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Some commonly used brand names are:
In the U.S.—
Other commonly used names are prostaglandin E 2 or PGE 2 .
Dinoprostone (dye-noe-PROST-one) works by causing the cervix to thin and dilate (open) and the uterus to contract (cramp) the way it does during labor.
Dinoprostone may also be used for other purposes as determined by your doctor.
Dinoprostone is to be administered only by or under the immediate care of your doctor. It is available in the following dosage forms:
Before Receiving This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For dinoprostone, the following should be considered:
Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to dinoprostone, misoprostol, oxytocin or other medicines that stimulate the uterus to contract.
Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving dinoprostone, it is especially important that your doctor knows if you are using any other vaginal prescription or nonprescription (over-the-counter [OTC]) medicine.
Other medical problems—The presence of other medical problems may affect the use of dinoprostone. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
After dinoprostone is given, you will need to lie down for 10 minutes to 2 hours so that the medicine can be absorbed. The length of time you must remain lying down will depend on what form of the medicine you are using.
Dosing—The dose of dinoprostone will be different for different patients. The following information includes only the average doses for dinoprostone. Your doctor will give you the dose of this medicine and follow your care in a hospital or other health care setting.
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Tell the health care professional immediately if any of the following side effects occur:
Less common or rare
Fast or slow heartbeat; hives; increased pain of the uterus; pale, cool, blotchy skin on arms or legs; pressing or painful feeling in chest; shortness of breath; swelling of face, inside the nose, and eyelids; tightness in chest; trouble in breathing; weak or absent pulse in arms or legs; wheezing
Other side effects may occur that usually do not need medical attention. These side effects usually go away after the medicine is stopped. However, let the health care professional know if any of the following side effects continue or are bothersome:
Abdominal or stomach cramps; diarrhea; fever; nausea; vomiting
Less common or rare
Chills or shivering; constipation; flushing; headache; swelling of the genital area (vulva); tender or mildly bloated abdomen or stomach
This procedure may still result in some effects, which occur after the procedure is completed, that need medical attention. Check with your doctor if any of the following side effects occur:
Chills or shivering (continuing); fever (continuing); foul-smelling vaginal discharge; pain in lower abdomen; unusual increase in bleeding of the uterus
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your health care professional.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, dinoprostone is used in certain patients with the following medical condition:
Other than the above information, there is no additional information relating to proper use, precautions, or side effects for this use.
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