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Pletal, |Pletal Pletal

Pletal

Generic Name: cilostazol (sil OS tah zol)
Brand Names: Pletal

What is cilostazol?

Cilostazol widens arteries that supply blood to the legs. Cilostazol also improves circulation by keeping platelets in the blood from sticking together and clotting.

Cilostazol is used to treat the symptoms of intermittent claudication. This condition causes reduced blood flow to the legs, leading to pain while walking. Cilostazol improves your ability to walk longer distances without pain.

Cilostazol may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about cilostazol?

Your symptoms may not improve for at least 2 to 4 weeks after you start taking cilostazol. You may need to take this medicine for up to 12 weeks before you notice improvement. Tell your doctor if your symptoms do not improve within that time.

Grapefruit and grapefruit juice may interact with cilostazol. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

What should I discuss with my healthcare provider before taking cilostazol?

Before using cilostazol, tell your doctor if you have:

• heart disease; or

• liver disease.

If you have any of these conditions, you may not be able to use cilostazol, or you may need a dosage adjustment or special tests during treatment.

How should I take cilostazol?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.

Your symptoms may not improve for at least 2 to 4 weeks after you start taking cilostazol. You may need to take this medicine for up to 12 weeks before you notice improvement. Tell your doctor if your symptoms do not improve within that time.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Symptoms of a cilostazol overdose may include a severe headache, diarrhea, feeling light-headed, fainting, and fast or uneven heartbeats.

What should I avoid while taking cilostazol?

Grapefruit and grapefruit juice may interact with cilostazol. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

Cilostazol side effects

• severe headache;

• bloody urine, painful urination;

• fever, chills, body aches, flu symptoms;

• chest pain;

• feeling short of breath, even with mild exertion; or

• swelling of your ankles or feet.

Other less serious side effects are more likely to occur, such as:

• fast or pounding heartbeats;

• diarrhea, vomiting;

• weakness, dizziness;

• leg cramps;

• numbness or tingling;

• joint pain; or

• cough, runny or stuffy nose.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect cilostazol?

Before taking cilostazol, tell your doctor if you are using any of the following drugs:

• clopidogrel (Plavix);

• omeprazole (Prilosec, Zegerid) or esomeprazole (Nexium);

• erythromycin (E.E.S., Ery-Tab, E-Mycin, Erythrocin) or clarithromycin (Biaxin);

• ketoconazole (Nizoral), fluconazole (Diflucan), or itraconazole (Sporanox);

• diltiazem (Cardizem, Tiazac); or

• fluvoxamine (Luvox), fluoxetine (Prozac), sertraline (Zoloft), or nefazodone (Serzone).

If you are using any of these drugs, you may not be able to use cilostazol, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect cilostazol. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist has more information about cilostazol written for health professionals that you may read.

What does my medication look like?

Cilostazol is available with a prescription under the brand name Pletal. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Pletal 50 mg-white, triangular tablets

• Pletal 100 mg-white, round tablets

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.