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Generic Name: Rifapentine (RIF-ah-pen-teen)
Brand Name: Priftin

Priftin is used for:

Treating tuberculosis (TB). It is used along with other medicines.

Priftin is a rifamycin antibiotic. It works by killing or stopping growth of TB organisms.

Do NOT use Priftin if:

  • you are allergic to any ingredient in Priftin or to rifamycins (eg, rifampin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Priftin :

Some medical conditions may interact with Priftin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver disease, abnormal liver function tests, the blood disease porphyria, or pseudomembranous colitis

Some MEDICINES MAY INTERACT with Priftin . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • HIV protease inhibitors (eg, indinavir) because the risk of side effects, including heart, blood, or nerve problems, may be increased
  • Many prescription and nonprescription medicines (eg, used for infections, HIV, heart problems, irregular heartbeat, asthma, inflammation, pain, high blood pressure, diabetes, birth control, blood thinning, high cholesterol, thyroid replacement, seizures, and other conditions) may interact with Priftin

This may not be a complete list of all interactions that may occur. Ask your health care provider if Priftin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Priftin :

Use Priftin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Priftin may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Take Priftin at least 1 hour before or 2 hours after antacids.
  • If you are giving Priftin to a child or you have malnourishment, alcoholism, or diabetes, ask your doctor about taking Priftin with vitamin B6.
  • To clear up your infection completely, continue taking Priftin for the full course of treatment, even if you feel better. Do not miss any doses.
  • It may take several months for Priftin to work. Do not stop using Priftin without checking with your doctor.
  • If you miss a dose of Priftin , take it as soon as possible. If it is less than 72 hours until your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Priftin .

Important safety information:

  • Priftin may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Priftin . Using Priftin alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Priftin may color the urine, stools, sweat, saliva, or tears orange or red. Priftin may permanently stain contact lenses.
  • Priftin is effective only against bacteria. It is not effective for treating viral infections (eg, the common cold).
  • It is important to use Priftin for the full course of treatment. Failure to do so may decrease the effectiveness of Priftin and increase the risk that the bacteria will no longer be sensitive to Priftin and will not be able to be treated by this or certain other antibiotics in the future.
  • Long-term or repeated use of Priftin may cause a second infection. Your doctor may want to change your medicine to treat the second infection. Contact your doctor if signs of a second infection occur.
  • If severe diarrhea, stomach pain/cramps, or bloody stools occur, contact your doctor immediately. This could be a symptom of a serious side effect requiring immediate medical attention. Do not treat diarrhea without consulting your doctor.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Priftin .
  • LAB TESTS, including liver function, complete blood cell counts, platelet counts, and bilirubin levels, may be required to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Priftin is not recommended for use in CHILDREN younger than 12 years of age. Safety and effectiveness in this age group have not been confirmed.
  • Priftin may decrease the effectiveness of your hormonal birth control (eg, birth control pills). To prevent pregnancy, be sure to use an additional form of birth control (eg, condoms) while using Priftin .
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Priftin during pregnancy. It is unknown if this drug is excreted in breast milk. Do not breast-feed while taking Priftin .

Possible side effects of Priftin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Acne; discoloration of body fluids; dizziness; headache; pain; stomach pain; upset stomach.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); appetite loss; dark urine; diarrhea; fever; general body discomfort; joint pain or swelling; nausea; pale stools; sore throat; unusual fatigue; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Symptoms may include headache; heartburn; increased urinary frequency.

Proper storage of Priftin :

Store Priftin below 77 degrees F (25 degrees C) in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Keep Priftin out of the reach of children and away from pets.

General information:

  • If you have any questions about Priftin , please talk with your doctor, pharmacist, or other health care provider.
  • Priftin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Priftin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition
Copyright © 2006 Wolters Kluwer Health, Inc.

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