Piperacillin

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|Piperacillin

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Piperacillin


Generic Name: Piperacillin (pi-PER-a-sil-in)
Brand Name: Generic only. No brands available.

Piperacillin is used for:

Treating serious bacterial infections. It may also be used to prevent infections during surgery.

Piperacillin is an antibacterial agent. It works by blocking the bacteria"s cell wall growth, which kills the bacteria.

Do NOT use Piperacillin if:

  • you are allergic to any ingredient in Piperacillin
  • you have a history of allergic reaction to any penicillin (eg, amoxicillin), cephalosporin (eg, cephalexin), or beta-lactam antibiotic (eg, imipenem)
  • you are taking a tetracycline antibiotic (eg, doxycycline)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Piperacillin :

Some medical conditions may interact with Piperacillin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have cystic fibrosis, bowel inflammation, bleeding problems, congestive heart failure, or kidney problems
  • if you are on dialysis, or if you have a history of severe diarrhea or bowel problems due to an antibiotic
  • if you are on a salt-restricted diet or have low blood potassium levels

Some MEDICINES MAY INTERACT with Piperacillin . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Tetracyclines because they may decrease the effectiveness of this medicine
  • Aminoglycosides (eg, tobramycin) or oral contraceptives (birth control pills) because their effectiveness may be decreased by Piperacillin
  • Heparin, methotrexate, or nondepolarizing muscle relaxants (eg, vecuronium) because their actions and side effects may be increased by Piperacillin
  • Anticoagulants (eg, warfarin) because effectiveness may be decreased or the risk of side effects may be increased by Piperacillin
  • Chemotherapy or diuretics (eg, furosemide, hydrochlorothiazide) because the risk of side effects, such as low blood potassium levels, may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Piperacillin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Piperacillin :

Use Piperacillin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Piperacillin is usually administered as an injection at your doctor"s office, hospital, or clinic. If you are using Piperacillin at home, carefully follow the injection procedures taught to you by your health care provider.
  • If Piperacillin contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of Piperacillin , use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use this medicine.

Important safety information:

  • Piperacillin may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Piperacillin . Using Piperacillin alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Piperacillin may decrease the effectiveness of your birth control pill. To prevent pregnancy, be sure to use an additional form of birth control (eg, condoms) while using Piperacillin .
  • Piperacillin may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
  • If severe diarrhea, stomach pain/cramps, or bloody stools occur, contact your doctor immediately. This could be a symptom of a serious side effect requiring immediate medical attention. Do not treat diarrhea without consulting your doctor.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Piperacillin .
  • Piperacillin is effective only against bacteria. It is not effective for treating viral infections (eg, the common cold).
  • It is important to use Piperacillin for the full course of treatment. Failure to do so may decrease the effectiveness of Piperacillin and increase the risk that the bacteria will no longer be sensitive to Piperacillin and will not be able to be treated by this or certain other antibiotics in the future.
  • Long-term or repeated use of Piperacillin may cause a second infection. Your doctor may want to change your medicine to treat the second infection. Contact your doctor if signs of a second infection occur.
  • Diabetes patients - Piperacillin may cause incorrect test results with some urine glucose tests. Check with your doctor before you adjust the dose of your diabetes medicine or change your diet.
  • Piperacillin may affect certain lab test results. Make sure your doctor and lab personnel know you are using Piperacillin .
  • LAB TESTS, including blood electrolyte levels, kidney or liver function, and complete blood cell counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Piperacillin with caution in the ELDERLY because they may be more sensitive to its effects.
  • Use Piperacillin with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Piperacillin , discuss with your doctor the benefits and risks of using Piperacillin during pregnancy. Piperacillin is excreted in breast milk. If you are or will be breast-feeding while you are using Piperacillin , check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Piperacillin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; headache; loose stools; nausea; pain, swelling, or redness at the injection site; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; calf pain or tenderness; decreased urination; fever, chills, or sore throat; inflammation at injection site; prolonged muscle relaxation; red, swollen, or blistered skin; seizures; severe diarrhea, vomiting, or stomach pain; unusual bruising or bleeding; unusual tiredness or weakness; vaginal irritation or discharge; vein inflammation or tenderness; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include excitability; seizures.

Proper storage of Piperacillin :

Piperacillin is usually handled and stored by a health care provider. If you are using Piperacillin at home, store Piperacillin as directed by your pharmacist or health care provider.

General information:

  • If you have any questions about Piperacillin , please talk with your doctor, pharmacist, or other health care provider.
  • Piperacillin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Piperacillin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition 06.4.1.002
Copyright © 2006 Wolters Kluwer Health, Inc.




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