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Generic Name: Darunavir (dar-UE-na-vir)
Brand Name: Prezista

Prezista is used for:

Treating HIV infection in certain patients along with other antiretroviral medicines. Prezista must always be taken along with another medicine called ritonavir.

Prezista is an HIV protease inhibitor. It works by blocking the growth activity of an enzyme (HIV protease) that the HIV virus needs to reproduce in the body.

Do NOT use Prezista if:

  • you are allergic to any ingredient in Prezista
  • you are taking certain H1 antagonists (eg, astemizole, terfenadine), certain benzodiazepines (eg, midazolam, triazolam), carbamazepine, certain HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin), cisapride, an ergot derivative (eg, ergotamine, ergonovine), phenytoin, pimozide, phenobarbital, rifampin, or St. John"s wort

Contact your doctor or health care provider right away if any of these apply to you.

Before using Prezista :

Some medical conditions may interact with Prezista . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any other sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glyburide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide
  • if you have a history of hepatitis or other liver problems, high blood cholesterol or triglycerides, infection, bleeding problems (eg hemophilia), diabetes, or a family history of diabetes

Some MEDICINES MAY INTERACT with Prezista . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Astemizole, cisapride, ergot derivatives (eg, ergotamine, ergonovine), pimozide, or terfenadine because the risk of severe blood vessel problems or serious and possibly life-threatening irregular heartbeat may be increased
  • Certain HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin) because the risk of severe muscle and kidney problems may be increased
  • Certain benzodiazepines (eg, midazolam, triazolam) because the risk of severe or prolonged nervous system depression or breathing problems may be increased
  • Carbamazepine, phenobarbital, phenytoin, rifampin, St. John"s wort because they may decrease Prezista "s effectiveness
  • Many other prescription and nonprescription medicines (eg, used for asthma, birth control, blood thinning, heart problems, heartburn, high blood pressure, high cholesterol, HIV infection, immune system suppression, impotence, infections, irregular heartbeat, mental or mood problems, migraine headaches, pain seizures), and herbs found in multivitamin products, herbal teas, and dietary supplements may interact with Prezista and increase the risk of side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Prezista may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Prezista :

Use Prezista as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Prezista . Talk to your pharmacist if you have questions about this information.
  • Take Prezista with food. Ritonavir should also be taken at the same time as Prezista .
  • Swallow Prezista whole with a drink such as water or milk. Do not break, crush, or chew before swallowing.
  • Taking this medicine at the same time each day will help you remember to take it.
  • Take Prezista on a regular schedule to get the most benefit from it.
  • Continue to take Prezista even if you feel well. Do not miss any doses.
  • If you miss a dose of Prezista by less than 6 hours, take it as soon as possible and go back to your regular dosing schedule. If you miss a dose of Prezista by more than 6 hours, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Prezista .

Important safety information:

  • Keep a list of all the medicines that you take. Make a new list each time a medicine is added or stopped. Find out about medicines that should not be taken while you are using Prezista . Be sure that each of your health care providers knows all the medicines that you are taking.
  • Changes in body fat (eg, an increased amount of fat in the upper back, neck, breast, and trunk, and loss of fat from the legs, arms, and face) may occur in some patients taking Prezista . The cause and long-term effects of these changes are unknown. Discuss any concerns with your doctor. Do not stop taking Prezista or change your dose without talking with your doctor.
  • Prezista may improve immune system function. This may reveal hidden infections in some patients. Tell your doctor right away if you notice symptoms of infection (eg, fever, sore throat, weakness, cough, shortness of breath) after you start Prezista .
  • Prezista is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor. The long-term effects of taking Prezista are unknown.
  • Prezista does not stop the spread of HIV to others through blood or sexual contact. Use barrier methods of birth control (eg, condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors.
  • Do NOT take more than the recommended dose, change the dose, or stop taking Prezista or ritonavir without checking with your doctor.
  • When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking Prezista , even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat.
  • Hormonal birth control (eg, birth control pills) may not work as well while you are using Prezista . To prevent pregnancy, use an extra form of birth control (eg, condoms).
  • Hemophilia patients - Report all bleeding episodes to your doctor.
  • Prezista may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
  • Diabetes patients - Prezista may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Prezista may increase triglyceride and lipid levels. The long-term chance of complications from this, such as heart attack and stroke, are not known at this time.
  • Lab tests, including liver function, blood cholesterol or triglyceride levels, blood glucose levels, blood electrolyte levels, and complete blood cell counts, may be performed while you use Prezista . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Prezista with caution in the ELDERLY; they may be more sensitive to its effects.
  • Prezista should be used with extreme caution in CHILDREN; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY AND BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Prezista while you are pregnant. It is not known if Prezista is found in breast milk. Do not breast-feed while taking Prezista . Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or Prezista to the baby.

Possible side effects of Prezista :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; headache; nausea; nose and throat irritation.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in the amount of urine produced; chest pain; confusion; fast heartbeat; fever, chills, or persistent sore throat; rapid breathing; red, swollen, or blistered skin; severe headache or dizziness; unusual bleeding or bruising; unusual drowsiness; unusual swelling of the arms or legs; unusual thirst.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. If you have any questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately.

Proper storage of Prezista :

Store Prezista at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store Prezista in the bathroom. Keep Prezista out of the reach of children and away from pets.

General information:

  • If you have any questions about Prezista , please talk with your doctor, pharmacist, or other health care provider.
  • Prezista is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Prezista . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition
Copyright © 2006 Wolters Kluwer Health, Inc.

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