboxyprimaquine. Undetermined if the main plasma metabolite has activity.


Urine (less than 2% of dose). T 1/2 is 5.8 hr (primaquine); 22 to 30 hr (metabolite carboxyprimaquine).

Indications and Usage

Radical cure or prevention of relapse in vivax malaria; after termination of chloroquine phosphate suppressive therapy in areas where vivax malaria is endemic.

Unlabeled Uses

With clindamycin, treatment of Pneumocystis carinii pneumonia associated with AIDS.


Concomitant administration of quinacrine and primaquine; acutely ill patient with systemic disease manifested by granulocytopenia (eg, rheumatoid arthritis, lupus erythematosus); concurrent administration of other potentially hemolytic or bone marrow depressant medications.

Dosage and Administration

Begin therapy during last 2 wk of or after course of suppression with chloroquine or comparable drug.


PO 26.3 mg (15 mg base) for 14 days.


PO 0.5 mg/kg/day (0.3 mg/kg/day of base) for 14 days (max, 15 mg/day of base).

General Advice

Administer without regard to meals. Administer with food if GI upset occurs.


Store at room temperature in tightly closed, light-resistant container.

Drug Interactions


May potentiate toxicity of antimalarial compounds that are structurally related to primaquine.

Laboratory Test Interactions

None well documented.

Adverse Reactions


Nausea; vomiting; epigastric distress; abdominal cramps.


Leukopenia; hemolytic anemia in G-6-PD deficiency; methemoglobinemia in NADH methemoglobin reductase deficiency.



Pregnancy category undetermined.


Undetermined. To avoid adverse effects in the infant, do not give to lactating women.

Hemolytic anemia

May occur in patients with following conditions: G-6-PD deficiency, NADH methemoglobin reductase deficiency; idiosyncratic reactions (leukopenia, methemoglobinemia; hemolytic anemia). Discontinue drug if marked darkening of urine or sudden decrease in hemoglobin or leukocyte count occurs.

Max dose

Hemolytic reactions may occur with doses of drug exceeding recommended dose.



Anemia, methemoglobinemia, leukopenia, acute abdominal cramps, vomiting, epigastric distress, CNS and cardiovascular disturbances, granulocytopenia, hemolytic anemia.

Patient Information

  • Tell patient that medicine may be taken with food if stomach upset (eg, nausea, vomiting, abdominal cramps) occurs, and advise patient to contact health care provider if upset persists.
  • Emphasize importance of compliance with drug regimen.
  • Advise patient to report marked darkening of urine to health care provider.

Where can I get more information about Primaquine Phosphate ? We recommend to use

Typical mistypes for Primaquine Phosphate
orimaquine phosphate, lrimaquine phosphate, -rimaquine phosphate, 0rimaquine phosphate, peimaquine phosphate, pdimaquine phosphate, pfimaquine phosphate, ptimaquine phosphate, p5imaquine phosphate, p4imaquine phosphate, prumaquine phosphate, prjmaquine phosphate, prkmaquine phosphate, promaquine phosphate, pr9maquine phosphate, pr8maquine phosphate, prinaquine phosphate, prikaquine phosphate, prijaquine phosphate, primzquine phosphate, primsquine phosphate, primwquine phosphate, primqquine phosphate, prima1uine phosphate, prima2uine phosphate, primawuine phosphate, primaauine phosphate, primaqyine phosphate, primaqhine phosphate, primaqjine phosphate, primaqiine phosphate, primaq8ine phosphate, primaq7ine phosphate, primaquune phosphate, primaqujne phosphate, primaqukne phosphate, primaquone phosphate, primaqu9ne phosphate, primaqu8ne phosphate, primaquibe phosphate, primaquime phosphate, primaquije phosphate, primaquihe phosphate, primaquinw phosphate, primaquins phosphate, primaquind phosphate, primaquinr phosphate, primaquin4 phosphate, primaquin3 phosphate, primaquine ohosphate, primaquine lhosphate, primaquine -hosphate, primaquine 0hosphate, primaquine pgosphate, primaquine pbosphate, primaquine pnosphate, primaquine pjosphate, primaquine puosphate, primaquine pyosphate, primaquine phisphate, primaquine phksphate, primaquine phlsphate, primaquine phpsphate, primaquine ph0sphate, primaquine ph9sphate, primaquine phoaphate, primaquine phozphate, primaquine phoxphate, primaquine phodphate, primaquine phoephate, primaquine phowphate, primaquine phosohate, primaquine phoslhate, primaquine phos-hate, primaquine phos0hate, primaquine phospgate, primaquine phospbate, primaquine phospnate, primaquine phospjate, primaquine phospuate, primaquine phospyate, primaquine phosphzte, primaquine phosphste, primaquine phosphwte, primaquine phosphqte, primaquine phosphare, primaquine phosphafe, primaquine phosphage, primaquine phosphaye, primaquine phospha6e, primaquine phospha5e, primaquine phosphatw, primaquine phosphats, primaquine phosphatd, primaquine phosphatr, primaquine phosphat4, primaquine phosphat3, rimaquine phosphate, pimaquine phosphate, prmaquine phosphate, priaquine phosphate, primquine phosphate, primauine phosphate, primaqine phosphate, primaqune phosphate, primaquie phosphate, primaquin phosphate, primaquinephosphate, primaquine hosphate, primaquine posphate, primaquine phsphate, primaquine phophate, primaquine phoshate, primaquine phospate, primaquine phosphte, primaquine phosphae, primaquine phosphat, rpimaquine phosphate, pirmaquine phosphate, prmiaquine phosphate, priamquine phosphate, primqauine phosphate, primauqine phosphate, primaqiune phosphate, primaqunie phosphate, primaquien phosphate, primaquin ephosphate, primaquinep hosphate, primaquine hposphate, primaquine pohsphate, primaquine phsophate, primaquine phopshate, primaquine phoshpate, primaquine phospahte, primaquine phosphtae, primaquine phosphaet, pprimaquine phosphate, prrimaquine phosphate, priimaquine phosphate, primmaquine phosphate, primaaquine phosphate, primaqquine phosphate, primaquuine phosphate, primaquiine phosphate, primaquinne phosphate, primaquinee phosphate, primaquine phosphate, primaquine pphosphate, primaquine phhosphate, primaquine phoosphate, primaquine phossphate, primaquine phospphate, primaquine phosphhate, primaquine phosphaate, primaquine phosphatte, primaquine phosphatee, etc.

© Copyright by 2001-2019. All rights reserved