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Generic Name: Dipyridamole Tablets (dye-peer-ID-a-mole)
Brand Name: Persantine

Persantine is used for:

Preventing blood clots after heart valve surgery. It is used in combination with anticoagulants (eg, warfarin). It also may be used for other conditions as determined by your doctor.

Persantine is a platelet inhibitor. How it works is not fully understood. It is thought to work by increasing the levels of a body chemical (adenosine), which widens blood vessels and decreases platelet activity.

Do NOT use Persantine if:

  • you are allergic to any ingredient in Persantine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Persantine :

Some medical conditions may interact with Persantine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have severe heart disease, chest pain, low blood pressure, or liver problems, or you have recently had a heart attack

Some MEDICINES MAY INTERACT with Persantine . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Adenosine because the risk of its side effects, including low blood pressure and irregular heartbeat, may be increased by Persantine
  • Anticholinesterases (eg, neostigmine) because their effectiveness may be decreased by Persantine

This may not be a complete list of all interactions that may occur. Ask your health care provider if Persantine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Persantine :

Use Persantine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Persantine by mouth on an empty stomach at least 1 hour before or 2 hours after eating. It may be taken with food if it upsets your stomach.
  • If you miss a dose of Persantine , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Persantine .

Important safety information:

  • Persantine may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Persantine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Persantine may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Tell your doctor or dentist that you take Persantine before you receive any medical or dental care, emergency care, or surgery.
  • Use Persantine with caution in the ELDERLY; they may be more sensitive to its effects.
  • Persantine should not be used in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Persantine while you are pregnant. Persantine is found in breast milk. If you are or will be breast-feeding while you use Persantine , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Persantine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; flushing; headache; itching; stomach pain; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fast heartbeat; hepatitis; pounding in the chest; swelling of throat.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Symptoms may include depression; diarrhea; low blood pressure; vomiting.

Proper storage of Persantine :

Store Persantine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Persantine out of the reach of children and away from pets.

General information:

  • If you have any questions about Persantine , please talk with your doctor, pharmacist, or other health care provider.
  • Persantine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Persantine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition
Copyright © 2006 Wolters Kluwer Health, Inc.

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