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|Poractant Alfa |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Poractant AlfaPronouncation: (pore-ACK-tant AL-fuh)Class: Lung surfactant Trade Names: Mechanism of ActionPharmacologyExtract of natural porcine lung surfactant that restores lung surfactant in premature infants with lung surfactant deficiency causing respiratory distress syndrome (RDS). Indications and UsageTreatment of RDS in premature infants. Unlabeled UsesSevere meconium aspiration syndrome in term infants; respiratory failure caused by group B streptococcal infection in neonates. ContraindicationsStandard considerations. Dosage and AdministrationNewborn infantsIntratracheal Initial dose: 2.5 mL/kg birth weight. Repeat doses: Up to 2 repeat doses of 1.25 mL/kg birth weight may be administered q 12 hr for total of 3 doses. Max dose (initial and up to 2 repeat doses): 5 mL/kg. General Advice
Storage/StabilityStore vials in refrigerator (36° to 46°F). Unopened vials may be warmed to room temperature for up to 24 hr prior to use. Unopened vials that have been warmed to room temperature may be returned to refrigerated storage within 24 hr for future use. Do not warm and return to refrigerator more than once. Protect from light. Vials are for single use only. Discard any unused portion of poractant alfa. Do not save unused portions for future use. Drug InteractionsNone well documented. Laboratory Test InteractionsNone well documented. Adverse ReactionsCardiovascularTransient bradycardia; hypotension. MiscellaneousTransient endotracheal tube blockage; oxygen desaturation. Precautions
DosingDuring administration of poractant alfa, monitor the infant for bradycardia, hypotension, endotracheal tube blockage (reflux of poractant alfa into endotracheal tube), or oxygen desaturation. If any of these events occur, interrupt administration and take appropriate measures to alleviate the condition. After the patient is stable, dosing may proceed with appropriate monitoring. PreadministrationEnsure that efforts are made to correct acidosis, hypotension, anemia, hypoglycemia, and hypothermia before administering poractant alfa. Patient Information
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