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PREVACID NapraPAC 375, PREVACID NapraPAC 500, |PREVACID NapraPAC 375

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PREVACID NapraPAC 375

Generic Name: lansoprazole and naproxen (lan SOE pra zole and na PROX en)
Brand Names: PREVACID NapraPAC 375, PREVACID NapraPAC 500

What is lansoprazole and naproxen?

Naproxen is in a group of drugs called NSAIDs (nonsteroidal anti-inflammatory drugs). It works by reducing substances in the body that cause inflammation, pain, and fever.

Lansoprazole is in a group of drugs called proton pump inhibitors. It decreases the amount of acid produced in the stomach.

The combination of lansoprazole and naproxen is used to treat symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The lansoprazole in this medication helps reduce the risk of stomach ulcers in people who may be at risk for them while receiving treatment with an NSAID.

Lansoprazole and naproxen may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about lansoprazole and naproxen?

The naproxen in this medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use naproxen. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

Naproxen can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking naproxen. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. Do not use any other over-the-counter pain or arthritis medication without first asking your doctor or pharmacist. Naproxen is contained in many medicines available over the counter. Read the label of any other medicine you are using to see if it contains naproxen.

What should I discuss with my healthcare provider before taking lansoprazole and naproxen?

Do not use this medication if you are allergic to lansoprazole (Prevacid) or naproxen (Aleve, Anaprox, Naprosyn, and others).

Taking an NSAID can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use the NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Before using this medication, tell your doctor if you are allergic to any drugs, or if you have:

liver or kidney disease;
heart disease, high blood pressure, or a history of stroke, heart attack, or congestive heart failure;
a bleeding or blood clotting disorder, such as hemophilia; or
a history of allergic reaction to asprin, especially asprin triad syndrome.

You may not be able to take lansoprazole and naproxen, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Naproxen can pass into breast milk and may harm a nursing baby. It is not known whether lansoprazole passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take lansoprazole and naproxen?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Each package of this medication contains pills for 7 days of treatment (one lansoprazole capsule and two naproxen tablets per day). Follow your doctor"s instructions about when to take each pill.

In most cases, you will take one lansoprazole (Prevacid) capsule and one naproxen (Naprosyn) tablet each morning before eating. The second naproxen tablet is then taken 12 hours later, without lansoprazole.

Take this medication with a full glass of water. Do not crush, chew, break, or open the lansoprazole capsule. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. You may also need eye exams if you have any changes in your vision. Do not miss any scheduled visits to your doctor.

Store this medicine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a lansoprazole and naproxen overdose may include nausea, vomiting, stomach pain, dizziness, drowsiness, confusion, trouble breathing, and urinating less than usual or not at all.

What should I avoid while taking lansoprazole and naproxen?

Do not use any other over-the-counter pain or arthritis medication without first asking your doctor or pharmacist. Naproxen is contained in many medicines available over the counter. If you take certain products together you may accidentally take too much naproxen. Read the label of any other medicine you are using to see if it contains naproxen. If you drink more than three alcoholic beverages per day, do not take this medication without your doctor"s advice. Alcohol and naproxen together may increase the risk of bleeding in the stomach.

Lansoprazole and naproxen side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
sudden numbness or weakness, especially on one side of the body;
sudden headache, confusion, problems with vision, speech, or balance;
swelling, rapid weight gain, feeling short of breath, even with mild exertion;
black, bloody, or tarry stools;
coughing up blood or vomit that looks like coffee grounds;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
pale skin, easy bruising, weakness.

Continue using this medication and talk with your doctor if you have any of these less serious side effects:

stomach pain, constipation, nausea, heartburn;
headache, dizziness or drowsiness; or
ringing in your ears.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect lansoprazole and naproxen?

Before taking this medication, tell your doctor if you are using any of the following drugs:

a blood thinner such as warfarin (Coumadin);
diabetes medications you take by mouth;
phenytoin (Dilantin);
probenecid (Benemid);
lithium (Eskalith, Lithobid, others);
steroids (prednisone and others);
aspirin or other NSAIDs such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin (Indocin), ketoprofen (Orudis), and others;
a diuretic (water pill) such as bumetanide (Bumex), chlorothiazide (Diuril), ethacrynic acid (Edecrin), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Lopressor, Vasoretic, Zestoretic), chlorthalidone (Hygroton, Thalitone), indapamide (Lozol), metolazone (Mykrox, Zaroxolyn), or torsemide (Demadex);
an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik); or
a beta-blocker such as acebutolol (Sectral), atenolol (Tenormin), betaxolol (Kerlone), bisoprolol (Zebeta), carvedilol (Coreg), esmolol (Brevibloc), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), penbutolol (Levatol), pindolol (Visken), propranolol (Inderal, InnoPran), sotalol (Betapace), or timolol (Blocadren).

If you are using any of these drugs, you may not be able to use lansoprazole and naproxen, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect lansoprazole and naproxen. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist has information about lansoprazole and naproxen written for health professionals that you may read.

What does my medication look like?

Lansoprazole and naproxen is available with a prescription under the brand name Prevacid NapraPAC. Prevacid NapraPAC is a combination package containing Naprosyn (naproxen) tablets and Prevacid (lansoprazole) capsules. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Prevacid NapraPAC 375-pink, oval Naprosyn tablets and pink and green hard gelatin 15 mg Prevacid capsules
Prevacid NapraPAC 500 mg-yellow, capsule-shaped Naprosyn tablets and pink and green hard gelatin 15 mg Prevacid capsules

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 2.02. Revision Date: 11/1/06 3:29:43 PM.

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