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Generic Name: Ziconotide (zye-KOE-noe-tide)
Brand Name: Prialt

Treatment with Prialt may cause severe psychiatric and neurological problems. Patients with a history of psychosis should not receive Prialt . You will be monitored often for evidence of thinking problems, hallucinations, or changes in mood or consciousness. If these symptoms occur, Prialt can be stopped without causing withdrawal effects.

Prialt is used for:

Managing severe chronic pain in patients who cannot take medicine by mouth or do not respond well to other treatments.

Prialt is an N-type calcium channel blocker. It works by targeting and blocking N-type calcium channels on nerves that transmit pain signals.

Do NOT use Prialt if:

  • you are allergic to any ingredient in Prialt
  • you have a history of psychosis
  • you have an infection at the injection site or a damaged spinal canal that interferes with circulation of cerebral spinal fluid
  • you have a bleeding disorder

Contact your doctor or health care provider right away if any of these apply to you.

Before using Prialt :

Some medical conditions may interact with Prialt . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, plan to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have or have a history of depression or have ever considered suicide
  • if you have kidney problems

Some MEDICINES MAY INTERACT with Prialt . However, no specific interactions with Prialt are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Prialt may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Prialt :

Use Prialt as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Prialt is usually administered as an injection at your doctor"s office, hospital, or clinic. Ask your doctor if you have any questions about Prialt .
  • If you miss a dose of Prialt , contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Prialt .

Important safety information:

  • Prialt may cause drowsiness, dizziness, or decreased alertness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Prialt . Using Prialt alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Prialt . Prialt will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
  • Prialt is not an opiate and cannot prevent or reduce symptoms of opiate withdrawal. Talk with your doctor about withdrawal from opiate treatment.
  • LAB TESTS, including kidney function tests, may be performed to monitor your progress. Be sure to keep all doctor and lab appointments.
  • Prialt is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using Prialt during pregnancy. It is unknown if Prialt is excreted in breast milk. Do not breast-feed while using Prialt .

Possible side effects of Prialt :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal walking; back pain; bad taste in mouth; burning, aching, tingling sensation on the skin; constipation; diarrhea; dizziness; dry skin; feeling of a whirling motion; incoordination; increased cough; loss of appetite; muscle tension; pain; pain at insertion site; rapid, jerky eye movements; ringing in the ears; runny nose; skin irritation; sleepiness; sore throat; stomach pain; sweating; vision changes.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal thinking; anxiety; change in mental state (eg, lack of energy, confusion, disorientation); change in mood or perception (eg, hallucinations; unusual sensations in the mouth; paranoia; hostility; delirium; manic reactions; psychosis); chest pain; dark urine; depression; fainting; fever; flu-like symptoms; headache; inability to empty the bladder; memory problems or memory loss; muscle cramps; muscle or joint pain; nausea; nervousness; pounding in the chest; seizures; speech problems; stiff neck; stupor; suicidal thoughts or behaviors; unresponsiveness; urination problems; vomiting; weakness.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Symptoms may include confusion; dizziness; drowsiness; garbled speech; loss of coordination; muscle twitching; nausea; rapid eye movement; stupor; unresponsiveness.

Proper storage of Prialt :

Store Prialt as directed on the prescription label. Keep Prialt out of the reach of children and away from pets.

General information:

  • If you have any questions about Prialt , please talk with your doctor, pharmacist, or other health care provider.
  • Prialt is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Prialt . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition
Copyright © 2006 Wolters Kluwer Health, Inc.

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Typical mistypes for Prialt
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