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|Polythiazide/Prazosin

Polythiazide/Prazosin

Polythiazide/Prazosin is used for:

Treating high blood pressure. It may also be used for other conditions as determined by your doctor.

Polythiazide/Prazosin is an alpha-blocker and thiazide diuretic combination. It works by widening blood vessels and helping the kidneys eliminate extra fluid from your body, which helps lower blood pressure.

Do NOT use Polythiazide/Prazosin if:

• you are allergic to any ingredient in Polythiazide/Prazosin or to any other sulfonamide medicine (eg sulfamethoxazole, glyburide, acetazolamide)
• you are unable to urinate
• you are taking dofetilide, ketanserin, a phosphodiesterase type 5 inhibitor (eg, sildenafil, tadalafil, vardenafil), or modafinil

Contact your doctor or health care provider right away if any of these apply to you.

Before using Polythiazide/Prazosin :

Some medical conditions may interact with Polythiazide/Prazosin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have gout, kidney or liver problems, lupus, diabetes, asthma, parathyroid problems, high blood cholesterol or lipid levels, chest pain, heart problems, narcolepsy, or low blood pressure
• if you have low blood sodium, chloride, potassium, or magnesium levels; or high blood calcium levels
• if you have recently had nerve surgery

Some MEDICINES MAY INTERACT with Polythiazide/Prazosin . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Nonsteroidal anti-inflammatory medicines (NSAIDs) (eg, indomethacin) because they decrease the effectiveness of Polythiazide/Prazosin
• Barbiturates (eg, phenobarbital), corticosteroids (eg, prednisone), corticotropin (ACTH), medicines for high blood pressure, narcotic pain medicines (eg, codeine, morphine, fentanyl), or verapamil because side effects of Polythiazide/Prazosin may be increased
• Diazoxide or nondepolarizing muscle relaxants (eg, tubocurarine) because side effects may be increased by Polythiazide/Prazosin
• Lithium because risk of toxicity may be increased by Polythiazide/Prazosin
• Beta-blockers (eg, propranolol), bupivacaine, digoxin, dofetilide, ketanserin, nifedipine, or phosphodiesterase type 5 inhibitors (eg, sildenafil, tadalafil , vardenafil) because side effects of these medicines may be increased
• Diabetes medicines (eg, glipizide, metformin), insulin, or modafinil because their effectiveness may be decreased by Polythiazide/Prazosin

This may not be a complete list of all interactions that may occur. Ask your health care provider if Polythiazide/Prazosin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Polythiazide/Prazosin :

Use Polythiazide/Prazosin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Polythiazide/Prazosin may be taken with or without food.
• When you first start taking Polythiazide/Prazosin , it may cause an increase in urine or in frequency of urination. To prevent this from affecting sleep, try not to take any dose later than 6 pm.
• Continue to use Polythiazide/Prazosin even if you feel well. Do not miss any doses.
• Taking Polythiazide/Prazosin at the same time each day will help you remember to take it.
• Take Polythiazide/Prazosin regularly to receive the most benefit from it.
• If you miss a dose of Polythiazide/Prazosin , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Polythiazide/Prazosin .

Important safety information:

• Polythiazide/Prazosin may cause dizziness, drowsiness, lightheadedness, fainting, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Polythiazide/Prazosin . Using Polythiazide/Prazosin alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Polythiazide/Prazosin may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.
• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Polythiazide/Prazosin .
• Polythiazide/Prazosin may cause high blood sugar (eg, thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor). If these symptoms occur, tell your doctor immediately.
• Your doctor may have also prescribed a potassium supplement for you. If so, follow the dosing carefully. Do not start taking additional potassium on your own or change your diet to include more potassium without first checking with your doctor.
• Polythiazide/Prazosin may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Polythiazide/Prazosin . Use a sunscreen or protective clothing if you must be outside for a prolonged period.
• Patients being treated for high blood pressure often feel tired or run down for a few weeks after beginning therapy. Continue taking your medication even though you may not feel quite "normal." Contact your doctor or pharmacist about any new symptoms.
• LAB TESTS, including kidney function, blood pressure, and blood electrolyte levels, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
• Use Polythiazide/Prazosin with caution in the ELDERLY because they may be more sensitive to its effects.
• Polythiazide/Prazosin is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Polythiazide/Prazosin during pregnancy. Polythiazide/Prazosin is excreted in breast milk. Do not breast-feed while taking Polythiazide/Prazosin .

Possible side effects of Polythiazide/Prazosin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; dry mouth; flushing; headache; lightheadedness, especially when sitting up or standing; numbness or tingling of skin.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; changes in sexual function; confusion; decrease in amount of urine; drowsiness; fainting; gout; muscle pain or cramps; rapid or irregular heartbeat; red, swollen, blistered, or peeling skin; restlessness; seizures; shortness of breath; stomach pain; unusual thirst; unusual tiredness or weakness; unusually dry mouth; vomiting.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include dry mouth; excessive urination followed by a decrease in amount of urine; muscle cramps; severe lightheadedness, especially upon standing; weak or irregular heartbeat.

Store Polythiazide/Prazosin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Polythiazide/Prazosin out of the reach of children and away from pets.

General information:

• If you have any questions about Polythiazide/Prazosin , please talk with your doctor, pharmacist, or other health care provider.
• Polythiazide/Prazosin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Polythiazide/Prazosin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.