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|Phentermine HCl |
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Storage/StabilityStore at controlled room temperature (59° to 86°F). Drug InteractionsGuanethidineMay decrease hypotensive effect of guanethidine. MAOIs (eg, phenelzine); furazolidoneMay cause hypertensive crisis and intracranial hemorrhage. Selective serotonin reuptake inhibitors (eg, fluoxetine)Sympathomimetic effects of phentermine and risk of “serotonin syndrome” may be increased. Laboratory Test InteractionsNone well documented. Adverse ReactionsCardiovascularRegurgitant cardiac valvular disease; palpitation; tachycardia; hypertension. CNSOverstimulation; restlessness; dizziness; insomnia; euphoria; dysphoria; tremor; headache; psychotic episodes. DermatologicAllergic urticaria. GIDry mouth; unpleasant taste; diarrhea; constipation. GenitourinaryImpotence; changes in libido. RespiratoryPrimary pulmonary hypertension. PrecautionsPregnancyCategory C . LactationUndetermined. Children8 mg doseSafety and efficacy not established in children less than 12 yr. 16 mg doseSafety and efficacy not established in children 16 yr or less. Special Risk PatientsUse with caution in patients with glaucoma, hypertension, and diabetes mellitus. Drug dependencePsychological and physical dependence may occur with continued use; this class of drugs has been extensively abused. ToleranceTolerance to the anorectic effect usually develops within a few weeks. Primary pulmonary hypertensionHas been reported with concurrent use of phentermine and fenfluramine or dexfenfluramine. Valvular heart diseaseSerious regurgitant cardiac valvular disease has been reported with concurrent use of phentermine and fenfluramine or dexfenfluramine. OverdosageSymptomsRestlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, panic states, fatigue, depression, arrhythmias, hypertension, hypotension, circulatory collapse, nausea, vomiting, diarrhea, abdominal cramps, convulsions, coma, death. Patient Information
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